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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-85635770-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=85635770&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 85635770,
"ref": "C",
"alt": "A",
"effect": "intron_variant",
"transcript": "NM_014615.5",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.226+1638C>A",
"hgvs_p": null,
"transcript": "NM_014615.5",
"protein_id": "NP_055430.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1217,
"cds_start": null,
"cds_end": null,
"cds_length": 3654,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000253458.12",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_014615.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.226+1638C>A",
"hgvs_p": null,
"transcript": "ENST00000253458.12",
"protein_id": "ENSP00000253458.6",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1217,
"cds_start": null,
"cds_end": null,
"cds_length": 3654,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_014615.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000253458.12"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.8-12782C>A",
"hgvs_p": null,
"transcript": "ENST00000393243.5",
"protein_id": "ENSP00000376934.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1144,
"cds_start": null,
"cds_end": null,
"cds_length": 3435,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000393243.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.-86-12782C>A",
"hgvs_p": null,
"transcript": "ENST00000405402.6",
"protein_id": "ENSP00000384839.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1113,
"cds_start": null,
"cds_end": null,
"cds_length": 3342,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000405402.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.226+1638C>A",
"hgvs_p": null,
"transcript": "ENST00000912462.1",
"protein_id": "ENSP00000582521.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1215,
"cds_start": null,
"cds_end": null,
"cds_length": 3648,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912462.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.226+1638C>A",
"hgvs_p": null,
"transcript": "ENST00000880625.1",
"protein_id": "ENSP00000550684.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1203,
"cds_start": null,
"cds_end": null,
"cds_length": 3612,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000880625.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.8-12782C>A",
"hgvs_p": null,
"transcript": "NM_001278184.3",
"protein_id": "NP_001265113.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1144,
"cds_start": null,
"cds_end": null,
"cds_length": 3435,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001278184.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.8-12782C>A",
"hgvs_p": null,
"transcript": "ENST00000880624.1",
"protein_id": "ENSP00000550683.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1130,
"cds_start": null,
"cds_end": null,
"cds_length": 3393,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000880624.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.-86-12782C>A",
"hgvs_p": null,
"transcript": "NM_001134473.3",
"protein_id": "NP_001127945.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1113,
"cds_start": null,
"cds_end": null,
"cds_length": 3342,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001134473.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.226+1638C>A",
"hgvs_p": null,
"transcript": "ENST00000880623.1",
"protein_id": "ENSP00000550682.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1055,
"cds_start": null,
"cds_end": null,
"cds_length": 3168,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000880623.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.-86-12782C>A",
"hgvs_p": null,
"transcript": "ENST00000411612.5",
"protein_id": "ENSP00000409006.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 209,
"cds_start": null,
"cds_end": null,
"cds_length": 632,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000411612.5"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.38-12782C>A",
"hgvs_p": null,
"transcript": "ENST00000635906.1",
"protein_id": "ENSP00000490289.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 101,
"cds_start": null,
"cds_end": null,
"cds_length": 306,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000635906.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.2350+1638C>A",
"hgvs_p": null,
"transcript": "XM_005255859.6",
"protein_id": "XP_005255916.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1925,
"cds_start": null,
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"cds_length": 5778,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005255859.6"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.2350+1638C>A",
"hgvs_p": null,
"transcript": "XM_005255860.4",
"protein_id": "XP_005255917.3",
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_005255860.4"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.2132-12782C>A",
"hgvs_p": null,
"transcript": "XM_005255861.6",
"protein_id": "XP_005255918.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1852,
"cds_start": null,
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"cds_length": 5559,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005255861.6"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.334+1638C>A",
"hgvs_p": null,
"transcript": "XM_011522965.4",
"protein_id": "XP_011521267.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_011522965.4"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.310+1638C>A",
"hgvs_p": null,
"transcript": "XM_047433818.1",
"protein_id": "XP_047289774.1",
"transcript_support_level": null,
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"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_047433818.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.289+1638C>A",
"hgvs_p": null,
"transcript": "XM_047433819.1",
"protein_id": "XP_047289775.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"feature": "XM_047433819.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 2,
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"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.262+1638C>A",
"hgvs_p": null,
"transcript": "XM_005255863.5",
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.256+1638C>A",
"hgvs_p": null,
"transcript": "XM_005255864.5",
"protein_id": "XP_005255921.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 2,
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"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.232+1638C>A",
"hgvs_p": null,
"transcript": "XM_047433820.1",
"protein_id": "XP_047289776.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047433820.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "GSE1",
"gene_hgnc_id": 28979,
"hgvs_c": "c.217+1638C>A",
"hgvs_p": null,
"transcript": "XM_011522966.4",
"protein_id": "XP_011521268.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1214,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011522966.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
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