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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-89380011-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=89380011&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 89380011,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000711617.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ANKRD11",
"gene_hgnc_id": 21316,
"hgvs_c": "c.-60+38273C>G",
"hgvs_p": null,
"transcript": "NM_013275.6",
"protein_id": "NP_037407.4",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2663,
"cds_start": -4,
"cds_end": null,
"cds_length": 7992,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9301,
"mane_select": "ENST00000301030.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ANKRD11",
"gene_hgnc_id": 21316,
"hgvs_c": "c.-60+38273C>G",
"hgvs_p": null,
"transcript": "ENST00000301030.10",
"protein_id": "ENSP00000301030.4",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 2663,
"cds_start": -4,
"cds_end": null,
"cds_length": 7992,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9301,
"mane_select": "NM_013275.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANKRD11",
"gene_hgnc_id": 21316,
"hgvs_c": "c.-60+38273C>G",
"hgvs_p": null,
"transcript": "ENST00000378330.7",
"protein_id": "ENSP00000367581.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 2663,
"cds_start": -4,
"cds_end": null,
"cds_length": 7992,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9131,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ENSG00000288715",
"gene_hgnc_id": null,
"hgvs_c": "c.9+38273C>G",
"hgvs_p": null,
"transcript": "ENST00000711617.1",
"protein_id": "ENSP00000518812.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 12,
"cds_start": -4,
"cds_end": null,
"cds_length": 39,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 39,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ANKRD11",
"gene_hgnc_id": 21316,
"hgvs_c": "c.-60+38273C>G",
"hgvs_p": null,
"transcript": "NM_001256182.2",
"protein_id": "NP_001243111.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2663,
"cds_start": -4,
"cds_end": null,
"cds_length": 7992,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9372,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ANKRD11",
"gene_hgnc_id": 21316,
"hgvs_c": "c.-57+38273C>G",
"hgvs_p": null,
"transcript": "NM_001256183.2",
"protein_id": "NP_001243112.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2663,
"cds_start": -4,
"cds_end": null,
"cds_length": 7992,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9298,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ANKRD11",
"gene_hgnc_id": 21316,
"hgvs_c": "c.-57+38273C>G",
"hgvs_p": null,
"transcript": "ENST00000642600.2",
"protein_id": "ENSP00000495226.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2663,
"cds_start": -4,
"cds_end": null,
"cds_length": 7992,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9227,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ANKRD11",
"gene_hgnc_id": 21316,
"hgvs_c": "c.-60+38273C>G",
"hgvs_p": null,
"transcript": "ENST00000642443.1",
"protein_id": "ENSP00000493644.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 943,
"cds_start": -4,
"cds_end": null,
"cds_length": 2834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2915,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ANKRD11",
"gene_hgnc_id": 21316,
"hgvs_c": "c.-60+38273C>G",
"hgvs_p": null,
"transcript": "ENST00000646975.1",
"protein_id": "ENSP00000495608.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 272,
"cds_start": -4,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1179,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ANKRD11",
"gene_hgnc_id": 21316,
"hgvs_c": "c.-60+38273C>G",
"hgvs_p": null,
"transcript": "ENST00000642695.1",
"protein_id": "ENSP00000495449.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 267,
"cds_start": -4,
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"cds_length": 804,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ANKRD11",
"gene_hgnc_id": 21316,
"hgvs_c": "c.-57+38273C>G",
"hgvs_p": null,
"transcript": "ENST00000644784.1",
"protein_id": "ENSP00000496419.1",
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"cds_start": -4,
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 4,
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"gene_symbol": "ANKRD11",
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"hgvs_c": "c.-60+38273C>G",
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"transcript": "ENST00000647238.1",
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
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"gene_symbol": "ANKRD11",
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"hgvs_c": "c.9+38273C>G",
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"transcript": "ENST00000646166.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "ANKRD11",
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"hgvs_c": "c.-60+38273C>G",
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"transcript": "ENST00000644045.1",
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},
{
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],
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"gene_symbol": "ANKRD11",
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"hgvs_c": "c.-113+38273C>G",
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"transcript": "ENST00000647213.1",
"protein_id": "ENSP00000495399.1",
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},
{
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"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "LOC128462377",
"gene_hgnc_id": null,
"hgvs_c": "c.9+38273C>G",
"hgvs_p": null,
"transcript": "NM_001417603.1",
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},
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],
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"gene_symbol": "ENSG00000288715",
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"hgvs_c": "c.9+38273C>G",
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"transcript": "ENST00000683497.1",
"protein_id": "ENSP00000507632.1",
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},
{
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],
"exon_rank": null,
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"intron_rank_end": null,
"gene_symbol": "LOC128462377",
"gene_hgnc_id": null,
"hgvs_c": "c.9+38273C>G",
"hgvs_p": null,
"transcript": "NM_001416403.1",
"protein_id": "NP_001403332.1",
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},
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],
"exon_rank": null,
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"exon_count": 14,
"intron_rank": 2,
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"gene_symbol": "ANKRD11",
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"hgvs_c": "n.-57+38273C>G",
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"transcript": "ENST00000330736.10",
"protein_id": "ENSP00000330815.5",
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},
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],
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},
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],
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},
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"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "ANKRD11",
"gene_hgnc_id": 21316,
"hgvs_c": "n.241+38273C>G",
"hgvs_p": null,
"transcript": "ENST00000562816.5",
"protein_id": null,
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"feature": null
},
{
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"canonical": false,
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ANKRD11",
"gene_hgnc_id": 21316,
"hgvs_c": "n.162-6877C>G",
"hgvs_p": null,
"transcript": "ENST00000566973.1",
"protein_id": null,
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},
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}
],
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}