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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-32208837-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=32208837&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 32208837,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000545287.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.1739+528G>A",
"hgvs_p": null,
"transcript": "NM_001033566.3",
"protein_id": "NP_001028738.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 659,
"cds_start": -4,
"cds_end": null,
"cds_length": 1980,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3165,
"mane_select": "ENST00000545287.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.1739+528G>A",
"hgvs_p": null,
"transcript": "ENST00000545287.7",
"protein_id": "ENSP00000439737.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 659,
"cds_start": -4,
"cds_end": null,
"cds_length": 1980,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3165,
"mane_select": "NM_001033566.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.1740-513G>A",
"hgvs_p": null,
"transcript": "ENST00000358365.7",
"protein_id": "ENSP00000351132.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 691,
"cds_start": -4,
"cds_end": null,
"cds_length": 2076,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3297,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.1739+528G>A",
"hgvs_p": null,
"transcript": "ENST00000333942.10",
"protein_id": "ENSP00000334724.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 618,
"cds_start": -4,
"cds_end": null,
"cds_length": 1857,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3133,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.1676+528G>A",
"hgvs_p": null,
"transcript": "ENST00000354266.7",
"protein_id": "ENSP00000346215.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 597,
"cds_start": -4,
"cds_end": null,
"cds_length": 1794,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2919,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "n.*1707+528G>A",
"hgvs_p": null,
"transcript": "ENST00000578205.5",
"protein_id": "ENSP00000462612.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2771,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "n.1739+528G>A",
"hgvs_p": null,
"transcript": "ENST00000581031.5",
"protein_id": "ENSP00000464094.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3013,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.*524G>A",
"hgvs_p": null,
"transcript": "ENST00000581094.5",
"protein_id": "ENSP00000462669.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 580,
"cds_start": -4,
"cds_end": null,
"cds_length": 1743,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3231,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.1740-513G>A",
"hgvs_p": null,
"transcript": "NM_001033568.3",
"protein_id": "NP_001028740.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 691,
"cds_start": -4,
"cds_end": null,
"cds_length": 2076,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3261,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.1740-513G>A",
"hgvs_p": null,
"transcript": "NM_001288754.2",
"protein_id": "NP_001275683.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 650,
"cds_start": -4,
"cds_end": null,
"cds_length": 1953,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3138,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.1740-513G>A",
"hgvs_p": null,
"transcript": "ENST00000394692.6",
"protein_id": "ENSP00000378184.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 650,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.1739+528G>A",
"hgvs_p": null,
"transcript": "ENST00000581148.2",
"protein_id": "ENSP00000467272.2",
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"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 18,
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"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.1739+528G>A",
"hgvs_p": null,
"transcript": "NM_018307.5",
"protein_id": "NP_060777.3",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.1676+528G>A",
"hgvs_p": null,
"transcript": "NM_001288755.2",
"protein_id": "NP_001275684.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 19,
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"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.1359-513G>A",
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"transcript": "NM_001288758.2",
"protein_id": "NP_001275687.1",
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"cds_start": -4,
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"mane_select": null,
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"feature": null
},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.1358+528G>A",
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"transcript": "NM_001033567.3",
"protein_id": "NP_001028739.2",
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},
{
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],
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"gene_symbol": "RHOT1",
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"hgvs_c": "c.162-513G>A",
"hgvs_p": null,
"transcript": "ENST00000652713.1",
"protein_id": "ENSP00000498380.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 4,
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"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "c.488+528G>A",
"hgvs_p": null,
"transcript": "ENST00000582602.5",
"protein_id": "ENSP00000464851.1",
"transcript_support_level": 3,
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"mane_select": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 3,
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"gene_symbol": "RHOT1",
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"hgvs_c": "c.359+528G>A",
"hgvs_p": null,
"transcript": "ENST00000580392.5",
"protein_id": "ENSP00000463532.1",
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},
{
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"strand": true,
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],
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"intron_rank": 1,
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"gene_symbol": "RHOT1",
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"hgvs_c": "c.8+528G>A",
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"transcript": "ENST00000584852.1",
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},
{
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"strand": true,
"consequences": [
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],
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"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "n.*1708-513G>A",
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"transcript": "ENST00000583994.5",
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "n.*212+528G>A",
"hgvs_p": null,
"transcript": "ENST00000584692.1",
"protein_id": "ENSP00000464674.1",
"transcript_support_level": 2,
"aa_start": null,
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"cdna_length": 680,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RHOT1",
"gene_hgnc_id": 21168,
"hgvs_c": "n.1930+528G>A",
"hgvs_p": null,
"transcript": "NR_110083.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"mane_select": null,
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},
{
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