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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-35617036-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=35617036&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 35617036,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000610402.5",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "AP2B1",
"gene_hgnc_id": 563,
"hgvs_c": "c.526-7361C>T",
"hgvs_p": null,
"transcript": "NM_001030006.2",
"protein_id": "NP_001025177.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 951,
"cds_start": -4,
"cds_end": null,
"cds_length": 2856,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5700,
"mane_select": "ENST00000610402.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "AP2B1",
"gene_hgnc_id": 563,
"hgvs_c": "c.526-7361C>T",
"hgvs_p": null,
"transcript": "ENST00000610402.5",
"protein_id": "ENSP00000483185.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 951,
"cds_start": -4,
"cds_end": null,
"cds_length": 2856,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5700,
"mane_select": "NM_001030006.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "AP2B1",
"gene_hgnc_id": 563,
"hgvs_c": "c.526-7361C>T",
"hgvs_p": null,
"transcript": "ENST00000618940.4",
"protein_id": "ENSP00000482835.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 951,
"cds_start": -4,
"cds_end": null,
"cds_length": 2856,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3415,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "AP2B1",
"gene_hgnc_id": 563,
"hgvs_c": "c.526-7361C>T",
"hgvs_p": null,
"transcript": "ENST00000621914.4",
"protein_id": "ENSP00000482315.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 937,
"cds_start": -4,
"cds_end": null,
"cds_length": 2814,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5702,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "AP2B1",
"gene_hgnc_id": 563,
"hgvs_c": "c.526-7361C>T",
"hgvs_p": null,
"transcript": "ENST00000612116.5",
"protein_id": "ENSP00000478115.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 676,
"cds_start": -4,
"cds_end": null,
"cds_length": 2031,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3483,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "AP2B1",
"gene_hgnc_id": 563,
"hgvs_c": "n.*462-7361C>T",
"hgvs_p": null,
"transcript": "ENST00000620039.4",
"protein_id": "ENSP00000481246.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cds_length": null,
"cdna_start": null,
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"cdna_length": 3428,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "AP2B1",
"gene_hgnc_id": 563,
"hgvs_c": "c.526-7361C>T",
"hgvs_p": null,
"transcript": "NM_001282.3",
"protein_id": "NP_001273.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 937,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "AP2B1",
"gene_hgnc_id": 563,
"hgvs_c": "c.412-7361C>T",
"hgvs_p": null,
"transcript": "ENST00000616681.4",
"protein_id": "ENSP00000484708.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 913,
"cds_start": -4,
"cds_end": null,
"cds_length": 2742,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3267,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "AP2B1",
"gene_hgnc_id": 563,
"hgvs_c": "c.526-7361C>T",
"hgvs_p": null,
"transcript": "ENST00000612035.4",
"protein_id": "ENSP00000482825.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 676,
"cds_start": -4,
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"cds_length": 2031,
"cdna_start": null,
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"mane_select": null,
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},
{
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],
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"gene_symbol": "AP2B1",
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"hgvs_c": "c.526-7361C>T",
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"transcript": "ENST00000614600.4",
"protein_id": "ENSP00000479691.1",
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},
{
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"consequences": [
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],
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"gene_symbol": "AP2B1",
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"transcript": "ENST00000616784.4",
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},
{
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],
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],
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],
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}
],
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}