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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-45830530-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=45830530&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 45830530,
"ref": "T",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "ENST00000314537.10",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "c.669T>C",
"hgvs_p": "p.Thr223Thr",
"transcript": "NM_004382.5",
"protein_id": "NP_004373.2",
"transcript_support_level": null,
"aa_start": 223,
"aa_end": null,
"aa_length": 415,
"cds_start": 669,
"cds_end": null,
"cds_length": 1248,
"cdna_start": 894,
"cdna_end": null,
"cdna_length": 2537,
"mane_select": "ENST00000314537.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "c.669T>C",
"hgvs_p": "p.Thr223Thr",
"transcript": "ENST00000314537.10",
"protein_id": "ENSP00000326060.6",
"transcript_support_level": 1,
"aa_start": 223,
"aa_end": null,
"aa_length": 415,
"cds_start": 669,
"cds_end": null,
"cds_length": 1248,
"cdna_start": 894,
"cdna_end": null,
"cdna_length": 2537,
"mane_select": "NM_004382.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "c.756T>C",
"hgvs_p": "p.Thr252Thr",
"transcript": "ENST00000398285.7",
"protein_id": "ENSP00000381333.3",
"transcript_support_level": 1,
"aa_start": 252,
"aa_end": null,
"aa_length": 444,
"cds_start": 756,
"cds_end": null,
"cds_length": 1335,
"cdna_start": 756,
"cdna_end": null,
"cdna_length": 2399,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "c.669T>C",
"hgvs_p": "p.Thr223Thr",
"transcript": "ENST00000577353.5",
"protein_id": "ENSP00000462016.1",
"transcript_support_level": 1,
"aa_start": 223,
"aa_end": null,
"aa_length": 401,
"cds_start": 669,
"cds_end": null,
"cds_length": 1206,
"cdna_start": 669,
"cdna_end": null,
"cdna_length": 1206,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "c.549T>C",
"hgvs_p": "p.Thr183Thr",
"transcript": "ENST00000352855.9",
"protein_id": "ENSP00000344068.5",
"transcript_support_level": 1,
"aa_start": 183,
"aa_end": null,
"aa_length": 375,
"cds_start": 549,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 567,
"cdna_end": null,
"cdna_length": 1146,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LINC02210-CRHR1",
"gene_hgnc_id": 51483,
"hgvs_c": "c.144T>C",
"hgvs_p": "p.Thr48Thr",
"transcript": "ENST00000634540.1",
"protein_id": "ENSP00000488912.1",
"transcript_support_level": 2,
"aa_start": 48,
"aa_end": null,
"aa_length": 240,
"cds_start": 144,
"cds_end": null,
"cds_length": 723,
"cdna_start": 1054,
"cdna_end": null,
"cdna_length": 2695,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "c.144T>C",
"hgvs_p": "p.Thr48Thr",
"transcript": "ENST00000580876.6",
"protein_id": "ENSP00000516345.1",
"transcript_support_level": 1,
"aa_start": 48,
"aa_end": null,
"aa_length": 211,
"cds_start": 144,
"cds_end": null,
"cds_length": 636,
"cdna_start": 2017,
"cdna_end": null,
"cdna_length": 3502,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "n.884T>C",
"hgvs_p": null,
"transcript": "ENST00000580955.6",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2494,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "n.463T>C",
"hgvs_p": null,
"transcript": "ENST00000619154.4",
"protein_id": "ENSP00000484545.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2370,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "c.756T>C",
"hgvs_p": "p.Thr252Thr",
"transcript": "NM_001145146.2",
"protein_id": "NP_001138618.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 444,
"cds_start": 756,
"cds_end": null,
"cds_length": 1335,
"cdna_start": 981,
"cdna_end": null,
"cdna_length": 2624,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "c.669T>C",
"hgvs_p": "p.Thr223Thr",
"transcript": "NM_001145148.2",
"protein_id": "NP_001138620.1",
"transcript_support_level": null,
"aa_start": 223,
"aa_end": null,
"aa_length": 401,
"cds_start": 669,
"cds_end": null,
"cds_length": 1206,
"cdna_start": 894,
"cdna_end": null,
"cdna_length": 2495,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "c.549T>C",
"hgvs_p": "p.Thr183Thr",
"transcript": "NM_001145147.2",
"protein_id": "NP_001138619.1",
"transcript_support_level": null,
"aa_start": 183,
"aa_end": null,
"aa_length": 375,
"cds_start": 549,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 774,
"cdna_end": null,
"cdna_length": 2417,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "c.366T>C",
"hgvs_p": "p.Thr122Thr",
"transcript": "NM_001303020.2",
"protein_id": "NP_001289949.1",
"transcript_support_level": null,
"aa_start": 122,
"aa_end": null,
"aa_length": 314,
"cds_start": 366,
"cds_end": null,
"cds_length": 945,
"cdna_start": 808,
"cdna_end": null,
"cdna_length": 2451,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LINC02210-CRHR1",
"gene_hgnc_id": 51483,
"hgvs_c": "c.366T>C",
"hgvs_p": "p.Thr122Thr",
"transcript": "NM_001303016.1",
"protein_id": "NP_001289945.1",
"transcript_support_level": null,
"aa_start": 122,
"aa_end": null,
"aa_length": 285,
"cds_start": 366,
"cds_end": null,
"cds_length": 858,
"cdna_start": 1015,
"cdna_end": null,
"cdna_length": 2522,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LINC02210-CRHR1",
"gene_hgnc_id": 51483,
"hgvs_c": "c.144T>C",
"hgvs_p": "p.Thr48Thr",
"transcript": "NM_001256299.3",
"protein_id": "NP_001243228.1",
"transcript_support_level": null,
"aa_start": 48,
"aa_end": null,
"aa_length": 240,
"cds_start": 144,
"cds_end": null,
"cds_length": 723,
"cdna_start": 1052,
"cdna_end": null,
"cdna_length": 2695,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "c.144T>C",
"hgvs_p": "p.Thr48Thr",
"transcript": "NM_001303018.2",
"protein_id": "NP_001289947.1",
"transcript_support_level": null,
"aa_start": 48,
"aa_end": null,
"aa_length": 240,
"cds_start": 144,
"cds_end": null,
"cds_length": 723,
"cdna_start": 688,
"cdna_end": null,
"cdna_length": 2331,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "n.583T>C",
"hgvs_p": null,
"transcript": "ENST00000339069.9",
"protein_id": "ENSP00000340522.7",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2490,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "n.*146T>C",
"hgvs_p": null,
"transcript": "ENST00000347197.9",
"protein_id": "ENSP00000239167.7",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2462,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "n.131T>C",
"hgvs_p": null,
"transcript": "ENST00000581479.1",
"protein_id": null,
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 606,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "n.727T>C",
"hgvs_p": null,
"transcript": "ENST00000582766.5",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 828,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "n.944T>C",
"hgvs_p": null,
"transcript": "ENST00000705340.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2554,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "n.*346T>C",
"hgvs_p": null,
"transcript": "ENST00000705341.1",
"protein_id": "ENSP00000516114.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2732,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRHR1",
"gene_hgnc_id": 2357,
"hgvs_c": "n.769T>C",
"hgvs_p": null,
"transcript": "ENST00000705342.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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{
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}
],
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}