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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 17-76737321-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=76737321&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "17",
      "pos": 76737321,
      "ref": "G",
      "alt": "A",
      "effect": "5_prime_UTR_variant",
      "transcript": "ENST00000359995.10",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SRSF2",
          "gene_hgnc_id": 10783,
          "hgvs_c": "c.-161C>T",
          "hgvs_p": null,
          "transcript": "NM_001195427.2",
          "protein_id": "NP_001182356.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 221,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 666,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1888,
          "mane_select": "ENST00000359995.10",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SRSF2",
          "gene_hgnc_id": 10783,
          "hgvs_c": "c.-161C>T",
          "hgvs_p": null,
          "transcript": "ENST00000359995.10",
          "protein_id": "ENSP00000353089.5",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 221,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 666,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1888,
          "mane_select": "NM_001195427.2",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SRSF2",
          "gene_hgnc_id": 10783,
          "hgvs_c": "c.-161C>T",
          "hgvs_p": null,
          "transcript": "ENST00000392485.2",
          "protein_id": "ENSP00000376276.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 221,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 666,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2885,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MFSD11",
          "gene_hgnc_id": 25458,
          "hgvs_c": "c.-72+230G>A",
          "hgvs_p": null,
          "transcript": "ENST00000621483.4",
          "protein_id": "ENSP00000485005.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 449,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1350,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2850,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000267168",
          "gene_hgnc_id": null,
          "hgvs_c": "c.239-961G>A",
          "hgvs_p": null,
          "transcript": "ENST00000587459.1",
          "protein_id": "ENSP00000466829.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 100,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 303,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 479,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MFSD11",
          "gene_hgnc_id": 25458,
          "hgvs_c": "c.-72+230G>A",
          "hgvs_p": null,
          "transcript": "ENST00000591864.1",
          "protein_id": "ENSP00000467375.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 41,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 126,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 446,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SRSF2",
          "gene_hgnc_id": 10783,
          "hgvs_c": "n.-161C>T",
          "hgvs_p": null,
          "transcript": "ENST00000452355.7",
          "protein_id": "ENSP00000391278.3",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1357,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SRSF2",
          "gene_hgnc_id": 10783,
          "hgvs_c": "n.11C>T",
          "hgvs_p": null,
          "transcript": "NR_036608.2",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1992,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SRSF2",
          "gene_hgnc_id": 10783,
          "hgvs_c": "n.91C>T",
          "hgvs_p": null,
          "transcript": "XR_002958055.2",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1852,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SRSF2",
          "gene_hgnc_id": 10783,
          "hgvs_c": "n.91C>T",
          "hgvs_p": null,
          "transcript": "XR_429913.5",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 1470,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SRSF2",
          "gene_hgnc_id": 10783,
          "hgvs_c": "n.91C>T",
          "hgvs_p": null,
          "transcript": "XR_429914.5",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 1574,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SRSF2",
          "gene_hgnc_id": 10783,
          "hgvs_c": "c.-161C>T",
          "hgvs_p": null,
          "transcript": "NM_003016.5",
          "protein_id": "NP_003007.2",
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          "aa_start": null,
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          "aa_length": 221,
          "cds_start": -4,
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          "cdna_start": null,
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          "mane_select": null,
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        },
        {
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          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
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          "consequences": [
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          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
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          "gene_symbol": "SRSF2",
          "gene_hgnc_id": 10783,
          "hgvs_c": "c.-161C>T",
          "hgvs_p": null,
          "transcript": "ENST00000358156.7",
          "protein_id": "ENSP00000350877.7",
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          "aa_length": 214,
          "cds_start": -4,
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          "cds_length": 645,
          "cdna_start": null,
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          "feature": null
        },
        {
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          "consequences": [
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          ],
          "exon_rank": 1,
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          "exon_count": 3,
          "intron_rank": null,
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          "gene_symbol": "SRSF2",
          "gene_hgnc_id": 10783,
          "hgvs_c": "c.-161C>T",
          "hgvs_p": null,
          "transcript": "ENST00000508921.7",
          "protein_id": "ENSP00000441780.2",
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          "aa_start": null,
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          "cds_start": -4,
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          "cds_length": 630,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": null,
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        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
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          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SRSF2",
          "gene_hgnc_id": 10783,
          "hgvs_c": "c.-161C>T",
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        {
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          ],
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          "intron_rank": null,
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          "gene_symbol": "SRSF2",
          "gene_hgnc_id": 10783,
          "hgvs_c": "n.-161C>T",
          "hgvs_p": null,
          "transcript": "ENST00000452355.7",
          "protein_id": "ENSP00000391278.3",
          "transcript_support_level": 5,
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          "mane_select": null,
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          "feature": null
        },
        {
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          "canonical": false,
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          "strand": true,
          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 14,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MFSD11",
          "gene_hgnc_id": 25458,
          "hgvs_c": "c.-72+230G>A",
          "hgvs_p": null,
          "transcript": "NM_001242534.3",
          "protein_id": "NP_001229463.1",
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          "cdna_start": null,
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          "biotype": null,
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        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 14,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MFSD11",
          "gene_hgnc_id": 25458,
          "hgvs_c": "c.-72+235G>A",
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        {
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          ],
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          "intron_rank": 2,
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          "gene_symbol": "MFSD11",
          "gene_hgnc_id": 25458,
          "hgvs_c": "c.-72+230G>A",
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          "transcript": "ENST00000586622.5",
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        {
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          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 13,
          "intron_rank": 1,
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          "gene_symbol": "MFSD11",
          "gene_hgnc_id": 25458,
          "hgvs_c": "n.458+230G>A",
          "hgvs_p": null,
          "transcript": "NR_148229.2",
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          "feature": null
        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MFSD11",
          "gene_hgnc_id": 25458,
          "hgvs_c": "n.458+230G>A",
          "hgvs_p": null,
          "transcript": "NR_148230.2",
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      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
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  "message": null
}