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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-7944637-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=7944637&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 7944637,
"ref": "C",
"alt": "T",
"effect": "missense_variant,splice_region_variant",
"transcript": "NM_001037144.7",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "NM_053051.5",
"protein_id": "NP_444279.2",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 903,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2712,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000563694.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_053051.5"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "ENST00000563694.6",
"protein_id": "ENSP00000456335.1",
"transcript_support_level": 1,
"aa_start": 578,
"aa_end": null,
"aa_length": 903,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2712,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_053051.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000563694.6"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "ENST00000380262.7",
"protein_id": "ENSP00000369614.3",
"transcript_support_level": 1,
"aa_start": 578,
"aa_end": null,
"aa_length": 925,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2778,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000380262.7"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "ENST00000961850.1",
"protein_id": "ENSP00000631909.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 955,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2868,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961850.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "ENST00000961848.1",
"protein_id": "ENSP00000631907.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 933,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2802,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961848.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "ENST00000881814.1",
"protein_id": "ENSP00000551873.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 932,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2799,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881814.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "NM_001037144.7",
"protein_id": "NP_001032221.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 925,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2778,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001037144.7"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1700C>T",
"hgvs_p": "p.Pro567Leu",
"transcript": "ENST00000961847.1",
"protein_id": "ENSP00000631906.1",
"transcript_support_level": null,
"aa_start": 567,
"aa_end": null,
"aa_length": 915,
"cds_start": 1700,
"cds_end": null,
"cds_length": 2748,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961847.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "NM_001330124.3",
"protein_id": "NP_001317053.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 904,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2715,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001330124.3"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "NM_001353206.2",
"protein_id": "NP_001340135.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 904,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2715,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353206.2"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "NM_001353208.2",
"protein_id": "NP_001340137.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 904,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2715,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353208.2"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "NM_001353209.1",
"protein_id": "NP_001340138.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 904,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2715,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353209.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "ENST00000565740.5",
"protein_id": "ENSP00000454840.1",
"transcript_support_level": 5,
"aa_start": 578,
"aa_end": null,
"aa_length": 904,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2715,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000565740.5"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "NM_001353203.2",
"protein_id": "NP_001340132.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 903,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2712,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353203.2"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "NM_001353207.1",
"protein_id": "NP_001340136.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 903,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2712,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353207.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "ENST00000881813.1",
"protein_id": "ENSP00000551872.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 903,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2712,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881813.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1700C>T",
"hgvs_p": "p.Pro567Leu",
"transcript": "ENST00000961846.1",
"protein_id": "ENSP00000631905.1",
"transcript_support_level": null,
"aa_start": 567,
"aa_end": null,
"aa_length": 893,
"cds_start": 1700,
"cds_end": null,
"cds_length": 2682,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961846.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1700C>T",
"hgvs_p": "p.Pro567Leu",
"transcript": "ENST00000961851.1",
"protein_id": "ENSP00000631910.1",
"transcript_support_level": null,
"aa_start": 567,
"aa_end": null,
"aa_length": 892,
"cds_start": 1700,
"cds_end": null,
"cds_length": 2679,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961851.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1667C>T",
"hgvs_p": "p.Pro556Leu",
"transcript": "ENST00000961849.1",
"protein_id": "ENSP00000631908.1",
"transcript_support_level": null,
"aa_start": 556,
"aa_end": null,
"aa_length": 881,
"cds_start": 1667,
"cds_end": null,
"cds_length": 2646,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961849.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1733C>T",
"hgvs_p": "p.Pro578Leu",
"transcript": "NM_001353202.2",
"protein_id": "NP_001340131.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 871,
"cds_start": 1733,
"cds_end": null,
"cds_length": 2616,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353202.2"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTROB",
"gene_hgnc_id": 29616,
"hgvs_c": "c.1466C>T",
"hgvs_p": "p.Pro489Leu",
"transcript": "NM_001353205.2",
"protein_id": "NP_001340134.1",
"transcript_support_level": null,
"aa_start": 489,
"aa_end": null,
"aa_length": 815,
"cds_start": 1466,
"cds_end": null,
"cds_length": 2448,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353205.2"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
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}