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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-82450939-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=82450939&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 82450939,
"ref": "C",
"alt": "T",
"effect": "non_coding_transcript_exon_variant",
"transcript": "ENST00000658363.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 1,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000287193",
"gene_hgnc_id": null,
"hgvs_c": "n.29C>T",
"hgvs_p": null,
"transcript": "ENST00000658363.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1303,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-278G>A",
"hgvs_p": null,
"transcript": "NM_001033046.4",
"protein_id": "NP_001028218.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 187,
"cds_start": -4,
"cds_end": null,
"cds_length": 564,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2073,
"mane_select": "ENST00000306645.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-278G>A",
"hgvs_p": null,
"transcript": "ENST00000306645.10",
"protein_id": "ENSP00000307765.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 187,
"cds_start": -4,
"cds_end": null,
"cds_length": 564,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2073,
"mane_select": "NM_001033046.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "n.-110G>A",
"hgvs_p": null,
"transcript": "ENST00000578941.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1079,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-278G>A",
"hgvs_p": null,
"transcript": "ENST00000583617.5",
"protein_id": "ENSP00000462515.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 190,
"cds_start": -4,
"cds_end": null,
"cds_length": 573,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 866,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-328G>A",
"hgvs_p": null,
"transcript": "NM_001100407.3",
"protein_id": "NP_001093877.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 187,
"cds_start": -4,
"cds_end": null,
"cds_length": 564,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2123,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-548G>A",
"hgvs_p": null,
"transcript": "NM_001193653.2",
"protein_id": "NP_001180582.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 187,
"cds_start": -4,
"cds_end": null,
"cds_length": 564,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2343,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-498G>A",
"hgvs_p": null,
"transcript": "NM_001193654.2",
"protein_id": "NP_001180583.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 187,
"cds_start": -4,
"cds_end": null,
"cds_length": 564,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2293,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-495G>A",
"hgvs_p": null,
"transcript": "NM_001193657.2",
"protein_id": "NP_001180586.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 187,
"cds_start": -4,
"cds_end": null,
"cds_length": 564,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2290,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-548G>A",
"hgvs_p": null,
"transcript": "ENST00000437807.6",
"protein_id": "ENSP00000388909.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 187,
"cds_start": -4,
"cds_end": null,
"cds_length": 564,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2242,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-495G>A",
"hgvs_p": null,
"transcript": "ENST00000577696.6",
"protein_id": "ENSP00000463215.2",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 187,
"cds_start": -4,
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"cds_length": 564,
"cdna_start": null,
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"cdna_length": 2174,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-328G>A",
"hgvs_p": null,
"transcript": "ENST00000578919.6",
"protein_id": "ENSP00000464080.1",
"transcript_support_level": 3,
"aa_start": null,
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"aa_length": 187,
"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-498G>A",
"hgvs_p": null,
"transcript": "ENST00000585064.5",
"protein_id": "ENSP00000463846.1",
"transcript_support_level": 2,
"aa_start": null,
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"aa_length": 187,
"cds_start": -4,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-334G>A",
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"transcript": "ENST00000585080.5",
"protein_id": "ENSP00000462529.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": null,
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"gene_symbol": "CYBC1",
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"hgvs_c": "c.-278G>A",
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"transcript": "ENST00000698821.1",
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
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"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-278G>A",
"hgvs_p": null,
"transcript": "NM_001100408.3",
"protein_id": "NP_001093878.1",
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},
{
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],
"exon_rank": null,
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"intron_rank": null,
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"gene_symbol": "CYBC1",
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"hgvs_c": "c.-278G>A",
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"transcript": "ENST00000434650.6",
"protein_id": "ENSP00000401626.2",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": null,
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"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-1102G>A",
"hgvs_p": null,
"transcript": "ENST00000585115.2",
"protein_id": "ENSP00000513957.1",
"transcript_support_level": 4,
"aa_start": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
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"hgvs_c": "c.-384G>A",
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"transcript": "ENST00000698820.1",
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},
{
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"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "CYBC1",
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"hgvs_c": "c.-278G>A",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": null,
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"gene_symbol": "CYBC1",
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"hgvs_c": "c.-278G>A",
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"transcript": "ENST00000578913.5",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-445G>A",
"hgvs_p": null,
"transcript": "ENST00000577471.5",
"protein_id": "ENSP00000463475.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 118,
"cds_start": -4,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CYBC1",
"gene_hgnc_id": 28672,
"hgvs_c": "c.-384G>A",
"hgvs_p": null,
"transcript": "ENST00000577834.5",
"protein_id": "ENSP00000464442.1",
"transcript_support_level": 4,
"aa_start": null,
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"aa_length": 116,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
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},
{
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{
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}
],
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}