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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 17-82757178-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=82757178&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "17",
      "pos": 82757178,
      "ref": "T",
      "alt": "C",
      "effect": "intron_variant",
      "transcript": "NM_005993.5",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TBCD",
          "gene_hgnc_id": 11581,
          "hgvs_c": "c.235+963T>C",
          "hgvs_p": null,
          "transcript": "NM_005993.5",
          "protein_id": "NP_005984.3",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1192,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 3579,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000355528.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_005993.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TBCD",
          "gene_hgnc_id": 11581,
          "hgvs_c": "c.235+963T>C",
          "hgvs_p": null,
          "transcript": "ENST00000355528.9",
          "protein_id": "ENSP00000347719.4",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1192,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 3579,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_005993.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000355528.9"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TBCD",
          "gene_hgnc_id": 11581,
          "hgvs_c": "c.235+963T>C",
          "hgvs_p": null,
          "transcript": "ENST00000684760.1",
          "protein_id": "ENSP00000507696.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1281,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 3846,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000684760.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TBCD",
          "gene_hgnc_id": 11581,
          "hgvs_c": "c.235+963T>C",
          "hgvs_p": null,
          "transcript": "ENST00000684349.1",
          "protein_id": "ENSP00000508067.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1254,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 3765,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000684349.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TBCD",
          "gene_hgnc_id": 11581,
          "hgvs_c": "c.235+963T>C",
          "hgvs_p": null,
          "transcript": "ENST00000539345.6",
          "protein_id": "ENSP00000440671.2",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1230,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 3693,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000539345.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TBCD",
          "gene_hgnc_id": 11581,
          "hgvs_c": "c.235+963T>C",
          "hgvs_p": null,
          "transcript": "ENST00000857311.1",
          "protein_id": "ENSP00000527370.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1224,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 3675,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000857311.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TBCD",
          "gene_hgnc_id": 11581,
          "hgvs_c": "c.235+963T>C",
          "hgvs_p": null,
          "transcript": "ENST00000684464.1",
          "protein_id": "ENSP00000508333.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1223,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 3672,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000684464.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TBCD",
          "gene_hgnc_id": 11581,
          "hgvs_c": "c.235+963T>C",
          "hgvs_p": null,
          "transcript": "ENST00000682479.1",
          "protein_id": "ENSP00000508214.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1222,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 3669,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000682479.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TBCD",
          "gene_hgnc_id": 11581,
          "hgvs_c": "c.235+963T>C",
          "hgvs_p": null,
          "transcript": "ENST00000684000.1",
          "protein_id": "ENSP00000506795.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1220,
          "cds_start": null,
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          "cds_length": 3663,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000684000.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "TBCD",
          "gene_hgnc_id": 11581,
          "hgvs_c": "c.184+4801T>C",
          "hgvs_p": null,
          "transcript": "ENST00000959286.1",
          "protein_id": "ENSP00000629345.1",
          "transcript_support_level": null,
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          "aa_length": 1207,
          "cds_start": null,
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          "cds_length": 3624,
          "cdna_start": null,
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          "mane_select": null,
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        {
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          "gene_symbol": "TBCD",
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          "hgvs_c": "c.235+963T>C",
          "hgvs_p": null,
          "transcript": "ENST00000959289.1",
          "protein_id": "ENSP00000629348.1",
          "transcript_support_level": null,
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          "aa_length": 1203,
          "cds_start": null,
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          "cdna_start": null,
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        {
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
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        {
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        {
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          "gene_symbol": "TBCD",
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          "hgvs_c": "c.184+4801T>C",
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          "transcript": "NM_001411101.1",
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        {
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          "gene_symbol": "TBCD",
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        {
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          "gene_symbol": "TBCD",
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          "hgvs_c": "c.235+963T>C",
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        {
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      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
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      "pathogenicity_classification_combined": null,
      "custom_annotations": null
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  "message": null
}