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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 18-77026349-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=77026349&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "18",
"pos": 77026349,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000355994.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "NM_001025101.2",
"protein_id": "NP_001020272.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 304,
"cds_start": -4,
"cds_end": null,
"cds_length": 915,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2738,
"mane_select": "ENST00000355994.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "ENST00000355994.7",
"protein_id": "ENSP00000348273.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 304,
"cds_start": -4,
"cds_end": null,
"cds_length": 915,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2738,
"mane_select": "NM_001025101.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "ENST00000397860.7",
"protein_id": "ENSP00000380958.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 197,
"cds_start": -4,
"cds_end": null,
"cds_length": 594,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4844,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "ENST00000580402.5",
"protein_id": "ENSP00000462223.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 304,
"cds_start": -4,
"cds_end": null,
"cds_length": 915,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 915,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "ENST00000579129.5",
"protein_id": "ENSP00000463780.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 253,
"cds_start": -4,
"cds_end": null,
"cds_length": 762,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1052,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "NM_001025100.2",
"protein_id": "NP_001020271.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 197,
"cds_start": -4,
"cds_end": null,
"cds_length": 594,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4844,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "ENST00000397863.5",
"protein_id": "ENSP00000380961.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 197,
"cds_start": -4,
"cds_end": null,
"cds_length": 594,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4800,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "ENST00000581878.5",
"protein_id": "ENSP00000462374.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 158,
"cds_start": -4,
"cds_end": null,
"cds_length": 478,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 563,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "n.624-9081T>C",
"hgvs_p": null,
"transcript": "ENST00000487778.5",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 913,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "n.333-9081T>C",
"hgvs_p": null,
"transcript": "ENST00000490754.5",
"protein_id": null,
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 531,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "n.395-9081T>C",
"hgvs_p": null,
"transcript": "ENST00000495162.5",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 578,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "n.740-9081T>C",
"hgvs_p": null,
"transcript": "ENST00000497479.1",
"protein_id": null,
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"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "n.326-36289T>C",
"hgvs_p": null,
"transcript": "ENST00000580473.5",
"protein_id": null,
"transcript_support_level": 4,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "XM_047437521.1",
"protein_id": "XP_047293477.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 384,
"cds_start": -4,
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"biotype": null,
"feature": null
},
{
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"strand": false,
"consequences": [
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],
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"intron_rank": 4,
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"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "XM_047437522.1",
"protein_id": "XP_047293478.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 384,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "XM_047437523.1",
"protein_id": "XP_047293479.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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},
{
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],
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"intron_rank": 3,
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"gene_symbol": "MBP",
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"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "XM_047437524.1",
"protein_id": "XP_047293480.1",
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"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 2129,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "XM_047437525.1",
"protein_id": "XP_047293481.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 384,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "XM_047437526.1",
"protein_id": "XP_047293482.1",
"transcript_support_level": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 5,
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"gene_symbol": "MBP",
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"hgvs_c": "c.140-9081T>C",
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"transcript": "XM_047437527.1",
"protein_id": "XP_047293483.1",
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 5,
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"gene_symbol": "MBP",
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"hgvs_c": "c.140-9081T>C",
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"transcript": "XM_047437528.1",
"protein_id": "XP_047293484.1",
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "XM_047437529.1",
"protein_id": "XP_047293485.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 330,
"cds_start": -4,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MBP",
"gene_hgnc_id": 6925,
"hgvs_c": "c.140-9081T>C",
"hgvs_p": null,
"transcript": "XM_047437530.1",
"protein_id": "XP_047293486.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 319,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
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{
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],
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"clinvar_review_status": "",
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"custom_annotations": null
}
],
"message": null
}