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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 19-13926511-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=13926511&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "19",
      "pos": 13926511,
      "ref": "C",
      "alt": "T",
      "effect": "splice_region_variant,intron_variant",
      "transcript": "NM_017721.5",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1941-6C>T",
          "hgvs_p": null,
          "transcript": "NM_017721.5",
          "protein_id": "NP_060191.3",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 951,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2856,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000318003.11",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_017721.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1941-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000318003.11",
          "protein_id": "ENSP00000313601.6",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 951,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2856,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_017721.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000318003.11"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1941-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000589606.5",
          "protein_id": "ENSP00000467526.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 950,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2853,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000589606.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": 12,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "n.*208-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000586955.5",
          "protein_id": "ENSP00000465376.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000586955.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1941-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000870936.1",
          "protein_id": "ENSP00000540995.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 982,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2949,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870936.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1941-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000870939.1",
          "protein_id": "ENSP00000540998.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 957,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2874,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870939.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1977-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000870940.1",
          "protein_id": "ENSP00000540999.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 957,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2874,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870940.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1956-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000870935.1",
          "protein_id": "ENSP00000540994.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 956,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2871,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870935.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1929-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000870942.1",
          "protein_id": "ENSP00000541001.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 953,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2862,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870942.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1944-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000870932.1",
          "protein_id": "ENSP00000540991.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 952,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2859,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870932.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1941-6C>T",
          "hgvs_p": null,
          "transcript": "NM_001411138.1",
          "protein_id": "NP_001398067.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 950,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2853,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001411138.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1938-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000870926.1",
          "protein_id": "ENSP00000540985.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 950,
          "cds_start": null,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000870926.1"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1938-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000870928.1",
          "protein_id": "ENSP00000540987.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 949,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2850,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870928.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1929-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000870924.1",
          "protein_id": "ENSP00000540983.1",
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          "cds_start": null,
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          "cdna_start": null,
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          "biotype": "protein_coding",
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        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1926-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000870925.1",
          "protein_id": "ENSP00000540984.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 946,
          "cds_start": null,
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          "cds_length": 2841,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000870925.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1929-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000870927.1",
          "protein_id": "ENSP00000540986.1",
          "transcript_support_level": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1926-6C>T",
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          "transcript": "ENST00000870930.1",
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        },
        {
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            "intron_variant"
          ],
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          "exon_count": 29,
          "intron_rank": 17,
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          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1941-6C>T",
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          "transcript": "ENST00000870931.1",
          "protein_id": "ENSP00000540990.1",
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          "biotype": "protein_coding",
          "feature": "ENST00000870931.1"
        },
        {
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          "canonical": false,
          "protein_coding": true,
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          "consequences": [
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          ],
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          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1929-24C>T",
          "hgvs_p": null,
          "transcript": "ENST00000870934.1",
          "protein_id": "ENSP00000540993.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 941,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2826,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870934.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "c.1908-6C>T",
          "hgvs_p": null,
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          "canonical": false,
          "protein_coding": false,
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            "intron_variant"
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          "exon_count": 17,
          "intron_rank": 10,
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          "gene_symbol": "CC2D1A",
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          "hgvs_c": "n.1065-6C>T",
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          "mane_select": null,
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        {
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            "intron_variant"
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          "exon_count": 7,
          "intron_rank": 2,
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          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "n.146-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000589224.1",
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          "transcript_support_level": 3,
          "aa_start": null,
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          "aa_length": null,
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          "cds_length": null,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "retained_intron",
          "feature": "ENST00000589224.1"
        },
        {
          "aa_ref": null,
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          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 16,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "n.738-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000679637.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000679637.1"
        },
        {
          "aa_ref": null,
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          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 17,
          "intron_rank": 5,
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          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "n.640-6C>T",
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          "transcript": "ENST00000679937.1",
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          "transcript_support_level": null,
          "aa_start": null,
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          "cds_start": null,
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          "cdna_start": null,
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          "cdna_length": null,
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          "biotype": "retained_intron",
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        },
        {
          "aa_ref": null,
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          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 17,
          "intron_rank": 5,
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          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "n.865-6C>T",
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          "transcript": "ENST00000681428.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "retained_intron",
          "feature": "ENST00000681428.1"
        },
        {
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          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 17,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "CC2D1A",
          "gene_hgnc_id": 30237,
          "hgvs_c": "n.698-6C>T",
          "hgvs_p": null,
          "transcript": "ENST00000681846.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000681846.1"
        }
      ],
      "gene_symbol": "CC2D1A",
      "gene_hgnc_id": 30237,
      "dbsnp": "rs773170502",
      "frequency_reference_population": 0.000006158453,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 9,
      "gnomad_exomes_af": 0.00000615845,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 9,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.9599999785423279,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0.01600000075995922,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "dbscSNV1_RF",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.96,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": -1.682,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0.04,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": 0.0000415571597887137,
      "dbscsnv_ada_prediction": "Benign",
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -2,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong",
      "acmg_by_gene": [
        {
          "score": -2,
          "benign_score": 4,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_017721.5",
          "gene_symbol": "CC2D1A",
          "hgnc_id": 30237,
          "effects": [
            "splice_region_variant",
            "intron_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.1941-6C>T",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "Inborn genetic diseases,not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "US:2",
      "phenotype_combined": "not specified|Inborn genetic diseases",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}