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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-53576890-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=53576890&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 53576890,
"ref": "A",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "ENST00000449416.6",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001079906.2",
"protein_id": "NP_001073375.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 686,
"cdna_end": null,
"cdna_length": 4065,
"mane_select": "ENST00000449416.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "ENST00000449416.6",
"protein_id": "ENSP00000393817.1",
"transcript_support_level": 5,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 686,
"cdna_end": null,
"cdna_length": 4065,
"mane_select": "NM_001079906.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "ENST00000253144.13",
"protein_id": "ENSP00000253144.9",
"transcript_support_level": 1,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 1663,
"cdna_end": null,
"cdna_length": 5042,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "ENST00000504493.6",
"protein_id": "ENSP00000425517.2",
"transcript_support_level": 1,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 650,
"cdna_end": null,
"cdna_length": 1841,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "ENST00000511154.5",
"protein_id": "ENSP00000421014.1",
"transcript_support_level": 1,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 624,
"cdna_end": null,
"cdna_length": 2120,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "ENST00000512387.6",
"protein_id": "ENSP00000421728.1",
"transcript_support_level": 1,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 662,
"cdna_end": null,
"cdna_length": 2161,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "ENST00000513999.5",
"protein_id": "ENSP00000423156.1",
"transcript_support_level": 1,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 699,
"cdna_end": null,
"cdna_length": 1890,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001079907.1",
"protein_id": "NP_001073376.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 772,
"cdna_end": null,
"cdna_length": 4151,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001253798.2",
"protein_id": "NP_001240727.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 911,
"cdna_end": null,
"cdna_length": 4290,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001253799.2",
"protein_id": "NP_001240728.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 881,
"cdna_end": null,
"cdna_length": 4260,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001253800.3",
"protein_id": "NP_001240729.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 900,
"cdna_end": null,
"cdna_length": 4279,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001253801.2",
"protein_id": "NP_001240730.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 662,
"cdna_end": null,
"cdna_length": 4041,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001317113.2",
"protein_id": "NP_001304042.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 622,
"cdna_end": null,
"cdna_length": 4001,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001317114.2",
"protein_id": "NP_001304043.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 983,
"cdna_end": null,
"cdna_length": 4362,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001317115.2",
"protein_id": "NP_001304044.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 716,
"cdna_end": null,
"cdna_length": 4095,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001317116.2",
"protein_id": "NP_001304045.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 529,
"cdna_end": null,
"cdna_length": 3908,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001317117.1",
"protein_id": "NP_001304046.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 692,
"cdna_end": null,
"cdna_length": 4071,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001317118.1",
"protein_id": "NP_001304047.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 773,
"cdna_end": null,
"cdna_length": 4152,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001317119.1",
"protein_id": "NP_001304048.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
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"cdna_start": 742,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001317120.2",
"protein_id": "NP_001304049.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 1635,
"cdna_end": null,
"cdna_length": 5014,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_001317121.1",
"protein_id": "NP_001304050.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 646,
"cdna_end": null,
"cdna_length": 4025,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "NM_018555.6",
"protein_id": "NP_061025.5",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 463,
"cds_start": 330,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 1673,
"cdna_end": null,
"cdna_length": 5052,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF331",
"gene_hgnc_id": 15489,
"hgvs_c": "c.330A>G",
"hgvs_p": "p.Arg110Arg",
"transcript": "ENST00000511593.6",
"protein_id": "ENSP00000427439.1",
"transcript_support_level": 5,
"aa_start": 110,
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{
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"verdict": "Benign",
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{
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"verdict": "Benign",
"transcript": "ENST00000790248.1",
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"inheritance_mode": "",
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}
],
"clinvar_disease": "",
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"clinvar_review_status": "",
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"custom_annotations": null
}
],
"message": null
}