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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-100393748-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=100393748&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PM1",
            "PP3"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "CHST10",
          "hgnc_id": 19650,
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "inheritance_mode": "AR",
          "pathogenic_score": 3,
          "score": 3,
          "transcript": "NM_004854.5",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM1,PP3",
      "acmg_score": 3,
      "allele_count_reference_population": 19,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.8796,
      "alt": "G",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "bayesdelnoaf_score": 0.07,
      "chr": "2",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Pathogenic",
      "computational_score_selected": 0.7663024663925171,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2854,
          "cdna_start": 966,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "NM_004854.5",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000264249.8",
          "protein_coding": true,
          "protein_id": "NP_004845.1",
          "strand": false,
          "transcript": "NM_004854.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2854,
          "cdna_start": 966,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000264249.8",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_004854.5",
          "protein_coding": true,
          "protein_id": "ENSP00000264249.3",
          "strand": false,
          "transcript": "ENST00000264249.8",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1338,
          "cdna_start": 835,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000409701.5",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000387309.1",
          "strand": false,
          "transcript": "ENST00000409701.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 377,
          "aa_ref": "D",
          "aa_start": 211,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2915,
          "cdna_start": 1027,
          "cds_end": null,
          "cds_length": 1134,
          "cds_start": 631,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000972083.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.631G>C",
          "hgvs_p": "p.Asp211His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000642142.1",
          "strand": false,
          "transcript": "ENST00000972083.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2886,
          "cdna_start": 998,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000866824.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000536883.1",
          "strand": false,
          "transcript": "ENST00000866824.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3240,
          "cdna_start": 1354,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000866825.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000536884.1",
          "strand": false,
          "transcript": "ENST00000866825.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2976,
          "cdna_start": 1088,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000866826.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000536885.1",
          "strand": false,
          "transcript": "ENST00000866826.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3417,
          "cdna_start": 1532,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000866827.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000536886.1",
          "strand": false,
          "transcript": "ENST00000866827.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2929,
          "cdna_start": 1043,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000866828.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000536887.1",
          "strand": false,
          "transcript": "ENST00000866828.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2766,
          "cdna_start": 880,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000866829.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000536888.1",
          "strand": false,
          "transcript": "ENST00000866829.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2828,
          "cdna_start": 945,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000866831.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000536890.1",
          "strand": false,
          "transcript": "ENST00000866831.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2797,
          "cdna_start": 917,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000866832.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000536891.1",
          "strand": false,
          "transcript": "ENST00000866832.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3705,
          "cdna_start": 1825,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000866833.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000536892.1",
          "strand": false,
          "transcript": "ENST00000866833.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2854,
          "cdna_start": 966,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000933567.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000603626.1",
          "strand": false,
          "transcript": "ENST00000933567.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3530,
          "cdna_start": 1642,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000933568.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000603627.1",
          "strand": false,
          "transcript": "ENST00000933568.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3612,
          "cdna_start": 1724,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000933569.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000603628.1",
          "strand": false,
          "transcript": "ENST00000933569.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2872,
          "cdna_start": 985,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000933570.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000603629.1",
          "strand": false,
          "transcript": "ENST00000933570.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2574,
          "cdna_start": 686,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000933571.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000603630.1",
          "strand": false,
          "transcript": "ENST00000933571.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "D",
          "aa_start": 190,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2882,
          "cdna_start": 996,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 568,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000933572.1",
          "gene_hgnc_id": 19650,
          "gene_symbol": "CHST10",
          "hgvs_c": "c.568G>C",
          "hgvs_p": "p.Asp190His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.