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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-119464135-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=119464135&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 119464135,
      "ref": "G",
      "alt": "A",
      "effect": "synonymous_variant",
      "transcript": "NM_002980.3",
      "consequences": [
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.624C>T",
          "hgvs_p": "p.Cys208Cys",
          "transcript": "NM_002980.3",
          "protein_id": "NP_002971.2",
          "transcript_support_level": null,
          "aa_start": 208,
          "aa_end": null,
          "aa_length": 440,
          "cds_start": 624,
          "cds_end": null,
          "cds_length": 1323,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000019103.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_002980.3"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.624C>T",
          "hgvs_p": "p.Cys208Cys",
          "transcript": "ENST00000019103.8",
          "protein_id": "ENSP00000019103.6",
          "transcript_support_level": 1,
          "aa_start": 208,
          "aa_end": null,
          "aa_length": 440,
          "cds_start": 624,
          "cds_end": null,
          "cds_length": 1323,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_002980.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000019103.8"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.819C>T",
          "hgvs_p": "p.Cys273Cys",
          "transcript": "ENST00000903274.1",
          "protein_id": "ENSP00000573333.1",
          "transcript_support_level": null,
          "aa_start": 273,
          "aa_end": null,
          "aa_length": 505,
          "cds_start": 819,
          "cds_end": null,
          "cds_length": 1518,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903274.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.624C>T",
          "hgvs_p": "p.Cys208Cys",
          "transcript": "ENST00000903275.1",
          "protein_id": "ENSP00000573334.1",
          "transcript_support_level": null,
          "aa_start": 208,
          "aa_end": null,
          "aa_length": 445,
          "cds_start": 624,
          "cds_end": null,
          "cds_length": 1338,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903275.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.624C>T",
          "hgvs_p": "p.Cys208Cys",
          "transcript": "ENST00000971075.1",
          "protein_id": "ENSP00000641134.1",
          "transcript_support_level": null,
          "aa_start": 208,
          "aa_end": null,
          "aa_length": 443,
          "cds_start": 624,
          "cds_end": null,
          "cds_length": 1332,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000971075.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.624C>T",
          "hgvs_p": "p.Cys208Cys",
          "transcript": "ENST00000903273.1",
          "protein_id": "ENSP00000573332.1",
          "transcript_support_level": null,
          "aa_start": 208,
          "aa_end": null,
          "aa_length": 438,
          "cds_start": 624,
          "cds_end": null,
          "cds_length": 1317,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903273.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.516C>T",
          "hgvs_p": "p.Cys172Cys",
          "transcript": "ENST00000971074.1",
          "protein_id": "ENSP00000641133.1",
          "transcript_support_level": null,
          "aa_start": 172,
          "aa_end": null,
          "aa_length": 404,
          "cds_start": 516,
          "cds_end": null,
          "cds_length": 1215,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000971074.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.624C>T",
          "hgvs_p": "p.Cys208Cys",
          "transcript": "ENST00000971073.1",
          "protein_id": "ENSP00000641132.1",
          "transcript_support_level": null,
          "aa_start": 208,
          "aa_end": null,
          "aa_length": 386,
          "cds_start": 624,
          "cds_end": null,
          "cds_length": 1161,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000971073.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.624C>T",
          "hgvs_p": "p.Cys208Cys",
          "transcript": "ENST00000903276.1",
          "protein_id": "ENSP00000573335.1",
          "transcript_support_level": null,
          "aa_start": 208,
          "aa_end": null,
          "aa_length": 367,
          "cds_start": 624,
          "cds_end": null,
          "cds_length": 1104,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903276.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.699C>T",
          "hgvs_p": "p.Cys233Cys",
          "transcript": "ENST00000627145.1",
          "protein_id": "ENSP00000486987.1",
          "transcript_support_level": 5,
          "aa_start": 233,
          "aa_end": null,
          "aa_length": 242,
          "cds_start": 699,
          "cds_end": null,
          "cds_length": 729,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000627145.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.420C>T",
          "hgvs_p": "p.Cys140Cys",
          "transcript": "ENST00000630739.2",
          "protein_id": "ENSP00000486930.1",
          "transcript_support_level": 5,
          "aa_start": 140,
          "aa_end": null,
          "aa_length": 149,
          "cds_start": 420,
          "cds_end": null,
          "cds_length": 450,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000630739.2"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.624C>T",
          "hgvs_p": "p.Cys208Cys",
          "transcript": "XM_047445399.1",
          "protein_id": "XP_047301355.1",
          "transcript_support_level": null,
          "aa_start": 208,
          "aa_end": null,
          "aa_length": 450,
          "cds_start": 624,
          "cds_end": null,
          "cds_length": 1353,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047445399.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.624C>T",
          "hgvs_p": "p.Cys208Cys",
          "transcript": "XM_011511621.3",
          "protein_id": "XP_011509923.1",
          "transcript_support_level": null,
          "aa_start": 208,
          "aa_end": null,
          "aa_length": 445,
          "cds_start": 624,
          "cds_end": null,
          "cds_length": 1338,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011511621.3"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.624C>T",
          "hgvs_p": "p.Cys208Cys",
          "transcript": "XM_047445400.1",
          "protein_id": "XP_047301356.1",
          "transcript_support_level": null,
          "aa_start": 208,
          "aa_end": null,
          "aa_length": 445,
          "cds_start": 624,
          "cds_end": null,
          "cds_length": 1338,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047445400.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.594C>T",
          "hgvs_p": "p.Cys198Cys",
          "transcript": "XM_017004670.2",
          "protein_id": "XP_016860159.2",
          "transcript_support_level": null,
          "aa_start": 198,
          "aa_end": null,
          "aa_length": 440,
          "cds_start": 594,
          "cds_end": null,
          "cds_length": 1323,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_017004670.2"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.516C>T",
          "hgvs_p": "p.Cys172Cys",
          "transcript": "XM_047445401.1",
          "protein_id": "XP_047301357.1",
          "transcript_support_level": null,
          "aa_start": 172,
          "aa_end": null,
          "aa_length": 414,
          "cds_start": 516,
          "cds_end": null,
          "cds_length": 1245,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047445401.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.450C>T",
          "hgvs_p": "p.Cys150Cys",
          "transcript": "XM_047445402.1",
          "protein_id": "XP_047301358.1",
          "transcript_support_level": null,
          "aa_start": 150,
          "aa_end": null,
          "aa_length": 392,
          "cds_start": 450,
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          "cds_length": 1179,
          "cdna_start": null,
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          "cdna_length": null,
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          "biotype": "protein_coding",
          "feature": "XM_047445402.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.420C>T",
          "hgvs_p": "p.Cys140Cys",
          "transcript": "XM_047445403.1",
          "protein_id": "XP_047301359.1",
          "transcript_support_level": null,
          "aa_start": 140,
          "aa_end": null,
          "aa_length": 382,
          "cds_start": 420,
          "cds_end": null,
          "cds_length": 1149,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047445403.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "c.90C>T",
          "hgvs_p": "p.Cys30Cys",
          "transcript": "XM_047445404.1",
          "protein_id": "XP_047301360.1",
          "transcript_support_level": null,
          "aa_start": 30,
          "aa_end": null,
          "aa_length": 272,
          "cds_start": 90,
          "cds_end": null,
          "cds_length": 819,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047445404.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "n.1304C>T",
          "hgvs_p": null,
          "transcript": "ENST00000485440.1",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000485440.1"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "n.881C>T",
          "hgvs_p": null,
          "transcript": "XR_001738888.2",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "XR_001738888.2"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "n.881C>T",
          "hgvs_p": null,
          "transcript": "XR_001738889.2",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "XR_001738889.2"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "n.881C>T",
          "hgvs_p": null,
          "transcript": "XR_007079571.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "XR_007079571.1"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCTR",
          "gene_hgnc_id": 10608,
          "hgvs_c": "n.881C>T",
          "hgvs_p": null,
          "transcript": "XR_922984.3",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "XR_922984.3"
        }
      ],
      "gene_symbol": "SCTR",
      "gene_hgnc_id": 10608,
      "dbsnp": "rs141567872",
      "frequency_reference_population": 0.0040826844,
      "hom_count_reference_population": 35,
      "allele_count_reference_population": 6590,
      "gnomad_exomes_af": 0.00411408,
      "gnomad_genomes_af": 0.00378136,
      "gnomad_exomes_ac": 6014,
      "gnomad_genomes_ac": 576,
      "gnomad_exomes_homalt": 31,
      "gnomad_genomes_homalt": 4,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.800000011920929,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0.029999999329447746,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.8,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": -0.997,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0.03,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -21,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BP6_Very_Strong,BP7,BS1,BS2",
      "acmg_by_gene": [
        {
          "score": -21,
          "benign_score": 21,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BP6_Very_Strong",
            "BP7",
            "BS1",
            "BS2"
          ],
          "verdict": "Benign",
          "transcript": "NM_002980.3",
          "gene_symbol": "SCTR",
          "hgnc_id": 10608,
          "effects": [
            "synonymous_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.624C>T",
          "hgvs_p": "p.Cys208Cys"
        }
      ],
      "clinvar_disease": "not provided",
      "clinvar_classification": "Benign",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "B:2",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Benign",
      "custom_annotations": null
    }
  ],
  "message": null
}