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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-147943530-G-GAAAAAAAAAAAAAAAAAAAAAAAAAAAA (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=147943530&ref=G&alt=GAAAAAAAAAAAAAAAAAAAAAAAAAAAA&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 147943530,
      "ref": "G",
      "alt": "GAAAAAAAAAAAAAAAAAAAAAAAAAAAA",
      "effect": "intron_variant",
      "transcript": "NM_002552.5",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "ORC4",
          "gene_hgnc_id": 8490,
          "hgvs_c": "c.763-9_763-8insTTTTTTTTTTTTTTTTTTTTTTTTTTTT",
          "hgvs_p": null,
          "transcript": "NM_181741.4",
          "protein_id": "NP_859525.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 436,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1311,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000392857.10",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_181741.4"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "ORC4",
          "gene_hgnc_id": 8490,
          "hgvs_c": "c.763-9_763-8insTTTTTTTTTTTTTTTTTTTTTTTTTTTT",
          "hgvs_p": null,
          "transcript": "ENST00000392857.10",
          "protein_id": "ENSP00000376597.5",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 436,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1311,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_181741.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000392857.10"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "ORC4",
          "gene_hgnc_id": 8490,
          "hgvs_c": "c.763-9_763-8insTTTTTTTTTTTTTTTTTTTTTTTTTTTT",
          "hgvs_p": null,
          "transcript": "ENST00000877934.1",
          "protein_id": "ENSP00000547993.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 461,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1386,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000877934.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": 10,
          "intron_rank_end": null,
          "gene_symbol": "ORC4",
          "gene_hgnc_id": 8490,
          "hgvs_c": "c.763-9_763-8insTTTTTTTTTTTTTTTTTTTTTTTTTTTT",
          "hgvs_p": null,
          "transcript": "NM_001190879.3",
          "protein_id": "NP_001177808.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 436,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1311,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001190879.3"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": 11,
          "intron_rank_end": null,
          "gene_symbol": "ORC4",
          "gene_hgnc_id": 8490,
          "hgvs_c": "c.763-9_763-8insTTTTTTTTTTTTTTTTTTTTTTTTTTTT",
          "hgvs_p": null,
          "transcript": "NM_001374270.1",
          "protein_id": "NP_001361199.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 436,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1311,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001374270.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "ORC4",
          "gene_hgnc_id": 8490,
          "hgvs_c": "c.763-9_763-8insTTTTTTTTTTTTTTTTTTTTTTTTTTTT",
          "hgvs_p": null,
          "transcript": "NM_002552.5",
          "protein_id": "NP_002543.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 436,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1311,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_002552.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "ORC4",
          "gene_hgnc_id": 8490,
          "hgvs_c": "c.763-9_763-8insTTTTTTTTTTTTTTTTTTTTTTTTTTTT",
          "hgvs_p": null,
          "transcript": "NM_181742.4",
          "protein_id": "NP_859526.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 436,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1311,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_181742.4"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "ORC4",
          "gene_hgnc_id": 8490,
          "hgvs_c": "c.763-9_763-8insTTTTTTTTTTTTTTTTTTTTTTTTTTTT",
          "hgvs_p": null,
          "transcript": "ENST00000264169.6",
          "protein_id": "ENSP00000264169.2",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 436,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1311,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
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        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
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          "intron_rank": 10,
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          "gene_symbol": "ORC4",
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          "hgvs_c": "c.763-9_763-8insTTTTTTTTTTTTTTTTTTTTTTTTTTTT",
          "hgvs_p": null,
          "transcript": "ENST00000535373.5",
          "protein_id": "ENSP00000441953.1",
          "transcript_support_level": 5,
          "aa_start": null,
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          "cds_start": null,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
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          "aa_alt": null,
          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
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          "gene_symbol": "ORC4",
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          "hgvs_c": "c.763-9_763-8insTTTTTTTTTTTTTTTTTTTTTTTTTTTT",
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          "transcript": "ENST00000877929.1",
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        {
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          "canonical": false,
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          "strand": false,
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          "intron_rank": 10,
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          "gene_symbol": "ORC4",
          "gene_hgnc_id": 8490,
          "hgvs_c": "c.763-9_763-8insTTTTTTTTTTTTTTTTTTTTTTTTTTTT",
          "hgvs_p": null,
          "transcript": "ENST00000877930.1",
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        {
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        {
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        {
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