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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-173188491-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=173188491&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 173188491,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "NM_016653.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "NM_016653.3",
"protein_id": "NP_057737.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 800,
"cds_start": null,
"cds_end": null,
"cds_length": 2403,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000375213.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_016653.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000375213.8",
"protein_id": "ENSP00000364361.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 800,
"cds_start": null,
"cds_end": null,
"cds_length": 2403,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_016653.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000375213.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000409176.6",
"protein_id": "ENSP00000387259.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 800,
"cds_start": null,
"cds_end": null,
"cds_length": 2403,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000409176.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000338983.7",
"protein_id": "ENSP00000340257.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 455,
"cds_start": null,
"cds_end": null,
"cds_length": 1368,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000338983.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000539448.5",
"protein_id": "ENSP00000439414.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 455,
"cds_start": null,
"cds_end": null,
"cds_length": 1368,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000539448.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "n.584+868A>G",
"hgvs_p": null,
"transcript": "ENST00000476618.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000476618.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000893700.1",
"protein_id": "ENSP00000563759.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 800,
"cds_start": null,
"cds_end": null,
"cds_length": 2403,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893700.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000893705.1",
"protein_id": "ENSP00000563764.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 800,
"cds_start": null,
"cds_end": null,
"cds_length": 2403,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893705.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000893706.1",
"protein_id": "ENSP00000563765.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 800,
"cds_start": null,
"cds_end": null,
"cds_length": 2403,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893706.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000965866.1",
"protein_id": "ENSP00000635925.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 800,
"cds_start": null,
"cds_end": null,
"cds_length": 2403,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965866.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000965867.1",
"protein_id": "ENSP00000635926.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 800,
"cds_start": null,
"cds_end": null,
"cds_length": 2403,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965867.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000893703.1",
"protein_id": "ENSP00000563762.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 784,
"cds_start": null,
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"cds_length": 2355,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893703.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000965870.1",
"protein_id": "ENSP00000635929.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 779,
"cds_start": null,
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"cds_length": 2340,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965870.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
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"transcript": "ENST00000893701.1",
"protein_id": "ENSP00000563760.1",
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"biotype": "protein_coding",
"feature": "ENST00000893701.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000965869.1",
"protein_id": "ENSP00000635928.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965869.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
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"transcript": "ENST00000893704.1",
"protein_id": "ENSP00000563763.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000893704.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000965868.1",
"protein_id": "ENSP00000635927.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000965868.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "ENST00000893702.1",
"protein_id": "ENSP00000563761.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 743,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893702.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "NM_133646.3",
"protein_id": "NP_598407.1",
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"biotype": "protein_coding",
"feature": "NM_133646.3"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "XM_005246640.3",
"protein_id": "XP_005246697.1",
"transcript_support_level": null,
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"aa_end": null,
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"biotype": "protein_coding",
"feature": "XM_005246640.3"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "XM_047444746.1",
"protein_id": "XP_047300702.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 800,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047444746.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAP3K20",
"gene_hgnc_id": 17797,
"hgvs_c": "c.415+868A>G",
"hgvs_p": null,
"transcript": "XM_047444747.1",
"protein_id": "XP_047300703.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 800,
"cds_start": null,
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"cds_length": 2403,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047444747.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
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}
],
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}