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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-199348734-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=199348734&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 199348734,
"ref": "A",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_015265.4",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "NM_001172509.2",
"protein_id": "NP_001165980.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000417098.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001172509.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000417098.6",
"protein_id": "ENSP00000401112.1",
"transcript_support_level": 2,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001172509.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000417098.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000260926.9",
"protein_id": "ENSP00000260926.5",
"transcript_support_level": 1,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000260926.9"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.786T>A",
"hgvs_p": "p.Ala262Ala",
"transcript": "ENST00000428695.6",
"protein_id": "ENSP00000388581.1",
"transcript_support_level": 1,
"aa_start": 262,
"aa_end": null,
"aa_length": 615,
"cds_start": 786,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000428695.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "NM_001172517.1",
"protein_id": "NP_001165988.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001172517.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "NM_015265.4",
"protein_id": "NP_056080.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015265.4"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000457245.5",
"protein_id": "ENSP00000405420.1",
"transcript_support_level": 2,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000457245.5"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000700193.1",
"protein_id": "ENSP00000514854.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000700193.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000908772.1",
"protein_id": "ENSP00000578831.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000908772.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000908773.1",
"protein_id": "ENSP00000578832.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000908773.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000908774.1",
"protein_id": "ENSP00000578833.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000908774.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000908775.1",
"protein_id": "ENSP00000578834.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000908775.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000908777.1",
"protein_id": "ENSP00000578836.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000908777.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000908778.1",
"protein_id": "ENSP00000578837.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000908778.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000908779.1",
"protein_id": "ENSP00000578838.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000908779.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000908780.1",
"protein_id": "ENSP00000578839.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000908780.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000908781.1",
"protein_id": "ENSP00000578840.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000908781.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000908782.1",
"protein_id": "ENSP00000578841.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000908782.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000930191.1",
"protein_id": "ENSP00000600250.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930191.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000930192.1",
"protein_id": "ENSP00000600251.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930192.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000962920.1",
"protein_id": "ENSP00000632979.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962920.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SATB2",
"gene_hgnc_id": 21637,
"hgvs_c": "c.1140T>A",
"hgvs_p": "p.Ala380Ala",
"transcript": "ENST00000962921.1",
"protein_id": "ENSP00000632980.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 733,
"cds_start": 1140,
"cds_end": null,
"cds_length": 2202,
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"pathogenicity_classification_combined": "Benign",
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}
],
"message": null
}