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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-217812863-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=217812863&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 217812863,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000682258.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "TNS1",
"gene_hgnc_id": 11973,
"hgvs_c": "c.4954+352C>T",
"hgvs_p": null,
"transcript": "NM_001387777.1",
"protein_id": "NP_001374706.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1839,
"cds_start": -4,
"cds_end": null,
"cds_length": 5520,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10311,
"mane_select": "ENST00000682258.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "TNS1",
"gene_hgnc_id": 11973,
"hgvs_c": "c.4954+352C>T",
"hgvs_p": null,
"transcript": "ENST00000682258.1",
"protein_id": "ENSP00000506917.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1839,
"cds_start": -4,
"cds_end": null,
"cds_length": 5520,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10311,
"mane_select": "NM_001387777.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "TNS1",
"gene_hgnc_id": 11973,
"hgvs_c": "c.4642+352C>T",
"hgvs_p": null,
"transcript": "ENST00000171887.8",
"protein_id": "ENSP00000171887.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1735,
"cds_start": -4,
"cds_end": null,
"cds_length": 5208,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10331,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "TNS1",
"gene_hgnc_id": 11973,
"hgvs_c": "c.4600+352C>T",
"hgvs_p": null,
"transcript": "ENST00000419504.6",
"protein_id": "ENSP00000408724.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1721,
"cds_start": -4,
"cds_end": null,
"cds_length": 5166,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6154,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "TNS1",
"gene_hgnc_id": 11973,
"hgvs_c": "c.1975+352C>T",
"hgvs_p": null,
"transcript": "ENST00000446688.5",
"protein_id": "ENSP00000394171.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 846,
"cds_start": -4,
"cds_end": null,
"cds_length": 2541,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4292,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "TNS1",
"gene_hgnc_id": 11973,
"hgvs_c": "c.5017+352C>T",
"hgvs_p": null,
"transcript": "NM_001438865.1",
"protein_id": "NP_001425794.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1860,
"cds_start": -4,
"cds_end": null,
"cds_length": 5583,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10331,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "TNS1",
"gene_hgnc_id": 11973,
"hgvs_c": "c.5017+352C>T",
"hgvs_p": null,
"transcript": "ENST00000646520.1",
"protein_id": "ENSP00000493967.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1860,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 10680,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "TNS1",
"gene_hgnc_id": 11973,
"hgvs_c": "c.4951+352C>T",
"hgvs_p": null,
"transcript": "NM_001438866.1",
"protein_id": "NP_001425795.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1838,
"cds_start": -4,
"cds_end": null,
"cds_length": 5517,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10308,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "TNS1",
"gene_hgnc_id": 11973,
"hgvs_c": "c.4918+352C>T",
"hgvs_p": null,
"transcript": "ENST00000651849.1",
"protein_id": "ENSP00000498399.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1827,
"cds_start": -4,
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"cds_length": 5484,
"cdna_start": null,
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"mane_select": null,
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 31,
"intron_rank": 25,
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"gene_symbol": "TNS1",
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"hgvs_c": "c.4774+352C>T",
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"transcript": "NM_001438867.1",
"protein_id": "NP_001425796.1",
"transcript_support_level": null,
"aa_start": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"gene_symbol": "TNS1",
"gene_hgnc_id": 11973,
"hgvs_c": "c.4729+352C>T",
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"transcript": "ENST00000705226.1",
"protein_id": "ENSP00000516092.1",
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},
{
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],
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},
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],
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},
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],
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"gene_symbol": "TNS1",
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},
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],
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},
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"transcript": "ENST00000490566.1",
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],
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"gene_symbol": "TNS1",
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"transcript": "XM_024453078.2",
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},
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],
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