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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-9522081-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=9522081&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 9522081,
"ref": "G",
"alt": "T",
"effect": "non_coding_transcript_exon_variant",
"transcript": "ENST00000618923.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "n.*434C>A",
"hgvs_p": null,
"transcript": "ENST00000618923.2",
"protein_id": "ENSP00000480552.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1883,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "n.*434C>A",
"hgvs_p": null,
"transcript": "ENST00000618923.2",
"protein_id": "ENSP00000480552.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1883,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "c.844-765C>A",
"hgvs_p": null,
"transcript": "NM_003183.6",
"protein_id": "NP_003174.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 824,
"cds_start": -4,
"cds_end": null,
"cds_length": 2475,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4391,
"mane_select": "ENST00000310823.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "c.844-765C>A",
"hgvs_p": null,
"transcript": "ENST00000310823.8",
"protein_id": "ENSP00000309968.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 824,
"cds_start": -4,
"cds_end": null,
"cds_length": 2475,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4391,
"mane_select": "NM_003183.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "n.*343C>A",
"hgvs_p": null,
"transcript": "ENST00000647622.1",
"protein_id": "ENSP00000514299.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5715,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "n.2190C>A",
"hgvs_p": null,
"transcript": "ENST00000649068.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4740,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "n.2269C>A",
"hgvs_p": null,
"transcript": "ENST00000649972.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6573,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "n.*1392C>A",
"hgvs_p": null,
"transcript": "ENST00000699317.1",
"protein_id": "ENSP00000514296.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5558,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "n.2317C>A",
"hgvs_p": null,
"transcript": "ENST00000699319.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5622,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "n.*343C>A",
"hgvs_p": null,
"transcript": "ENST00000647622.1",
"protein_id": "ENSP00000514299.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5715,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "n.*1392C>A",
"hgvs_p": null,
"transcript": "ENST00000699317.1",
"protein_id": "ENSP00000514296.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5558,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "c.754-765C>A",
"hgvs_p": null,
"transcript": "ENST00000699318.1",
"protein_id": "ENSP00000514297.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 794,
"cds_start": -4,
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"cds_length": 2385,
"cdna_start": null,
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"cdna_length": 3528,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "c.184-765C>A",
"hgvs_p": null,
"transcript": "NM_001382777.1",
"protein_id": "NP_001369706.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 604,
"cds_start": -4,
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"cds_length": 1815,
"cdna_start": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "c.844-765C>A",
"hgvs_p": null,
"transcript": "ENST00000699324.1",
"protein_id": "ENSP00000514300.1",
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"cds_start": -4,
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},
{
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"strand": false,
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],
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"exon_count": 14,
"intron_rank": 7,
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"gene_symbol": "ADAM17",
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"hgvs_c": "c.844-765C>A",
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"transcript": "ENST00000699325.1",
"protein_id": "ENSP00000514301.1",
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "c.-59-760C>A",
"hgvs_p": null,
"transcript": "NM_001382778.1",
"protein_id": "NP_001369707.1",
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},
{
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],
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"intron_rank": 3,
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"gene_symbol": "ADAM17",
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"hgvs_c": "n.*304-765C>A",
"hgvs_p": null,
"transcript": "ENST00000647610.1",
"protein_id": "ENSP00000497929.1",
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "n.*374-765C>A",
"hgvs_p": null,
"transcript": "ENST00000647979.1",
"protein_id": "ENSP00000497542.1",
"transcript_support_level": null,
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"mane_select": null,
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"biotype": null,
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},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 20,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
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"hgvs_c": "n.1071-765C>A",
"hgvs_p": null,
"transcript": "ENST00000648548.1",
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},
{
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],
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"gene_symbol": "ADAM17",
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},
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 7,
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"gene_symbol": "ADAM17",
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"hgvs_c": "n.*605-765C>A",
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},
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"strand": false,
"consequences": [
"intron_variant"
],
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"exon_count": 15,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "n.654-765C>A",
"hgvs_p": null,
"transcript": "ENST00000649686.1",
"protein_id": null,
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"aa_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAM17",
"gene_hgnc_id": 195,
"hgvs_c": "n.*625-765C>A",
"hgvs_p": null,
"transcript": "ENST00000650116.1",
"protein_id": "ENSP00000497592.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"mane_select": null,
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"biotype": null,
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},
{
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"canonical": false,
"protein_coding": false,
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}
],
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}