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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-99831464-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=99831464&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 99831464,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000672756.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "AFF3",
"gene_hgnc_id": 6473,
"hgvs_c": "c.921+6013A>G",
"hgvs_p": null,
"transcript": "NM_001386135.1",
"protein_id": "NP_001373064.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1226,
"cds_start": -4,
"cds_end": null,
"cds_length": 3681,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10070,
"mane_select": "ENST00000672756.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "AFF3",
"gene_hgnc_id": 6473,
"hgvs_c": "c.921+6013A>G",
"hgvs_p": null,
"transcript": "ENST00000672756.2",
"protein_id": "ENSP00000500419.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1226,
"cds_start": -4,
"cds_end": null,
"cds_length": 3681,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10070,
"mane_select": "NM_001386135.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "AFF3",
"gene_hgnc_id": 6473,
"hgvs_c": "c.996+6013A>G",
"hgvs_p": null,
"transcript": "NM_001025108.2",
"protein_id": "NP_001020279.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1251,
"cds_start": -4,
"cds_end": null,
"cds_length": 3756,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9955,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "AFF3",
"gene_hgnc_id": 6473,
"hgvs_c": "c.996+6013A>G",
"hgvs_p": null,
"transcript": "ENST00000409579.5",
"protein_id": "ENSP00000386834.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1251,
"cds_start": -4,
"cds_end": null,
"cds_length": 3756,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4342,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "AFF3",
"gene_hgnc_id": 6473,
"hgvs_c": "c.921+6013A>G",
"hgvs_p": null,
"transcript": "NM_002285.3",
"protein_id": "NP_002276.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1226,
"cds_start": -4,
"cds_end": null,
"cds_length": 3681,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9987,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "AFF3",
"gene_hgnc_id": 6473,
"hgvs_c": "c.921+6013A>G",
"hgvs_p": null,
"transcript": "ENST00000317233.8",
"protein_id": "ENSP00000317421.4",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1226,
"cds_start": -4,
"cds_end": null,
"cds_length": 3681,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8135,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "AFF3",
"gene_hgnc_id": 6473,
"hgvs_c": "c.921+6013A>G",
"hgvs_p": null,
"transcript": "ENST00000409236.6",
"protein_id": "ENSP00000387207.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1226,
"cds_start": -4,
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"cds_length": 3681,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9849,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "AFF3",
"gene_hgnc_id": 6473,
"hgvs_c": "c.921+6013A>G",
"hgvs_p": null,
"transcript": "ENST00000672204.1",
"protein_id": "ENSP00000500616.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 607,
"cds_start": -4,
"cds_end": null,
"cds_length": 1824,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2060,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "AFF3",
"gene_hgnc_id": 6473,
"hgvs_c": "n.261+6013A>G",
"hgvs_p": null,
"transcript": "ENST00000430789.1",
"protein_id": "ENSP00000414099.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 730,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "AFF3",
"gene_hgnc_id": 6473,
"hgvs_c": "n.996+6013A>G",
"hgvs_p": null,
"transcript": "ENST00000672269.1",
"protein_id": "ENSP00000500310.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 3,
"intron_rank": 2,
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"gene_symbol": "AFF3",
"gene_hgnc_id": 6473,
"hgvs_c": "n.193-5528A>G",
"hgvs_p": null,
"transcript": "ENST00000673529.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 3,
"intron_rank": 1,
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"gene_symbol": "ENSG00000299017",
"gene_hgnc_id": null,
"hgvs_c": "n.42-766T>C",
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"transcript": "ENST00000759875.1",
"protein_id": null,
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},
{
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"strand": false,
"consequences": [
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],
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"exon_count": 25,
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"gene_symbol": "AFF3",
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"hgvs_c": "c.1383+6013A>G",
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"transcript": "XM_024452883.2",
"protein_id": "XP_024308651.1",
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},
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],
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"gene_symbol": "AFF3",
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"hgvs_c": "c.1383+6013A>G",
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},
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],
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"gene_symbol": "AFF3",
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"transcript": "XM_011511171.4",
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},
{
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],
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"exon_count": 24,
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"gene_symbol": "AFF3",
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"hgvs_c": "c.1308+6013A>G",
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],
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"gene_symbol": "AFF3",
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"hgvs_c": "c.1308+6013A>G",
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},
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],
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"exon_count": 28,
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"gene_symbol": "AFF3",
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"hgvs_c": "c.1191+6013A>G",
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"transcript": "XM_047444279.1",
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},
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],
"exon_rank": null,
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"gene_symbol": "AFF3",
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],
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},
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"strand": false,
"consequences": [
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],
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"intron_rank": 9,
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"gene_symbol": "AFF3",
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"hgvs_c": "c.996+6013A>G",
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"transcript": "XM_047444281.1",
"protein_id": "XP_047300237.1",
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},
{
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"consequences": [
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],
"exon_rank": null,
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"exon_count": 24,
"intron_rank": 7,
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"gene_symbol": "AFF3",
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"hgvs_c": "c.996+6013A>G",
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"transcript": "XM_047444282.1",
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}
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}