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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-45894040-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=45894040&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 45894040,
"ref": "T",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000646241.3",
"consequences": [
{
"aa_ref": "Y",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.745T>A",
"hgvs_p": "p.Tyr249Asn",
"transcript": "NM_000308.4",
"protein_id": "NP_000299.3",
"transcript_support_level": null,
"aa_start": 249,
"aa_end": null,
"aa_length": 480,
"cds_start": 745,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 790,
"cdna_end": null,
"cdna_length": 1858,
"mane_select": "ENST00000646241.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "N",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.745T>A",
"hgvs_p": "p.Tyr249Asn",
"transcript": "ENST00000646241.3",
"protein_id": "ENSP00000493613.2",
"transcript_support_level": null,
"aa_start": 249,
"aa_end": null,
"aa_length": 480,
"cds_start": 745,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 790,
"cdna_end": null,
"cdna_length": 1858,
"mane_select": "NM_000308.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.799T>A",
"hgvs_p": "p.Tyr267Asn",
"transcript": "ENST00000372484.8",
"protein_id": "ENSP00000361562.3",
"transcript_support_level": 1,
"aa_start": 267,
"aa_end": null,
"aa_length": 498,
"cds_start": 799,
"cds_end": null,
"cds_length": 1497,
"cdna_start": 1871,
"cdna_end": null,
"cdna_length": 2939,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.745T>A",
"hgvs_p": "p.Tyr249Asn",
"transcript": "ENST00000191018.9",
"protein_id": "ENSP00000191018.5",
"transcript_support_level": 1,
"aa_start": 249,
"aa_end": null,
"aa_length": 480,
"cds_start": 745,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 830,
"cdna_end": null,
"cdna_length": 1898,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.745T>A",
"hgvs_p": "p.Tyr249Asn",
"transcript": "ENST00000372459.7",
"protein_id": "ENSP00000361537.2",
"transcript_support_level": 1,
"aa_start": 249,
"aa_end": null,
"aa_length": 480,
"cds_start": 745,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 928,
"cdna_end": null,
"cdna_length": 1996,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.795T>A",
"hgvs_p": null,
"transcript": "ENST00000484855.4",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4697,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.799T>A",
"hgvs_p": "p.Tyr267Asn",
"transcript": "ENST00000677394.1",
"protein_id": "ENSP00000504790.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 498,
"cds_start": 799,
"cds_end": null,
"cds_length": 1497,
"cdna_start": 1725,
"cdna_end": null,
"cdna_length": 2774,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.745T>A",
"hgvs_p": "p.Tyr249Asn",
"transcript": "NM_001127695.3",
"protein_id": "NP_001121167.1",
"transcript_support_level": null,
"aa_start": 249,
"aa_end": null,
"aa_length": 480,
"cds_start": 745,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 836,
"cdna_end": null,
"cdna_length": 1904,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.745T>A",
"hgvs_p": "p.Tyr249Asn",
"transcript": "ENST00000607482.6",
"protein_id": "ENSP00000475524.2",
"transcript_support_level": 3,
"aa_start": 249,
"aa_end": null,
"aa_length": 480,
"cds_start": 745,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 819,
"cdna_end": null,
"cdna_length": 1887,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.694T>A",
"hgvs_p": "p.Tyr232Asn",
"transcript": "NM_001167594.3",
"protein_id": "NP_001161066.2",
"transcript_support_level": null,
"aa_start": 232,
"aa_end": null,
"aa_length": 463,
"cds_start": 694,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 739,
"cdna_end": null,
"cdna_length": 1807,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.694T>A",
"hgvs_p": "p.Tyr232Asn",
"transcript": "ENST00000354880.9",
"protein_id": "ENSP00000346952.5",
"transcript_support_level": 2,
"aa_start": 232,
"aa_end": null,
"aa_length": 463,
"cds_start": 694,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 752,
"cdna_end": null,
"cdna_length": 1820,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.745T>A",
"hgvs_p": "p.Tyr249Asn",
"transcript": "ENST00000678443.1",
"protein_id": "ENSP00000504006.1",
"transcript_support_level": null,
"aa_start": 249,
"aa_end": null,
"aa_length": 450,
"cds_start": 745,
"cds_end": null,
"cds_length": 1353,
"cdna_start": 745,
"cdna_end": null,
"cdna_length": 1697,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.745T>A",
"hgvs_p": "p.Tyr249Asn",
"transcript": "ENST00000419493.3",
"protein_id": "ENSP00000408533.3",
"transcript_support_level": 2,
"aa_start": 249,
"aa_end": null,
"aa_length": 392,
"cds_start": 745,
"cds_end": null,
"cds_length": 1179,
"cdna_start": 771,
"cdna_end": null,
"cdna_length": 1778,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.2177T>A",
"hgvs_p": null,
"transcript": "ENST00000480961.3",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.406T>A",
"hgvs_p": null,
"transcript": "ENST00000485627.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 695,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.1112T>A",
"hgvs_p": null,
"transcript": "ENST00000493522.8",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.1236T>A",
"hgvs_p": null,
"transcript": "ENST00000606066.3",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cds_length": null,
"cdna_start": null,
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"cdna_length": 2433,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.*387T>A",
"hgvs_p": null,
"transcript": "ENST00000606394.6",
"protein_id": "ENSP00000475827.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 992,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.866T>A",
"hgvs_p": null,
"transcript": "ENST00000606782.3",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
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"aa_length": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.*110T>A",
"hgvs_p": null,
"transcript": "ENST00000606788.5",
"protein_id": "ENSP00000476235.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.1162T>A",
"hgvs_p": null,
"transcript": "ENST00000607187.3",
"protein_id": null,
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"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.956T>A",
"hgvs_p": null,
"transcript": "ENST00000607212.3",
"protein_id": null,
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2153,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.2496T>A",
"hgvs_p": null,
"transcript": "ENST00000607814.7",
"protein_id": null,
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
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"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
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"exon_count": 15,
"intron_rank": null,
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"gene_symbol": "CTSA",
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"hgvs_c": "n.*568T>A",
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"transcript": "ENST00000677525.1",
"protein_id": "ENSP00000504197.1",
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"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1932,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
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"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.*300T>A",
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"transcript": "ENST00000678025.1",
"protein_id": "ENSP00000503463.1",
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"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2528,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.*110T>A",
"hgvs_p": null,
"transcript": "ENST00000678078.1",
"protein_id": "ENSP00000502993.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2278,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
}
],
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"dbsnp": "rs137854544",
"frequency_reference_population": 0.000045876222,
"hom_count_reference_population": 0,
"allele_count_reference_population": 74,
"gnomad_exomes_af": 0.0000444957,
"gnomad_genomes_af": 0.000059125,
"gnomad_exomes_ac": 65,
"gnomad_genomes_ac": 9,
"gnomad_exomes_homalt": 0,
"gnomad_genomes_homalt": 0,
"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": 0.6819995641708374,
"computational_prediction_selected": "Uncertain_significance",
"computational_source_selected": "MetaRNN",
"splice_score_selected": 0.07000000029802322,
"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
"revel_score": 0.458,
"revel_prediction": "Uncertain_significance",
"alphamissense_score": 0.2597,
"alphamissense_prediction": null,
"bayesdelnoaf_score": -0.14,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": 1.744,
"phylop100way_prediction": "Benign",
"spliceai_max_score": 0.07,
"spliceai_max_prediction": "Benign",
"dbscsnv_ada_score": null,
"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
"mitotip_prediction": null,
"acmg_score": 10,
"acmg_classification": "Pathogenic",
"acmg_criteria": "PM2,PP5_Very_Strong",
"acmg_by_gene": [
{
"score": 10,
"benign_score": 0,
"pathogenic_score": 10,
"criteria": [
"PM2",
"PP5_Very_Strong"
],
"verdict": "Pathogenic",
"transcript": "ENST00000646241.3",
"gene_symbol": "CTSA",
"hgnc_id": 9251,
"effects": [
"missense_variant"
],
"inheritance_mode": "AR",
"hgvs_c": "c.745T>A",
"hgvs_p": "p.Tyr249Asn"
}
],
"clinvar_disease": " late infantile,Combined deficiency of sialidase AND beta galactosidase,Galactosialidosis",
"clinvar_classification": "Pathogenic",
"clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
"clinvar_submissions_summary": "P:4",
"phenotype_combined": "Combined deficiency of sialidase AND beta galactosidase|Galactosialidosis, late infantile",
"pathogenicity_classification_combined": "Pathogenic",
"custom_annotations": null
}
],
"message": null
}