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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 21-14967968-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=21&pos=14967968&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "21",
"pos": 14967968,
"ref": "C",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "ENST00000318948.7",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_003489.4",
"protein_id": "NP_003480.2",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1018,
"cdna_end": null,
"cdna_length": 7751,
"mane_select": "ENST00000318948.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "ENST00000318948.7",
"protein_id": "ENSP00000327213.4",
"transcript_support_level": 2,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1018,
"cdna_end": null,
"cdna_length": 7751,
"mane_select": "NM_003489.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_001439275.1",
"protein_id": "NP_001426204.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1408,
"cdna_end": null,
"cdna_length": 8141,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_001439276.1",
"protein_id": "NP_001426205.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 957,
"cdna_end": null,
"cdna_length": 7690,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_001439277.1",
"protein_id": "NP_001426206.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1080,
"cdna_end": null,
"cdna_length": 7813,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_001439278.1",
"protein_id": "NP_001426207.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 851,
"cdna_end": null,
"cdna_length": 7584,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_001439279.1",
"protein_id": "NP_001426208.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 974,
"cdna_end": null,
"cdna_length": 7707,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_001439280.1",
"protein_id": "NP_001426209.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1001,
"cdna_end": null,
"cdna_length": 7734,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_001439281.1",
"protein_id": "NP_001426210.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1072,
"cdna_end": null,
"cdna_length": 7805,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_001439282.1",
"protein_id": "NP_001426211.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1124,
"cdna_end": null,
"cdna_length": 7857,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_001439283.1",
"protein_id": "NP_001426212.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1575,
"cdna_end": null,
"cdna_length": 8308,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_001439284.1",
"protein_id": "NP_001426213.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 815,
"cdna_end": null,
"cdna_length": 7548,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_001439285.1",
"protein_id": "NP_001426214.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 895,
"cdna_end": null,
"cdna_length": 7628,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_001439286.1",
"protein_id": "NP_001426215.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1393,
"cdna_end": null,
"cdna_length": 8126,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "NM_001439288.1",
"protein_id": "NP_001426217.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1104,
"cdna_end": null,
"cdna_length": 7837,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "ENST00000400199.5",
"protein_id": "ENSP00000383060.1",
"transcript_support_level": 3,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 829,
"cdna_end": null,
"cdna_length": 7562,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "ENST00000400202.5",
"protein_id": "ENSP00000383063.1",
"transcript_support_level": 5,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 938,
"cdna_end": null,
"cdna_length": 7671,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "XM_011529751.3",
"protein_id": "XP_011528053.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1099,
"cdna_end": null,
"cdna_length": 7832,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "XM_017028475.2",
"protein_id": "XP_016883964.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
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"cdna_start": 1531,
"cdna_end": null,
"cdna_length": 8264,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "XM_047440991.1",
"protein_id": "XP_047296947.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1088,
"cdna_end": null,
"cdna_length": 7821,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "XM_047440992.1",
"protein_id": "XP_047296948.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1044,
"cdna_end": null,
"cdna_length": 7777,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "XM_047440993.1",
"protein_id": "XP_047296949.1",
"transcript_support_level": null,
"aa_start": 75,
"aa_end": null,
"aa_length": 1158,
"cds_start": 225,
"cds_end": null,
"cds_length": 3477,
"cdna_start": 1153,
"cdna_end": null,
"cdna_length": 7886,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRIP1",
"gene_hgnc_id": 8001,
"hgvs_c": "c.225G>C",
"hgvs_p": "p.Gly75Gly",
"transcript": "XM_047440994.1",
"protein_id": "XP_047296950.1",
"transcript_support_level": null,
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],
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{
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],
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}
],
"message": null
}