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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 21-31706612-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=21&pos=31706612&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "21",
"pos": 31706612,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "NM_020706.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "NM_020706.2",
"protein_id": "NP_065757.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1147,
"cds_start": null,
"cds_end": null,
"cds_length": 3444,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000286835.12",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_020706.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "ENST00000286835.12",
"protein_id": "ENSP00000286835.7",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1147,
"cds_start": null,
"cds_end": null,
"cds_length": 3444,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_020706.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000286835.12"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "ENST00000434667.3",
"protein_id": "ENSP00000402377.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1132,
"cds_start": null,
"cds_end": null,
"cds_length": 3399,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000434667.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "ENST00000399804.5",
"protein_id": "ENSP00000382703.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1125,
"cds_start": null,
"cds_end": null,
"cds_length": 3378,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000399804.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "ENST00000908758.1",
"protein_id": "ENSP00000578817.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1146,
"cds_start": null,
"cds_end": null,
"cds_length": 3441,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000908758.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "ENST00000908762.1",
"protein_id": "ENSP00000578821.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1145,
"cds_start": null,
"cds_end": null,
"cds_length": 3438,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000908762.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "ENST00000931674.1",
"protein_id": "ENSP00000601733.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1144,
"cds_start": null,
"cds_end": null,
"cds_length": 3435,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931674.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "ENST00000908761.1",
"protein_id": "ENSP00000578820.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1143,
"cds_start": null,
"cds_end": null,
"cds_length": 3432,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000908761.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "ENST00000949917.1",
"protein_id": "ENSP00000619976.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1141,
"cds_start": null,
"cds_end": null,
"cds_length": 3426,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949917.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "NM_001145444.1",
"protein_id": "NP_001138916.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1132,
"cds_start": null,
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"cds_length": 3399,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001145444.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
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"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "NM_001145445.1",
"protein_id": "NP_001138917.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1125,
"cds_start": null,
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"cds_length": 3378,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001145445.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 20,
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"gene_symbol": "SCAF4",
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"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "ENST00000908760.1",
"protein_id": "ENSP00000578819.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000908760.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 20,
"intron_rank": 1,
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"gene_symbol": "SCAF4",
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"hgvs_c": "c.31-255C>T",
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"transcript": "ENST00000908759.1",
"protein_id": "ENSP00000578818.1",
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"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000908759.1"
},
{
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"strand": false,
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],
"exon_rank": null,
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"gene_symbol": "SCAF4",
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"hgvs_c": "c.31-255C>T",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "ENST00000931675.1",
"protein_id": "ENSP00000601734.1",
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000931675.1"
},
{
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"strand": false,
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],
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"intron_rank": 1,
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"gene_symbol": "SCAF4",
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"transcript": "ENST00000908765.1",
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"biotype": "protein_coding",
"feature": "ENST00000908765.1"
},
{
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "ENST00000908757.1",
"protein_id": "ENSP00000578816.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000908757.1"
},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 1,
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"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "ENST00000908763.1",
"protein_id": "ENSP00000578822.1",
"transcript_support_level": null,
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},
{
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"strand": false,
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],
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"intron_rank": 1,
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"gene_symbol": "SCAF4",
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"hgvs_c": "c.31-255C>T",
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"transcript": "ENST00000908764.1",
"protein_id": "ENSP00000578823.1",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"gene_symbol": "SCAF4",
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"hgvs_c": "c.31-255C>T",
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"transcript": "ENST00000908755.1",
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},
{
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"consequences": [
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],
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"gene_symbol": "SCAF4",
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"hgvs_c": "c.31-9862C>T",
"hgvs_p": null,
"transcript": "ENST00000931676.1",
"protein_id": "ENSP00000601735.1",
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"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000931676.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SCAF4",
"gene_hgnc_id": 19304,
"hgvs_c": "c.31-255C>T",
"hgvs_p": null,
"transcript": "XM_006724035.4",
"protein_id": "XP_006724098.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1143,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006724035.4"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 20,
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}
],
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}