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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 21-33542291-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=21&pos=33542291&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "21",
"pos": 33542291,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "NM_001136005.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-9+296C>T",
"hgvs_p": null,
"transcript": "ENST00000381831.7",
"protein_id": "ENSP00000371253.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
"cds_end": null,
"cds_length": 3033,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000381831.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-42+369C>T",
"hgvs_p": null,
"transcript": "ENST00000381839.7",
"protein_id": "ENSP00000371261.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
"cds_end": null,
"cds_length": 3033,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000381839.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "n.-42+300C>T",
"hgvs_p": null,
"transcript": "ENST00000424203.5",
"protein_id": "ENSP00000390003.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000424203.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-235C>T",
"hgvs_p": null,
"transcript": "ENST00000441403.1",
"protein_id": "ENSP00000407783.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 135,
"cds_start": null,
"cds_end": null,
"cds_length": 408,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000441403.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-9+296C>T",
"hgvs_p": null,
"transcript": "NM_001136005.1",
"protein_id": "NP_001129477.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
"cds_end": null,
"cds_length": 3033,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001136005.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-42+369C>T",
"hgvs_p": null,
"transcript": "NM_001136006.1",
"protein_id": "NP_001129478.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
"cds_end": null,
"cds_length": 3033,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001136006.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-9+1132C>T",
"hgvs_p": null,
"transcript": "ENST00000880373.1",
"protein_id": "ENSP00000550432.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
"cds_end": null,
"cds_length": 3033,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000880373.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-42+257C>T",
"hgvs_p": null,
"transcript": "ENST00000880374.1",
"protein_id": "ENSP00000550433.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
"cds_end": null,
"cds_length": 3033,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000880374.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-42+296C>T",
"hgvs_p": null,
"transcript": "ENST00000880375.1",
"protein_id": "ENSP00000550434.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
"cds_end": null,
"cds_length": 3033,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000880375.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-42+300C>T",
"hgvs_p": null,
"transcript": "ENST00000880376.1",
"protein_id": "ENSP00000550435.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
"cds_end": null,
"cds_length": 3033,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000880376.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-42+359C>T",
"hgvs_p": null,
"transcript": "ENST00000880377.1",
"protein_id": "ENSP00000550436.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
"cds_end": null,
"cds_length": 3033,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000880377.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-42+369C>T",
"hgvs_p": null,
"transcript": "ENST00000880380.1",
"protein_id": "ENSP00000550439.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 964,
"cds_start": null,
"cds_end": null,
"cds_length": 2895,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000880380.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-42+257C>T",
"hgvs_p": null,
"transcript": "ENST00000962328.1",
"protein_id": "ENSP00000632387.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 964,
"cds_start": null,
"cds_end": null,
"cds_length": 2895,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962328.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-9+929C>T",
"hgvs_p": null,
"transcript": "ENST00000935277.1",
"protein_id": "ENSP00000605336.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 955,
"cds_start": null,
"cds_end": null,
"cds_length": 2868,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935277.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-42+929C>T",
"hgvs_p": null,
"transcript": "ENST00000430874.5",
"protein_id": "ENSP00000413040.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 240,
"cds_start": null,
"cds_end": null,
"cds_length": 723,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000430874.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-9+369C>T",
"hgvs_p": null,
"transcript": "ENST00000426819.5",
"protein_id": "ENSP00000398631.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 230,
"cds_start": null,
"cds_end": null,
"cds_length": 695,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000426819.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-9+257C>T",
"hgvs_p": null,
"transcript": "ENST00000438059.5",
"protein_id": "ENSP00000413803.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 137,
"cds_start": null,
"cds_end": null,
"cds_length": 416,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000438059.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-42+257C>T",
"hgvs_p": null,
"transcript": "XM_005260941.3",
"protein_id": "XP_005260998.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
"cds_end": null,
"cds_length": 3033,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005260941.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-9+257C>T",
"hgvs_p": null,
"transcript": "XM_006723989.3",
"protein_id": "XP_006724052.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
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"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006723989.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-9+369C>T",
"hgvs_p": null,
"transcript": "XM_006723990.3",
"protein_id": "XP_006724053.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
"cds_end": null,
"cds_length": 3033,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006723990.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-42+296C>T",
"hgvs_p": null,
"transcript": "XM_011529526.3",
"protein_id": "XP_011527828.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
"cds_end": null,
"cds_length": 3033,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011529526.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "GART",
"gene_hgnc_id": 4163,
"hgvs_c": "c.-9+560C>T",
"hgvs_p": null,
"transcript": "XM_047440743.1",
"protein_id": "XP_047296699.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1010,
"cds_start": null,
"cds_end": null,
"cds_length": 3033,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047440743.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
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