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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 21-45925731-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=21&pos=45925731&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "21",
"pos": 45925731,
"ref": "C",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000681687.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.718-4186C>A",
"hgvs_p": null,
"transcript": "NM_001384156.1",
"protein_id": "NP_001371085.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 371,
"cds_start": -4,
"cds_end": null,
"cds_length": 1116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2282,
"mane_select": "ENST00000681687.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.718-4186C>A",
"hgvs_p": null,
"transcript": "ENST00000681687.1",
"protein_id": "ENSP00000505796.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 371,
"cds_start": -4,
"cds_end": null,
"cds_length": 1116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2282,
"mane_select": "NM_001384156.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.691-4189C>A",
"hgvs_p": null,
"transcript": "ENST00000400304.1",
"protein_id": "ENSP00000383159.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 361,
"cds_start": -4,
"cds_end": null,
"cds_length": 1086,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1086,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.643-4189C>A",
"hgvs_p": null,
"transcript": "ENST00000400308.5",
"protein_id": "ENSP00000383163.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 345,
"cds_start": -4,
"cds_end": null,
"cds_length": 1038,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1911,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.787-4186C>A",
"hgvs_p": null,
"transcript": "NM_001348240.2",
"protein_id": "NP_001335169.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 394,
"cds_start": -4,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2272,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.787-4186C>A",
"hgvs_p": null,
"transcript": "NM_001382279.1",
"protein_id": "NP_001369208.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 394,
"cds_start": -4,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2306,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.787-4189C>A",
"hgvs_p": null,
"transcript": "NM_001348239.2",
"protein_id": "NP_001335168.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 393,
"cds_start": -4,
"cds_end": null,
"cds_length": 1182,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2348,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.751-4186C>A",
"hgvs_p": null,
"transcript": "NM_001348241.2",
"protein_id": "NP_001335170.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 382,
"cds_start": -4,
"cds_end": null,
"cds_length": 1149,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2315,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.787-4189C>A",
"hgvs_p": null,
"transcript": "NM_001348245.2",
"protein_id": "NP_001335174.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 373,
"cds_start": -4,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2243,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.718-4186C>A",
"hgvs_p": null,
"transcript": "NM_001382277.1",
"protein_id": "NP_001369206.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 371,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.718-4186C>A",
"hgvs_p": null,
"transcript": "NM_001382281.1",
"protein_id": "NP_001369210.1",
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"aa_start": null,
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"cds_start": -4,
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"feature": null
},
{
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"strand": true,
"consequences": [
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],
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"gene_symbol": "PCBP3",
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"hgvs_c": "c.718-4186C>A",
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"transcript": "NM_001382282.1",
"protein_id": "NP_001369211.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 12,
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"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.718-4186C>A",
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"transcript": "NM_001382283.1",
"protein_id": "NP_001369212.1",
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},
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"strand": true,
"consequences": [
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],
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"gene_symbol": "PCBP3",
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"hgvs_c": "c.718-4186C>A",
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"transcript": "NM_001382284.1",
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},
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],
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"transcript": "NM_001382285.1",
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},
{
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],
"exon_rank": null,
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"intron_rank": 12,
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"gene_symbol": "PCBP3",
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"hgvs_c": "c.718-4186C>A",
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},
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],
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"gene_symbol": "PCBP3",
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"hgvs_c": "c.718-4186C>A",
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"transcript": "NM_001382287.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.718-4186C>A",
"hgvs_p": null,
"transcript": "NM_001382288.1",
"protein_id": "NP_001369217.1",
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},
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],
"exon_rank": null,
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"exon_count": 15,
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"gene_symbol": "PCBP3",
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"hgvs_c": "c.718-4186C>A",
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"transcript": "NM_020528.3",
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],
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},
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],
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"gene_symbol": "PCBP3",
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"hgvs_c": "c.718-4189C>A",
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},
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.718-4189C>A",
"hgvs_p": null,
"transcript": "NM_001382278.1",
"protein_id": "NP_001369207.1",
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"aa_start": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "PCBP3",
"gene_hgnc_id": 8651,
"hgvs_c": "c.718-4189C>A",
"hgvs_p": null,
"transcript": "ENST00000400309.5",
"protein_id": "ENSP00000383164.1",
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"aa_start": null,
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}