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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 22-19201492-AC-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=19201492&ref=AC&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "22",
"pos": 19201492,
"ref": "AC",
"alt": "A",
"effect": "frameshift_variant,splice_region_variant",
"transcript": "NM_007098.4",
"consequences": [
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3601delG",
"hgvs_p": "p.Val1201fs",
"transcript": "NM_007098.4",
"protein_id": "NP_009029.3",
"transcript_support_level": null,
"aa_start": 1201,
"aa_end": null,
"aa_length": 1640,
"cds_start": 3601,
"cds_end": null,
"cds_length": 4923,
"cdna_start": 3679,
"cdna_end": null,
"cdna_length": 5518,
"mane_select": "ENST00000427926.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_007098.4"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3601delG",
"hgvs_p": "p.Val1201fs",
"transcript": "ENST00000427926.6",
"protein_id": "ENSP00000441158.1",
"transcript_support_level": 1,
"aa_start": 1201,
"aa_end": null,
"aa_length": 1640,
"cds_start": 3601,
"cds_end": null,
"cds_length": 4923,
"cdna_start": 3679,
"cdna_end": null,
"cdna_length": 5518,
"mane_select": "NM_007098.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000427926.6"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3601delG",
"hgvs_p": "p.Val1201fs",
"transcript": "ENST00000621271.4",
"protein_id": "ENSP00000485020.1",
"transcript_support_level": 1,
"aa_start": 1201,
"aa_end": null,
"aa_length": 1583,
"cds_start": 3601,
"cds_end": null,
"cds_length": 4752,
"cdna_start": 3645,
"cdna_end": null,
"cdna_length": 5313,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000621271.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"splice_region_variant",
"non_coding_transcript_exon_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "n.3621delG",
"hgvs_p": null,
"transcript": "ENST00000615606.4",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4994,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000615606.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"splice_region_variant",
"non_coding_transcript_exon_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "n.3601delG",
"hgvs_p": null,
"transcript": "ENST00000617103.4",
"protein_id": "ENSP00000480709.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4859,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000617103.4"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3601delG",
"hgvs_p": "p.Val1201fs",
"transcript": "ENST00000965499.1",
"protein_id": "ENSP00000635558.1",
"transcript_support_level": null,
"aa_start": 1201,
"aa_end": null,
"aa_length": 1640,
"cds_start": 3601,
"cds_end": null,
"cds_length": 4923,
"cdna_start": 3706,
"cdna_end": null,
"cdna_length": 5774,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965499.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3601delG",
"hgvs_p": "p.Val1201fs",
"transcript": "ENST00000897134.1",
"protein_id": "ENSP00000567193.1",
"transcript_support_level": null,
"aa_start": 1201,
"aa_end": null,
"aa_length": 1632,
"cds_start": 3601,
"cds_end": null,
"cds_length": 4899,
"cdna_start": 3645,
"cdna_end": null,
"cdna_length": 5460,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897134.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3601delG",
"hgvs_p": "p.Val1201fs",
"transcript": "ENST00000965503.1",
"protein_id": "ENSP00000635562.1",
"transcript_support_level": null,
"aa_start": 1201,
"aa_end": null,
"aa_length": 1620,
"cds_start": 3601,
"cds_end": null,
"cds_length": 4863,
"cdna_start": 3701,
"cdna_end": null,
"cdna_length": 5480,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965503.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3601delG",
"hgvs_p": "p.Val1201fs",
"transcript": "ENST00000965502.1",
"protein_id": "ENSP00000635561.1",
"transcript_support_level": null,
"aa_start": 1201,
"aa_end": null,
"aa_length": 1604,
"cds_start": 3601,
"cds_end": null,
"cds_length": 4815,
"cdna_start": 3708,
"cdna_end": null,
"cdna_length": 5434,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965502.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3487delG",
"hgvs_p": "p.Val1163fs",
"transcript": "ENST00000897132.1",
"protein_id": "ENSP00000567191.1",
"transcript_support_level": null,
"aa_start": 1163,
"aa_end": null,
"aa_length": 1602,
"cds_start": 3487,
"cds_end": null,
"cds_length": 4809,
"cdna_start": 3571,
"cdna_end": null,
"cdna_length": 5410,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897132.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3448delG",
"hgvs_p": "p.Val1150fs",
"transcript": "ENST00000932470.1",
"protein_id": "ENSP00000602529.1",
"transcript_support_level": null,
"aa_start": 1150,
"aa_end": null,
"aa_length": 1589,
"cds_start": 3448,
"cds_end": null,
"cds_length": 4770,
"cdna_start": 3503,
"cdna_end": null,
"cdna_length": 5342,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932470.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3601delG",
"hgvs_p": "p.Val1201fs",
"transcript": "ENST00000932468.1",
"protein_id": "ENSP00000602527.1",
"transcript_support_level": null,
"aa_start": 1201,
"aa_end": null,
"aa_length": 1584,
"cds_start": 3601,
"cds_end": null,
"cds_length": 4755,
"cdna_start": 3679,
"cdna_end": null,
"cdna_length": 5350,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932468.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3601delG",
"hgvs_p": "p.Val1201fs",
"transcript": "NM_001835.4",
"protein_id": "NP_001826.3",
"transcript_support_level": null,
"aa_start": 1201,
"aa_end": null,
"aa_length": 1583,
"cds_start": 3601,
"cds_end": null,
"cds_length": 4752,
"cdna_start": 3679,
"cdna_end": null,
"cdna_length": 5347,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001835.4"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3601delG",
"hgvs_p": "p.Val1201fs",
"transcript": "ENST00000965511.1",
"protein_id": "ENSP00000635570.1",
"transcript_support_level": null,
"aa_start": 1201,
"aa_end": null,
"aa_length": 1583,
"cds_start": 3601,
"cds_end": null,
"cds_length": 4752,
"cdna_start": 3679,
"cdna_end": null,
"cdna_length": 5576,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965511.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3427delG",
"hgvs_p": "p.Val1143fs",
"transcript": "ENST00000932469.1",
"protein_id": "ENSP00000602528.1",
"transcript_support_level": null,
"aa_start": 1143,
"aa_end": null,
"aa_length": 1582,
"cds_start": 3427,
"cds_end": null,
"cds_length": 4749,
"cdna_start": 3493,
"cdna_end": null,
"cdna_length": 5332,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932469.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3487delG",
"hgvs_p": "p.Val1163fs",
"transcript": "ENST00000965515.1",
"protein_id": "ENSP00000635574.1",
"transcript_support_level": null,
"aa_start": 1163,
"aa_end": null,
"aa_length": 1582,
"cds_start": 3487,
"cds_end": null,
"cds_length": 4749,
"cdna_start": 3561,
"cdna_end": null,
"cdna_length": 5337,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965515.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3601delG",
"hgvs_p": "p.Val1201fs",
"transcript": "ENST00000897133.1",
"protein_id": "ENSP00000567192.1",
"transcript_support_level": null,
"aa_start": 1201,
"aa_end": null,
"aa_length": 1575,
"cds_start": 3601,
"cds_end": null,
"cds_length": 4728,
"cdna_start": 3645,
"cdna_end": null,
"cdna_length": 5289,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897133.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3448delG",
"hgvs_p": "p.Val1150fs",
"transcript": "ENST00000965496.1",
"protein_id": "ENSP00000635555.1",
"transcript_support_level": null,
"aa_start": 1150,
"aa_end": null,
"aa_length": 1569,
"cds_start": 3448,
"cds_end": null,
"cds_length": 4710,
"cdna_start": 3579,
"cdna_end": null,
"cdna_length": 5358,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965496.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3601delG",
"hgvs_p": "p.Val1201fs",
"transcript": "ENST00000965495.1",
"protein_id": "ENSP00000635554.1",
"transcript_support_level": null,
"aa_start": 1201,
"aa_end": null,
"aa_length": 1546,
"cds_start": 3601,
"cds_end": null,
"cds_length": 4641,
"cdna_start": 3734,
"cdna_end": null,
"cdna_length": 5444,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965495.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3601delG",
"hgvs_p": "p.Val1201fs",
"transcript": "ENST00000965512.1",
"protein_id": "ENSP00000635571.1",
"transcript_support_level": null,
"aa_start": 1201,
"aa_end": null,
"aa_length": 1546,
"cds_start": 3601,
"cds_end": null,
"cds_length": 4641,
"cdna_start": 3678,
"cdna_end": null,
"cdna_length": 5233,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965512.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant",
"splice_region_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLTCL1",
"gene_hgnc_id": 2093,
"hgvs_c": "c.3487delG",
"hgvs_p": "p.Val1163fs",
"transcript": "ENST00000965501.1",
"protein_id": "ENSP00000635560.1",
"transcript_support_level": null,
"aa_start": 1163,
"aa_end": null,
"aa_length": 1545,
"cds_start": 3487,
"cds_end": null,
"cds_length": 4638,
"cdna_start": 3592,
"cdna_end": null,
"cdna_length": 5258,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965501.1"
},
{
"aa_ref": "V",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
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}
],
"message": null
}