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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 22-19967634-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=19967634&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "22",
"pos": 19967634,
"ref": "G",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000361682.11",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.616-902G>T",
"hgvs_p": null,
"transcript": "NM_000754.4",
"protein_id": "NP_000745.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 271,
"cds_start": -4,
"cds_end": null,
"cds_length": 816,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2272,
"mane_select": "ENST00000361682.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.616-902G>T",
"hgvs_p": null,
"transcript": "ENST00000361682.11",
"protein_id": "ENSP00000354511.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 271,
"cds_start": -4,
"cds_end": null,
"cds_length": 816,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2272,
"mane_select": "NM_000754.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.616-902G>T",
"hgvs_p": null,
"transcript": "ENST00000406520.7",
"protein_id": "ENSP00000385150.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 271,
"cds_start": -4,
"cds_end": null,
"cds_length": 816,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1339,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.466-902G>T",
"hgvs_p": null,
"transcript": "ENST00000449653.5",
"protein_id": "ENSP00000416778.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 221,
"cds_start": -4,
"cds_end": null,
"cds_length": 666,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1035,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.*207G>T",
"hgvs_p": null,
"transcript": "ENST00000428707.2",
"protein_id": "ENSP00000387695.2",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 292,
"cds_start": -4,
"cds_end": null,
"cds_length": 879,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2492,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.709-902G>T",
"hgvs_p": null,
"transcript": "ENST00000678769.1",
"protein_id": "ENSP00000503289.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 302,
"cds_start": -4,
"cds_end": null,
"cds_length": 909,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2202,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.616-902G>T",
"hgvs_p": null,
"transcript": "NM_001135161.2",
"protein_id": "NP_001128633.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 271,
"cds_start": -4,
"cds_end": null,
"cds_length": 816,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2297,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.616-902G>T",
"hgvs_p": null,
"transcript": "NM_001135162.2",
"protein_id": "NP_001128634.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 271,
"cds_start": -4,
"cds_end": null,
"cds_length": 816,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2283,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.616-902G>T",
"hgvs_p": null,
"transcript": "NM_001362828.2",
"protein_id": "NP_001349757.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 271,
"cds_start": -4,
"cds_end": null,
"cds_length": 816,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2566,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.616-902G>T",
"hgvs_p": null,
"transcript": "ENST00000403710.5",
"protein_id": "ENSP00000385917.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 271,
"cds_start": -4,
"cds_end": null,
"cds_length": 816,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1548,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.616-902G>T",
"hgvs_p": null,
"transcript": "ENST00000407537.5",
"protein_id": "ENSP00000384654.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 271,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 1457,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 5,
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"gene_symbol": "COMT",
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"hgvs_c": "c.616-902G>T",
"hgvs_p": null,
"transcript": "ENST00000676678.1",
"protein_id": "ENSP00000503719.1",
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"aa_start": null,
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"cdna_start": null,
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"feature": null
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 5,
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"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.616-902G>T",
"hgvs_p": null,
"transcript": "ENST00000678255.1",
"protein_id": "ENSP00000504402.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 6,
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"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.616-902G>T",
"hgvs_p": null,
"transcript": "ENST00000678868.1",
"protein_id": "ENSP00000503583.1",
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},
{
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],
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"gene_symbol": "COMT",
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"hgvs_c": "c.616-902G>T",
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"transcript": "ENST00000412786.5",
"protein_id": "ENSP00000403958.1",
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "c.466-902G>T",
"hgvs_p": null,
"transcript": "NM_007310.3",
"protein_id": "NP_009294.1",
"transcript_support_level": null,
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},
{
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],
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"intron_rank": 5,
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"gene_symbol": "COMT",
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"hgvs_c": "n.*74-902G>T",
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"transcript": "ENST00000207636.9",
"protein_id": "ENSP00000207636.5",
"transcript_support_level": 5,
"aa_start": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "n.*194+13G>T",
"hgvs_p": null,
"transcript": "ENST00000677397.1",
"protein_id": "ENSP00000503422.1",
"transcript_support_level": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "COMT",
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"hgvs_c": "n.466-902G>T",
"hgvs_p": null,
"transcript": "ENST00000677470.1",
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},
{
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"strand": true,
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],
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"intron_rank": 2,
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"gene_symbol": "COMT",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"gene_symbol": "COMT",
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"transcript": "ENST00000677675.1",
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 3,
"intron_rank": 2,
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"gene_symbol": "COMT",
"gene_hgnc_id": 2228,
"hgvs_c": "n.484-902G>T",
"hgvs_p": null,
"transcript": "ENST00000678945.1",
"protein_id": null,
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"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "ARVCF",
"gene_hgnc_id": 728,
"hgvs_c": "c.2782-425C>A",
"hgvs_p": null,
"transcript": "XM_006724243.4",
"protein_id": "XP_006724306.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1004,
"cds_start": -4,
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"cds_length": 3015,
"cdna_start": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
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{
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{
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}
],
"message": null
}