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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 22-46235156-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=46235156&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "22",
      "pos": 46235156,
      "ref": "G",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "ENST00000407236.6",
      "consequences": [
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPARA",
          "gene_hgnc_id": 9232,
          "hgvs_c": "c.1183G>C",
          "hgvs_p": "p.Gly395Arg",
          "transcript": "NM_005036.6",
          "protein_id": "NP_005027.2",
          "transcript_support_level": null,
          "aa_start": 395,
          "aa_end": null,
          "aa_length": 468,
          "cds_start": 1183,
          "cds_end": null,
          "cds_length": 1407,
          "cdna_start": 1519,
          "cdna_end": null,
          "cdna_length": 10118,
          "mane_select": "ENST00000407236.6",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPARA",
          "gene_hgnc_id": 9232,
          "hgvs_c": "c.1183G>C",
          "hgvs_p": "p.Gly395Arg",
          "transcript": "ENST00000407236.6",
          "protein_id": "ENSP00000385523.1",
          "transcript_support_level": 1,
          "aa_start": 395,
          "aa_end": null,
          "aa_length": 468,
          "cds_start": 1183,
          "cds_end": null,
          "cds_length": 1407,
          "cdna_start": 1519,
          "cdna_end": null,
          "cdna_length": 10118,
          "mane_select": "NM_005036.6",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPARA",
          "gene_hgnc_id": 9232,
          "hgvs_c": "c.1183G>C",
          "hgvs_p": "p.Gly395Arg",
          "transcript": "ENST00000402126.2",
          "protein_id": "ENSP00000385246.1",
          "transcript_support_level": 1,
          "aa_start": 395,
          "aa_end": null,
          "aa_length": 468,
          "cds_start": 1183,
          "cds_end": null,
          "cds_length": 1407,
          "cdna_start": 1319,
          "cdna_end": null,
          "cdna_length": 1566,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPARA",
          "gene_hgnc_id": 9232,
          "hgvs_c": "c.1183G>C",
          "hgvs_p": "p.Gly395Arg",
          "transcript": "NM_001001928.4",
          "protein_id": "NP_001001928.1",
          "transcript_support_level": null,
          "aa_start": 395,
          "aa_end": null,
          "aa_length": 468,
          "cds_start": 1183,
          "cds_end": null,
          "cds_length": 1407,
          "cdna_start": 1435,
          "cdna_end": null,
          "cdna_length": 10034,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPARA",
          "gene_hgnc_id": 9232,
          "hgvs_c": "c.1183G>C",
          "hgvs_p": "p.Gly395Arg",
          "transcript": "NM_001001929.3",
          "protein_id": "NP_001001929.1",
          "transcript_support_level": null,
          "aa_start": 395,
          "aa_end": null,
          "aa_length": 468,
          "cds_start": 1183,
          "cds_end": null,
          "cds_length": 1407,
          "cdna_start": 1434,
          "cdna_end": null,
          "cdna_length": 10034,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPARA",
          "gene_hgnc_id": 9232,
          "hgvs_c": "c.1183G>C",
          "hgvs_p": "p.Gly395Arg",
          "transcript": "NM_001362872.2",
          "protein_id": "NP_001349801.1",
          "transcript_support_level": null,
          "aa_start": 395,
          "aa_end": null,
          "aa_length": 468,
          "cds_start": 1183,
          "cds_end": null,
          "cds_length": 1407,
          "cdna_start": 1516,
          "cdna_end": null,
          "cdna_length": 10115,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPARA",
          "gene_hgnc_id": 9232,
          "hgvs_c": "c.1183G>C",
          "hgvs_p": "p.Gly395Arg",
          "transcript": "NM_001362873.3",
          "protein_id": "NP_001349802.1",
          "transcript_support_level": null,
          "aa_start": 395,
          "aa_end": null,
          "aa_length": 468,
          "cds_start": 1183,
          "cds_end": null,
          "cds_length": 1407,
          "cdna_start": 1782,
          "cdna_end": null,
          "cdna_length": 10381,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPARA",
          "gene_hgnc_id": 9232,
          "hgvs_c": "c.1183G>C",
          "hgvs_p": "p.Gly395Arg",
          "transcript": "NM_001393941.1",
          "protein_id": "NP_001380870.1",
          "transcript_support_level": null,
          "aa_start": 395,
          "aa_end": null,
          "aa_length": 468,
          "cds_start": 1183,
          "cds_end": null,
          "cds_length": 1407,
          "cdna_start": 1432,
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          "cdna_length": 10031,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPARA",
          "gene_hgnc_id": 9232,
          "hgvs_c": "c.1183G>C",
          "hgvs_p": "p.Gly395Arg",
          "transcript": "NM_001393942.1",
          "protein_id": "NP_001380871.1",
          "transcript_support_level": null,
          "aa_start": 395,
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          "cds_start": 1183,
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          "mane_select": null,
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        },
        {
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          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 9,
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          "exon_count": 9,
          "intron_rank": null,
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          "gene_symbol": "PPARA",
          "gene_hgnc_id": 9232,
          "hgvs_c": "c.1183G>C",
          "hgvs_p": "p.Gly395Arg",
          "transcript": "NM_001393943.1",
          "protein_id": "NP_001380872.1",
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          "cdna_start": 1779,
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        {
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        {
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          "gene_symbol": "PPARA",
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          "hgvs_p": "p.Gly178Arg",
          "transcript": "NM_001393947.1",
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        {
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        {
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        {
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          "hgvs_c": "c.1183G>C",
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      ],
      "gene_symbol": "PPARA",
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      "dbsnp": "rs2229245",
      "frequency_reference_population": 0.000012392956,
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      "gnomad_mito_homoplasmic": null,
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      "computational_score_selected": 0.1253625750541687,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.05999999865889549,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
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      "revel_prediction": "Benign",
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      "bayesdelnoaf_score": -0.18,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 0.915,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0.06,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
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      "apogee2_score": null,
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      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -6,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4_Moderate,BS2",
      "acmg_by_gene": [
        {
          "score": -6,
          "benign_score": 6,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Moderate",
            "BS2"
          ],
          "verdict": "Likely_benign",
          "transcript": "ENST00000407236.6",
          "gene_symbol": "PPARA",
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          "effects": [
            "missense_variant"
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          "inheritance_mode": "AD",
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          "hgvs_p": "p.Gly395Arg"
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      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}