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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-100748388-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=100748388&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 100748388,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000240851.9",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1060C>T",
"hgvs_p": "p.Pro354Ser",
"transcript": "NM_006070.6",
"protein_id": "NP_006061.2",
"transcript_support_level": null,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1060,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1331,
"cdna_end": null,
"cdna_length": 1907,
"mane_select": "ENST00000240851.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1060C>T",
"hgvs_p": "p.Pro354Ser",
"transcript": "ENST00000240851.9",
"protein_id": "ENSP00000240851.4",
"transcript_support_level": 1,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1060,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1331,
"cdna_end": null,
"cdna_length": 1907,
"mane_select": "NM_006070.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1048C>T",
"hgvs_p": "p.Pro350Ser",
"transcript": "ENST00000476228.5",
"protein_id": "ENSP00000417952.1",
"transcript_support_level": 1,
"aa_start": 350,
"aa_end": null,
"aa_length": 396,
"cds_start": 1048,
"cds_end": null,
"cds_length": 1191,
"cdna_start": 1207,
"cdna_end": null,
"cdna_length": 1783,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.*246C>T",
"hgvs_p": null,
"transcript": "ENST00000615993.2",
"protein_id": "ENSP00000479269.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 280,
"cds_start": -4,
"cds_end": null,
"cds_length": 843,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1759,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1096C>T",
"hgvs_p": "p.Pro366Ser",
"transcript": "ENST00000675692.1",
"protein_id": "ENSP00000502034.1",
"transcript_support_level": null,
"aa_start": 366,
"aa_end": null,
"aa_length": 412,
"cds_start": 1096,
"cds_end": null,
"cds_length": 1239,
"cdna_start": 1432,
"cdna_end": null,
"cdna_length": 2008,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1060C>T",
"hgvs_p": "p.Pro354Ser",
"transcript": "NM_001007565.2",
"protein_id": "NP_001007566.1",
"transcript_support_level": null,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1060,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1245,
"cdna_end": null,
"cdna_length": 1824,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1060C>T",
"hgvs_p": "p.Pro354Ser",
"transcript": "NM_001195478.2",
"protein_id": "NP_001182407.1",
"transcript_support_level": null,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1060,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1198,
"cdna_end": null,
"cdna_length": 1774,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1060C>T",
"hgvs_p": "p.Pro354Ser",
"transcript": "ENST00000487505.6",
"protein_id": "ENSP00000420797.2",
"transcript_support_level": 3,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1060,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1429,
"cdna_end": null,
"cdna_length": 2005,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1060C>T",
"hgvs_p": "p.Pro354Ser",
"transcript": "ENST00000490574.6",
"protein_id": "ENSP00000419960.1",
"transcript_support_level": 3,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1060,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1240,
"cdna_end": null,
"cdna_length": 1816,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1060C>T",
"hgvs_p": "p.Pro354Ser",
"transcript": "ENST00000674615.1",
"protein_id": "ENSP00000502734.1",
"transcript_support_level": null,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1060,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1461,
"cdna_end": null,
"cdna_length": 2037,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1060C>T",
"hgvs_p": "p.Pro354Ser",
"transcript": "ENST00000675243.1",
"protein_id": "ENSP00000502592.1",
"transcript_support_level": null,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1060,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1278,
"cdna_end": null,
"cdna_length": 1854,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1060C>T",
"hgvs_p": "p.Pro354Ser",
"transcript": "ENST00000675499.1",
"protein_id": "ENSP00000502450.1",
"transcript_support_level": null,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1060,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1229,
"cdna_end": null,
"cdna_length": 1805,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1060C>T",
"hgvs_p": "p.Pro354Ser",
"transcript": "ENST00000675553.1",
"protein_id": "ENSP00000501815.1",
"transcript_support_level": null,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1060,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1330,
"cdna_end": null,
"cdna_length": 1906,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1060C>T",
"hgvs_p": "p.Pro354Ser",
"transcript": "ENST00000676395.1",
"protein_id": "ENSP00000502071.1",
"transcript_support_level": null,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1060,
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"cds_length": 1203,
"cdna_start": 1312,
"cdna_end": null,
"cdna_length": 1888,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1048C>T",
"hgvs_p": "p.Pro350Ser",
"transcript": "NM_001195479.2",
"protein_id": "NP_001182408.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 396,
"cds_start": 1048,
"cds_end": null,
"cds_length": 1191,
"cdna_start": 1319,
"cdna_end": null,
"cdna_length": 1895,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1048C>T",
"hgvs_p": "p.Pro350Ser",
"transcript": "ENST00000463568.6",
"protein_id": "ENSP00000419504.2",
"transcript_support_level": 3,
"aa_start": 350,
"aa_end": null,
"aa_length": 396,
"cds_start": 1048,
"cds_end": null,
"cds_length": 1191,
"cdna_start": 1300,
"cdna_end": null,
"cdna_length": 1876,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1048C>T",
"hgvs_p": "p.Pro350Ser",
"transcript": "ENST00000674645.1",
"protein_id": "ENSP00000501892.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 396,
"cds_start": 1048,
"cds_end": null,
"cds_length": 1191,
"cdna_start": 1384,
"cdna_end": null,
"cdna_length": 1960,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1048C>T",
"hgvs_p": "p.Pro350Ser",
"transcript": "ENST00000674758.1",
"protein_id": "ENSP00000502502.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 396,
"cds_start": 1048,
"cds_end": null,
"cds_length": 1191,
"cdna_start": 1439,
"cdna_end": null,
"cdna_length": 2015,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1048C>T",
"hgvs_p": "p.Pro350Ser",
"transcript": "ENST00000675047.1",
"protein_id": "ENSP00000502497.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 396,
"cds_start": 1048,
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"cdna_start": 1228,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1048C>T",
"hgvs_p": "p.Pro350Ser",
"transcript": "ENST00000675420.1",
"protein_id": "ENSP00000502516.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 396,
"cds_start": 1048,
"cds_end": null,
"cds_length": 1191,
"cdna_start": 1345,
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"cdna_length": 1921,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1048C>T",
"hgvs_p": "p.Pro350Ser",
"transcript": "ENST00000676431.1",
"protein_id": "ENSP00000502698.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 396,
"cds_start": 1048,
"cds_end": null,
"cds_length": 1191,
"cdna_start": 1217,
"cdna_end": null,
"cdna_length": 1793,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1060C>T",
"hgvs_p": "p.Pro354Ser",
"transcript": "XM_006713472.2",
"protein_id": "XP_006713535.1",
"transcript_support_level": null,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1060,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1431,
"cdna_end": null,
"cdna_length": 2010,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TFG",
"gene_hgnc_id": 11758,
"hgvs_c": "c.1060C>T",
"hgvs_p": "p.Pro354Ser",
"transcript": "XM_011512334.2",
"protein_id": "XP_011510636.1",
"transcript_support_level": null,
"aa_start": 354,
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{
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}
],
"message": null
}