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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 3-12288284-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=12288284&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 12,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "PPARG",
          "hgnc_id": 9236,
          "hgvs_c": "c.-9+264C>T",
          "hgvs_p": null,
          "inheritance_mode": "AD,AR,SD",
          "pathogenic_score": 0,
          "score": -12,
          "transcript": "NM_005037.7",
          "verdict": "Benign"
        }
      ],
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BA1",
      "acmg_score": -12,
      "allele_count_reference_population": 13402,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.81,
      "chr": "3",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": -0.8100000023841858,
      "computational_source_selected": "BayesDel_noAF",
      "consequences": [
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 475,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2017,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 8,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000397010.7",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-83+609C>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000380205.3",
          "strand": true,
          "transcript": "ENST00000397010.7",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 475,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1772,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000397015.7",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-9+264C>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000380210.3",
          "strand": true,
          "transcript": "ENST00000397015.7",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 475,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2017,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 8,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001354666.3",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-83+609C>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001341595.2",
          "strand": true,
          "transcript": "NM_001354666.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 475,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1782,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_005037.7",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-9+264C>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_005028.5",
          "strand": true,
          "transcript": "NM_005037.7",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 475,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1856,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 8,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_138712.5",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-83+264C>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_619726.3",
          "strand": true,
          "transcript": "NM_138712.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 475,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1870,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 8,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000309576.11",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-83+264C>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000312472.7",
          "strand": true,
          "transcript": "ENST00000309576.11",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 475,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1894,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 9,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000643197.2",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-412+264C>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000495840.2",
          "strand": true,
          "transcript": "ENST00000643197.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 475,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1693,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 9,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000643888.2",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-171+264C>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000494934.2",
          "strand": true,
          "transcript": "ENST00000643888.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 475,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1962,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 10,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000644622.2",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-484+264C>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000494873.2",
          "strand": true,
          "transcript": "ENST00000644622.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 475,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1897,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 9,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000892317.1",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-155+264C>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000562376.1",
          "strand": true,
          "transcript": "ENST00000892317.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 475,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2019,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
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          ],
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          "exon_rank": null,
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          "feature": "ENST00000892318.1",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-286+264C>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000562377.1",
          "strand": true,
          "transcript": "ENST00000892318.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 475,
          "aa_ref": null,
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          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2018,
          "cdna_start": null,
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          "cds_start": null,
          "consequences": [
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          ],
          "exon_count": 10,
          "exon_rank": null,
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          "feature": "ENST00000892319.1",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-301+264C>T",
          "hgvs_p": null,
          "intron_rank": 1,
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000562378.1",
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          "transcript": "ENST00000892319.1",
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        },
        {
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          "aa_ref": null,
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          "biotype": "protein_coding",
          "canonical": false,
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          "cdna_length": 1986,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 10,
          "exon_rank": null,
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          "feature": "ENST00000892321.1",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
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          "hgvs_p": null,
          "intron_rank": 1,
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000562380.1",
          "strand": true,
          "transcript": "ENST00000892321.1",
          "transcript_support_level": null
        },
        {
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          "aa_ref": null,
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          "cdna_start": null,
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          "consequences": [
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          "feature": "ENST00000892322.1",
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          "protein_coding": true,
          "protein_id": "ENSP00000562381.1",
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          "transcript": "ENST00000892322.1",
          "transcript_support_level": null
        },
        {
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          "aa_ref": null,
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          "biotype": "protein_coding",
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          "cdna_length": 1872,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 9,
          "exon_rank": null,
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          "feature": "ENST00000892323.1",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
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          "protein_coding": true,
          "protein_id": "ENSP00000562382.1",
          "strand": true,
          "transcript": "ENST00000892323.1",
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        },
        {
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          "cdna_length": 2196,
          "cdna_start": null,
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          "cds_start": null,
          "consequences": [
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          ],
          "exon_count": 9,
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          "feature": "ENST00000942257.1",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-412+609C>T",
          "hgvs_p": null,
          "intron_rank": 1,
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          "mane_plus": null,
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          "protein_coding": true,
          "protein_id": "ENSP00000612316.1",
          "strand": true,
          "transcript": "ENST00000942257.1",
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        },
        {
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          "cds_start": null,
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          ],
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          "feature": "ENST00000942258.1",
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          "transcript": "ENST00000942258.1",
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        },
        {
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          "cdna_length": 2476,
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          "cds_start": null,
          "consequences": [
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          ],
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          "feature": "ENST00000942259.1",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
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          "intron_rank": 1,
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          "protein_coding": true,
          "protein_id": "ENSP00000612318.1",
          "strand": true,
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          "transcript_support_level": null
        },
        {
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          "biotype": "protein_coding",
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          "cdna_length": 2140,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 9,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000942260.1",
          "gene_hgnc_id": 9236,
          "gene_symbol": "PPARG",
          "hgvs_c": "c.-357+264C>T",
          "hgvs_p": null,
          "intron_rank": 1,
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000612319.1",
          "strand": true,
          "transcript": "ENST00000942260.1",
          "transcript_support_level": null
        },
        {
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          "biotype": "protein_coding",
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          "cdna_end": null,
          "cdna_length": 1936,
          "cdna_start": null,
          "cds_end": null,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.