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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-12600233-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=12600233&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 12600233,
"ref": "T",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_001354689.3",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "NM_002880.4",
"protein_id": "NP_002871.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1240,
"cdna_end": null,
"cdna_length": 3191,
"mane_select": "ENST00000251849.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002880.4"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000251849.9",
"protein_id": "ENSP00000251849.4",
"transcript_support_level": 1,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1240,
"cdna_end": null,
"cdna_length": 3191,
"mane_select": "NM_002880.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000251849.9"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.969A>G",
"hgvs_p": "p.Thr323Thr",
"transcript": "NM_001354689.3",
"protein_id": "NP_001341618.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 668,
"cds_start": 969,
"cds_end": null,
"cds_length": 2007,
"cdna_start": 1300,
"cdna_end": null,
"cdna_length": 3251,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001354689.3"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.969A>G",
"hgvs_p": "p.Thr323Thr",
"transcript": "ENST00000442415.7",
"protein_id": "ENSP00000401888.2",
"transcript_support_level": 5,
"aa_start": 323,
"aa_end": null,
"aa_length": 668,
"cds_start": 969,
"cds_end": null,
"cds_length": 2007,
"cdna_start": 1300,
"cdna_end": null,
"cdna_length": 3251,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000442415.7"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.969A>G",
"hgvs_p": "p.Thr323Thr",
"transcript": "ENST00000900382.1",
"protein_id": "ENSP00000570441.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 668,
"cds_start": 969,
"cds_end": null,
"cds_length": 2007,
"cdna_start": 1095,
"cdna_end": null,
"cdna_length": 3046,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900382.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.969A>G",
"hgvs_p": "p.Thr323Thr",
"transcript": "ENST00000941486.1",
"protein_id": "ENSP00000611545.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 668,
"cds_start": 969,
"cds_end": null,
"cds_length": 2007,
"cdna_start": 1400,
"cdna_end": null,
"cdna_length": 3343,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941486.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "NM_001354690.3",
"protein_id": "NP_001341619.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1075,
"cdna_end": null,
"cdna_length": 3026,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001354690.3"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000685653.1",
"protein_id": "ENSP00000509968.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 2614,
"cdna_end": null,
"cdna_length": 4402,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000685653.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000691899.1",
"protein_id": "ENSP00000508763.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1075,
"cdna_end": null,
"cdna_length": 2983,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000691899.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000900375.1",
"protein_id": "ENSP00000570434.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1333,
"cdna_end": null,
"cdna_length": 3311,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900375.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000900377.1",
"protein_id": "ENSP00000570436.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1352,
"cdna_end": null,
"cdna_length": 3303,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900377.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000900381.1",
"protein_id": "ENSP00000570440.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1099,
"cdna_end": null,
"cdna_length": 3043,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900381.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000900383.1",
"protein_id": "ENSP00000570442.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 960,
"cdna_end": null,
"cdna_length": 2911,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000900383.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000941484.1",
"protein_id": "ENSP00000611543.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1725,
"cdna_end": null,
"cdna_length": 3666,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941484.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000941488.1",
"protein_id": "ENSP00000611547.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1379,
"cdna_end": null,
"cdna_length": 3328,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941488.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000941490.1",
"protein_id": "ENSP00000611549.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1128,
"cdna_end": null,
"cdna_length": 3071,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941490.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000941491.1",
"protein_id": "ENSP00000611550.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1064,
"cdna_end": null,
"cdna_length": 3007,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941491.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000941492.1",
"protein_id": "ENSP00000611551.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1035,
"cdna_end": null,
"cdna_length": 2981,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941492.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000941494.1",
"protein_id": "ENSP00000611553.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1025,
"cdna_end": null,
"cdna_length": 2966,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941494.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000941495.1",
"protein_id": "ENSP00000611554.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
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"cdna_start": 1061,
"cdna_end": null,
"cdna_length": 3002,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941495.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.909A>G",
"hgvs_p": "p.Thr303Thr",
"transcript": "ENST00000941496.1",
"protein_id": "ENSP00000611555.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 648,
"cds_start": 909,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1141,
"cdna_end": null,
"cdna_length": 3084,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941496.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RAF1",
"gene_hgnc_id": 9829,
"hgvs_c": "c.897A>G",
"hgvs_p": "p.Thr299Thr",
"transcript": "ENST00000690460.1",
"protein_id": "ENSP00000509106.1",
"transcript_support_level": null,
"aa_start": 299,
"aa_end": null,
"aa_length": 644,
"cds_start": 897,
"cds_end": null,
"cds_length": 1935,
"cdna_start": 1228,
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}
],
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}