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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-138211503-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=138211503&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 138211503,
"ref": "T",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000469044.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ARMC8",
"gene_hgnc_id": 24999,
"hgvs_c": "c.122+1610T>G",
"hgvs_p": null,
"transcript": "NM_001363941.2",
"protein_id": "NP_001350870.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 673,
"cds_start": -4,
"cds_end": null,
"cds_length": 2022,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4757,
"mane_select": "ENST00000469044.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ARMC8",
"gene_hgnc_id": 24999,
"hgvs_c": "c.122+1610T>G",
"hgvs_p": null,
"transcript": "ENST00000469044.6",
"protein_id": "ENSP00000419413.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 673,
"cds_start": -4,
"cds_end": null,
"cds_length": 2022,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4757,
"mane_select": "NM_001363941.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ARMC8",
"gene_hgnc_id": 24999,
"hgvs_c": "c.80+1610T>G",
"hgvs_p": null,
"transcript": "ENST00000481646.5",
"protein_id": "ENSP00000420333.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 659,
"cds_start": -4,
"cds_end": null,
"cds_length": 1980,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3043,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ARMC8",
"gene_hgnc_id": 24999,
"hgvs_c": "c.80+1610T>G",
"hgvs_p": null,
"transcript": "ENST00000358441.6",
"protein_id": "ENSP00000351221.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 385,
"cds_start": -4,
"cds_end": null,
"cds_length": 1158,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3181,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ARMC8",
"gene_hgnc_id": 24999,
"hgvs_c": "c.80+1610T>G",
"hgvs_p": null,
"transcript": "NM_015396.6",
"protein_id": "NP_056211.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 659,
"cds_start": -4,
"cds_end": null,
"cds_length": 1980,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4603,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ARMC8",
"gene_hgnc_id": 24999,
"hgvs_c": "c.122+1610T>G",
"hgvs_p": null,
"transcript": "NM_001267041.2",
"protein_id": "NP_001253970.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 642,
"cds_start": -4,
"cds_end": null,
"cds_length": 1929,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4733,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ARMC8",
"gene_hgnc_id": 24999,
"hgvs_c": "c.122+1610T>G",
"hgvs_p": null,
"transcript": "ENST00000538260.5",
"protein_id": "ENSP00000441592.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 642,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 4728,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ARMC8",
"gene_hgnc_id": 24999,
"hgvs_c": "c.-4-10423T>G",
"hgvs_p": null,
"transcript": "NM_001363942.1",
"protein_id": "NP_001350871.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 631,
"cds_start": -4,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4826,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ARMC8",
"gene_hgnc_id": 24999,
"hgvs_c": "c.-4-10423T>G",
"hgvs_p": null,
"transcript": "ENST00000491704.5",
"protein_id": "ENSP00000417304.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 631,
"cds_start": -4,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
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"cdna_length": 2777,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 21,
"intron_rank": 2,
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"gene_symbol": "ARMC8",
"gene_hgnc_id": 24999,
"hgvs_c": "c.122+1610T>G",
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"transcript": "NM_001267042.3",
"protein_id": "NP_001253971.1",
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"cds_start": -4,
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"gene_symbol": "ARMC8",
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"hgvs_c": "c.122+1610T>G",
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"transcript": "ENST00000461822.5",
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},
{
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],
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},
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],
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"gene_symbol": "ARMC8",
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],
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],
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},
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],
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],
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},
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],
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"gene_symbol": "ARMC8",
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"hgvs_c": "c.-4-10423T>G",
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"transcript": "ENST00000489213.5",
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},
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],
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"gene_symbol": "ARMC8",
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],
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"gene_symbol": "ARMC8",
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"transcript": "ENST00000466749.5",
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},
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],
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"intron_rank": 3,
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"gene_symbol": "ARMC8",
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"protein_id": "XP_006713628.1",
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}
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}