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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-180948154-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=180948154&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 180948154,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_001441509.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.271-193G>C",
"hgvs_p": null,
"transcript": "NM_005087.4",
"protein_id": "NP_005078.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 621,
"cds_start": null,
"cds_end": null,
"cds_length": 1866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000357559.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005087.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.271-193G>C",
"hgvs_p": null,
"transcript": "ENST00000357559.9",
"protein_id": "ENSP00000350170.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 621,
"cds_start": null,
"cds_end": null,
"cds_length": 1866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005087.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000357559.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.271-193G>C",
"hgvs_p": null,
"transcript": "ENST00000445140.6",
"protein_id": "ENSP00000388828.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 539,
"cds_start": null,
"cds_end": null,
"cds_length": 1620,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000445140.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.271-193G>C",
"hgvs_p": null,
"transcript": "NM_001441509.1",
"protein_id": "NP_001428438.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 677,
"cds_start": null,
"cds_end": null,
"cds_length": 2034,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001441509.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.271-193G>C",
"hgvs_p": null,
"transcript": "ENST00000963215.1",
"protein_id": "ENSP00000633274.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 675,
"cds_start": null,
"cds_end": null,
"cds_length": 2028,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000963215.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.271-193G>C",
"hgvs_p": null,
"transcript": "ENST00000963216.1",
"protein_id": "ENSP00000633275.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 661,
"cds_start": null,
"cds_end": null,
"cds_length": 1986,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000963216.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.271-193G>C",
"hgvs_p": null,
"transcript": "NM_001441510.1",
"protein_id": "NP_001428439.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 650,
"cds_start": null,
"cds_end": null,
"cds_length": 1953,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001441510.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.271-193G>C",
"hgvs_p": null,
"transcript": "ENST00000698794.1",
"protein_id": "ENSP00000513937.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 650,
"cds_start": null,
"cds_end": null,
"cds_length": 1953,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000698794.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.271-193G>C",
"hgvs_p": null,
"transcript": "NM_001441512.1",
"protein_id": "NP_001428441.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 648,
"cds_start": null,
"cds_end": null,
"cds_length": 1947,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001441512.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.271-193G>C",
"hgvs_p": null,
"transcript": "ENST00000917910.1",
"protein_id": "ENSP00000587969.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 619,
"cds_start": null,
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"cds_length": 1860,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000917910.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.232-193G>C",
"hgvs_p": null,
"transcript": "ENST00000480918.5",
"protein_id": "ENSP00000418097.1",
"transcript_support_level": 2,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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},
{
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"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
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"gene_symbol": "FXR1",
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"hgvs_c": "c.271-193G>C",
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"transcript": "NM_001441513.1",
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"aa_start": null,
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"cds_start": null,
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"biotype": "protein_coding",
"feature": "NM_001441513.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 4,
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"gene_symbol": "FXR1",
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"hgvs_c": "c.271-193G>C",
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"transcript": "ENST00000917912.1",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"gene_symbol": "FXR1",
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"hgvs_c": "c.271-193G>C",
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"transcript": "ENST00000963217.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 4,
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"gene_symbol": "FXR1",
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"hgvs_c": "c.271-193G>C",
"hgvs_p": null,
"transcript": "NM_001441514.1",
"protein_id": "NP_001428443.1",
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"cds_start": null,
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"biotype": "protein_coding",
"feature": "NM_001441514.1"
},
{
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],
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"gene_symbol": "FXR1",
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"hgvs_c": "c.271-193G>C",
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"transcript": "ENST00000698793.1",
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},
{
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],
"exon_rank": null,
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"exon_count": 16,
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"gene_symbol": "FXR1",
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"hgvs_c": "c.271-193G>C",
"hgvs_p": null,
"transcript": "ENST00000917916.1",
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"feature": "ENST00000917916.1"
},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.271-193G>C",
"hgvs_p": null,
"transcript": "ENST00000917911.1",
"protein_id": "ENSP00000587970.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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},
{
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"strand": true,
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],
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"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.124-193G>C",
"hgvs_p": null,
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},
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"strand": true,
"consequences": [
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],
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"intron_rank": 4,
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"gene_symbol": "FXR1",
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"hgvs_c": "c.271-193G>C",
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},
{
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"strand": true,
"consequences": [
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],
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"intron_rank": 5,
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"gene_symbol": "FXR1",
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"hgvs_c": "c.16-193G>C",
"hgvs_p": null,
"transcript": "NM_001013439.3",
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"aa_start": null,
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"biotype": "protein_coding",
"feature": "NM_001013439.3"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "FXR1",
"gene_hgnc_id": 4023,
"hgvs_c": "c.16-193G>C",
"hgvs_p": null,
"transcript": "ENST00000305586.11",
"protein_id": "ENSP00000307633.7",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 536,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000305586.11"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 14,
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