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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-185813873-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=185813873&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 185813873,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000382199.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "IGF2BP2",
"gene_hgnc_id": 28867,
"hgvs_c": "c.239+9280G>A",
"hgvs_p": null,
"transcript": "NM_006548.6",
"protein_id": "NP_006539.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 599,
"cds_start": -4,
"cds_end": null,
"cds_length": 1800,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4283,
"mane_select": "ENST00000382199.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "IGF2BP2",
"gene_hgnc_id": 28867,
"hgvs_c": "c.239+9280G>A",
"hgvs_p": null,
"transcript": "ENST00000382199.7",
"protein_id": "ENSP00000371634.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 599,
"cds_start": -4,
"cds_end": null,
"cds_length": 1800,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4283,
"mane_select": "NM_006548.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "IGF2BP2",
"gene_hgnc_id": 28867,
"hgvs_c": "c.239+9280G>A",
"hgvs_p": null,
"transcript": "ENST00000346192.7",
"protein_id": "ENSP00000320204.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 556,
"cds_start": -4,
"cds_end": null,
"cds_length": 1671,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3291,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "IGF2BP2",
"gene_hgnc_id": 28867,
"hgvs_c": "c.50+7139G>A",
"hgvs_p": null,
"transcript": "ENST00000421047.3",
"protein_id": "ENSP00000413787.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 536,
"cds_start": -4,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1711,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "IGF2BP2",
"gene_hgnc_id": 28867,
"hgvs_c": "c.239+9280G>A",
"hgvs_p": null,
"transcript": "NM_001291869.3",
"protein_id": "NP_001278798.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 605,
"cds_start": -4,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4301,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "IGF2BP2",
"gene_hgnc_id": 28867,
"hgvs_c": "c.239+9280G>A",
"hgvs_p": null,
"transcript": "ENST00000457616.6",
"protein_id": "ENSP00000410242.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 605,
"cds_start": -4,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3426,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "IGF2BP2",
"gene_hgnc_id": 28867,
"hgvs_c": "c.239+9280G>A",
"hgvs_p": null,
"transcript": "NM_001007225.3",
"protein_id": "NP_001007226.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 556,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "IGF2BP2",
"gene_hgnc_id": 28867,
"hgvs_c": "c.50+7139G>A",
"hgvs_p": null,
"transcript": "NM_001291872.3",
"protein_id": "NP_001278801.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 542,
"cds_start": -4,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4111,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "IGF2BP2",
"gene_hgnc_id": 28867,
"hgvs_c": "c.50+7139G>A",
"hgvs_p": null,
"transcript": "NM_001291873.3",
"protein_id": "NP_001278802.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 536,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "IGF2BP2",
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"hgvs_c": "c.50+7139G>A",
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"transcript": "NM_001291874.3",
"protein_id": "NP_001278803.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "IGF2BP2",
"gene_hgnc_id": 28867,
"hgvs_c": "c.-106+7139G>A",
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"transcript": "NM_001291875.3",
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},
{
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],
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},
{
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],
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"gene_symbol": "IGF2BP2",
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},
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],
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],
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},
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],
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"gene_symbol": "IGF2BP2",
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},
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],
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"hgvs_c": "c.239+9280G>A",
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"gene_symbol": "IGF2BP2",
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],
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"gene_symbol": "IGF2BP2",
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"hgvs_c": "c.35+9280G>A",
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"transcript": "XM_047447318.1",
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},
{
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],
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"gene_symbol": "IGF2BP2",
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"hgvs_c": "c.239+9280G>A",
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