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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 3-186677647-C-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=186677647&ref=C&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "3",
      "pos": 186677647,
      "ref": "C",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "ENST00000232003.5",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HRG",
          "gene_hgnc_id": 5181,
          "hgvs_c": "c.1342C>A",
          "hgvs_p": "p.Arg448Ser",
          "transcript": "NM_000412.5",
          "protein_id": "NP_000403.1",
          "transcript_support_level": null,
          "aa_start": 448,
          "aa_end": null,
          "aa_length": 525,
          "cds_start": 1342,
          "cds_end": null,
          "cds_length": 1578,
          "cdna_start": 1360,
          "cdna_end": null,
          "cdna_length": 1947,
          "mane_select": "ENST00000232003.5",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "S",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HRG",
          "gene_hgnc_id": 5181,
          "hgvs_c": "c.1342C>A",
          "hgvs_p": "p.Arg448Ser",
          "transcript": "ENST00000232003.5",
          "protein_id": "ENSP00000232003.4",
          "transcript_support_level": 1,
          "aa_start": 448,
          "aa_end": null,
          "aa_length": 525,
          "cds_start": 1342,
          "cds_end": null,
          "cds_length": 1578,
          "cdna_start": 1360,
          "cdna_end": null,
          "cdna_length": 1947,
          "mane_select": "NM_000412.5",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HRG",
          "gene_hgnc_id": 5181,
          "hgvs_c": "c.1366C>A",
          "hgvs_p": "p.Arg456Ser",
          "transcript": "XM_005247415.5",
          "protein_id": "XP_005247472.1",
          "transcript_support_level": null,
          "aa_start": 456,
          "aa_end": null,
          "aa_length": 533,
          "cds_start": 1366,
          "cds_end": null,
          "cds_length": 1602,
          "cdna_start": 1384,
          "cdna_end": null,
          "cdna_length": 1971,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HRG",
          "gene_hgnc_id": 5181,
          "hgvs_c": "n.3688C>A",
          "hgvs_p": null,
          "transcript": "ENST00000495413.1",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4272,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.215-10386G>T",
          "hgvs_p": null,
          "transcript": "ENST00000625303.2",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 950,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.214-35519G>T",
          "hgvs_p": null,
          "transcript": "ENST00000625386.2",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 529,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.327-25776G>T",
          "hgvs_p": null,
          "transcript": "ENST00000625741.2",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 653,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.215-2788G>T",
          "hgvs_p": null,
          "transcript": "ENST00000625839.2",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 423,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.169-8604G>T",
          "hgvs_p": null,
          "transcript": "ENST00000625877.1",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 472,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.215-35519G>T",
          "hgvs_p": null,
          "transcript": "ENST00000626633.2",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 438,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.51-25776G>T",
          "hgvs_p": null,
          "transcript": "ENST00000626649.2",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 667,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.340-25776G>T",
          "hgvs_p": null,
          "transcript": "ENST00000626845.2",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": -4,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 641,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.334-25776G>T",
          "hgvs_p": null,
          "transcript": "ENST00000627469.2",
          "protein_id": null,
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          "aa_start": null,
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          "cdna_start": null,
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          "cdna_length": 617,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
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        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 5,
          "intron_rank": 4,
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          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.504-10386G>T",
          "hgvs_p": null,
          "transcript": "ENST00000627830.2",
          "protein_id": null,
          "transcript_support_level": 5,
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          "cdna_length": 798,
          "mane_select": null,
          "mane_plus": null,
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        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.215-35353G>T",
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          "transcript": "ENST00000628190.2",
          "protein_id": null,
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        {
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          ],
          "exon_rank": null,
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          "intron_rank": 2,
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          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.215-25776G>T",
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          "transcript": "ENST00000628253.2",
          "protein_id": null,
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          "cdna_length": 775,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 4,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.215-35519G>T",
          "hgvs_p": null,
          "transcript": "ENST00000628505.2",
          "protein_id": null,
          "transcript_support_level": 5,
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          "feature": null
        },
        {
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.334-2788G>T",
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          "transcript": "ENST00000628728.2",
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          "intron_rank": 2,
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          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.239-8604G>T",
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          "transcript": "ENST00000629106.2",
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        },
        {
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          "intron_rank": 4,
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          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.419-25776G>T",
          "hgvs_p": null,
          "transcript": "ENST00000629451.2",
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          "mane_select": null,
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        },
        {
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          "canonical": false,
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          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HRG-AS1",
          "gene_hgnc_id": 55915,
          "hgvs_c": "n.238+40820G>T",
          "hgvs_p": null,
          "transcript": "ENST00000630178.2",
          "protein_id": null,
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          "aa_start": null,
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          "cds_start": -4,
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          "cdna_length": 729,
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        },
        {
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        },
        {
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          "gene_symbol": "HRG-AS1",
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        },
        {
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          "gene_symbol": "HRG-AS1",
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          "transcript": "ENST00000804467.1",
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      ],
      "gene_symbol": "HRG",
      "gene_hgnc_id": 5181,
      "dbsnp": "rs1042445",
      "frequency_reference_population": 0.0000012393616,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 2,
      "gnomad_exomes_af": 6.84078e-7,
      "gnomad_genomes_af": 0.00000658276,
      "gnomad_exomes_ac": 1,
      "gnomad_genomes_ac": 1,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.06203761696815491,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.014,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.1607,
      "alphamissense_prediction": "Benign",
      "bayesdelnoaf_score": -0.87,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": -0.405,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -2,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong",
      "acmg_by_gene": [
        {
          "score": -2,
          "benign_score": 4,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "verdict": "Likely_benign",
          "transcript": "ENST00000232003.5",
          "gene_symbol": "HRG",
          "hgnc_id": 5181,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.1342C>A",
          "hgvs_p": "p.Arg448Ser"
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        {
          "score": -2,
          "benign_score": 4,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "verdict": "Likely_benign",
          "transcript": "ENST00000804467.1",
          "gene_symbol": "HRG-AS1",
          "hgnc_id": 55915,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.322-35519G>T",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}