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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-195752385-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=195752385&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 195752385,
"ref": "T",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "ENST00000463781.8",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "c.15570A>G",
"hgvs_p": "p.Glu5190Glu",
"transcript": "NM_018406.7",
"protein_id": "NP_060876.5",
"transcript_support_level": null,
"aa_start": 5190,
"aa_end": null,
"aa_length": 5412,
"cds_start": 15570,
"cds_end": null,
"cds_length": 16239,
"cdna_start": 15682,
"cdna_end": null,
"cdna_length": 16756,
"mane_select": "ENST00000463781.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "c.15570A>G",
"hgvs_p": "p.Glu5190Glu",
"transcript": "ENST00000463781.8",
"protein_id": "ENSP00000417498.3",
"transcript_support_level": 5,
"aa_start": 5190,
"aa_end": null,
"aa_length": 5412,
"cds_start": 15570,
"cds_end": null,
"cds_length": 16239,
"cdna_start": 15682,
"cdna_end": null,
"cdna_length": 16756,
"mane_select": "NM_018406.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "c.2862A>G",
"hgvs_p": "p.Glu954Glu",
"transcript": "ENST00000346145.8",
"protein_id": "ENSP00000304207.6",
"transcript_support_level": 1,
"aa_start": 954,
"aa_end": null,
"aa_length": 1176,
"cds_start": 2862,
"cds_end": null,
"cds_length": 3531,
"cdna_start": 2902,
"cdna_end": null,
"cdna_length": 3982,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "c.2709A>G",
"hgvs_p": "p.Glu903Glu",
"transcript": "ENST00000349607.8",
"protein_id": "ENSP00000338109.4",
"transcript_support_level": 1,
"aa_start": 903,
"aa_end": null,
"aa_length": 1125,
"cds_start": 2709,
"cds_end": null,
"cds_length": 3378,
"cdna_start": 2749,
"cdna_end": null,
"cdna_length": 3829,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.*2202A>G",
"hgvs_p": null,
"transcript": "ENST00000308466.12",
"protein_id": "ENSP00000310528.8",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3806,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.*2263A>G",
"hgvs_p": null,
"transcript": "ENST00000339251.9",
"protein_id": "ENSP00000345378.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3777,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.*2131A>G",
"hgvs_p": null,
"transcript": "ENST00000392407.6",
"protein_id": "ENSP00000376208.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3645,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.*2202A>G",
"hgvs_p": null,
"transcript": "ENST00000415455.5",
"protein_id": "ENSP00000407750.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3716,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.*2370A>G",
"hgvs_p": null,
"transcript": "ENST00000448861.5",
"protein_id": "ENSP00000389780.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3944,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.*2202A>G",
"hgvs_p": null,
"transcript": "ENST00000308466.12",
"protein_id": "ENSP00000310528.8",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3806,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.*2263A>G",
"hgvs_p": null,
"transcript": "ENST00000339251.9",
"protein_id": "ENSP00000345378.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3777,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.*2131A>G",
"hgvs_p": null,
"transcript": "ENST00000392407.6",
"protein_id": "ENSP00000376208.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3645,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.*2202A>G",
"hgvs_p": null,
"transcript": "ENST00000415455.5",
"protein_id": "ENSP00000407750.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3716,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.*2370A>G",
"hgvs_p": null,
"transcript": "ENST00000448861.5",
"protein_id": "ENSP00000389780.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 3944,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "c.15414A>G",
"hgvs_p": "p.Glu5138Glu",
"transcript": "ENST00000475231.5",
"protein_id": "ENSP00000420243.1",
"transcript_support_level": 5,
"aa_start": 5138,
"aa_end": null,
"aa_length": 5360,
"cds_start": 15414,
"cds_end": null,
"cds_length": 16083,
"cdna_start": 15486,
"cdna_end": null,
"cdna_length": 16273,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "c.2862A>G",
"hgvs_p": "p.Glu954Glu",
"transcript": "NM_004532.6",
"protein_id": "NP_004523.3",
"transcript_support_level": null,
"aa_start": 954,
"aa_end": null,
"aa_length": 1176,
"cds_start": 2862,
"cds_end": null,
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"cdna_start": 2974,
"cdna_end": null,
"cdna_length": 4048,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "c.2709A>G",
"hgvs_p": "p.Glu903Glu",
"transcript": "NM_138297.5",
"protein_id": "NP_612154.2",
"transcript_support_level": null,
"aa_start": 903,
"aa_end": null,
"aa_length": 1125,
"cds_start": 2709,
"cds_end": null,
"cds_length": 3378,
"cdna_start": 2821,
"cdna_end": null,
"cdna_length": 3895,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.*2009A>G",
"hgvs_p": null,
"transcript": "ENST00000462323.5",
"protein_id": "ENSP00000417397.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 16197,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.1006A>G",
"hgvs_p": null,
"transcript": "ENST00000464234.5",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.*2291A>G",
"hgvs_p": null,
"transcript": "ENST00000466475.5",
"protein_id": "ENSP00000417722.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 16443,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.136A>G",
"hgvs_p": null,
"transcript": "ENST00000467235.1",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 2571,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.115A>G",
"hgvs_p": null,
"transcript": "ENST00000469992.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 698,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MUC4",
"gene_hgnc_id": 7514,
"hgvs_c": "n.*1975A>G",
"hgvs_p": null,
"transcript": "ENST00000470451.5",
"protein_id": "ENSP00000420439.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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}