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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-195868079-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=195868079&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 195868079,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001387707.1",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2219C>G",
"hgvs_p": "p.Pro740Arg",
"transcript": "NM_001382273.1",
"protein_id": "NP_001369202.1",
"transcript_support_level": null,
"aa_start": 740,
"aa_end": null,
"aa_length": 1055,
"cds_start": 2219,
"cds_end": null,
"cds_length": 3168,
"cdna_start": 2304,
"cdna_end": null,
"cdna_length": 4070,
"mane_select": "ENST00000672887.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382273.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2219C>G",
"hgvs_p": "p.Pro740Arg",
"transcript": "ENST00000672887.2",
"protein_id": "ENSP00000499899.1",
"transcript_support_level": null,
"aa_start": 740,
"aa_end": null,
"aa_length": 1055,
"cds_start": 2219,
"cds_end": null,
"cds_length": 3168,
"cdna_start": 2304,
"cdna_end": null,
"cdna_length": 4070,
"mane_select": "NM_001382273.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000672887.2"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2270C>G",
"hgvs_p": "p.Pro757Arg",
"transcript": "ENST00000428187.7",
"protein_id": "ENSP00000392546.1",
"transcript_support_level": 1,
"aa_start": 757,
"aa_end": null,
"aa_length": 1040,
"cds_start": 2270,
"cds_end": null,
"cds_length": 3123,
"cdna_start": 2566,
"cdna_end": null,
"cdna_length": 4235,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000428187.7"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2174C>G",
"hgvs_p": "p.Pro725Arg",
"transcript": "ENST00000333602.14",
"protein_id": "ENSP00000329425.6",
"transcript_support_level": 1,
"aa_start": 725,
"aa_end": null,
"aa_length": 1038,
"cds_start": 2174,
"cds_end": null,
"cds_length": 3117,
"cdna_start": 3510,
"cdna_end": null,
"cdna_length": 5270,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000333602.14"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2315C>G",
"hgvs_p": "p.Pro772Arg",
"transcript": "NM_001387707.1",
"protein_id": "NP_001374636.1",
"transcript_support_level": null,
"aa_start": 772,
"aa_end": null,
"aa_length": 1087,
"cds_start": 2315,
"cds_end": null,
"cds_length": 3264,
"cdna_start": 2571,
"cdna_end": null,
"cdna_length": 4337,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387707.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2408C>G",
"hgvs_p": "p.Pro803Arg",
"transcript": "ENST00000381916.7",
"protein_id": "ENSP00000371341.2",
"transcript_support_level": 2,
"aa_start": 803,
"aa_end": null,
"aa_length": 1086,
"cds_start": 2408,
"cds_end": null,
"cds_length": 3261,
"cdna_start": 2553,
"cdna_end": null,
"cdna_length": 4222,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000381916.7"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2291C>G",
"hgvs_p": "p.Pro764Arg",
"transcript": "NM_001382272.1",
"protein_id": "NP_001369201.1",
"transcript_support_level": null,
"aa_start": 764,
"aa_end": null,
"aa_length": 1079,
"cds_start": 2291,
"cds_end": null,
"cds_length": 3240,
"cdna_start": 2340,
"cdna_end": null,
"cdna_length": 4106,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382272.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2288C>G",
"hgvs_p": "p.Pro763Arg",
"transcript": "ENST00000863906.1",
"protein_id": "ENSP00000533965.1",
"transcript_support_level": null,
"aa_start": 763,
"aa_end": null,
"aa_length": 1078,
"cds_start": 2288,
"cds_end": null,
"cds_length": 3237,
"cdna_start": 2336,
"cdna_end": null,
"cdna_length": 4099,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863906.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2288C>G",
"hgvs_p": "p.Pro763Arg",
"transcript": "ENST00000863912.1",
"protein_id": "ENSP00000533971.1",
"transcript_support_level": null,
"aa_start": 763,
"aa_end": null,
"aa_length": 1078,
"cds_start": 2288,
"cds_end": null,
"cds_length": 3237,
"cdna_start": 2640,
"cdna_end": null,
"cdna_length": 4406,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863912.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2270C>G",
"hgvs_p": "p.Pro757Arg",
"transcript": "NM_001382271.1",
"protein_id": "NP_001369200.1",
"transcript_support_level": null,
"aa_start": 757,
"aa_end": null,
"aa_length": 1072,
"cds_start": 2270,
"cds_end": null,
"cds_length": 3219,
"cdna_start": 2526,
"cdna_end": null,
"cdna_length": 4292,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382271.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2270C>G",
"hgvs_p": "p.Pro757Arg",
"transcript": "ENST00000673038.1",
"protein_id": "ENSP00000500452.1",
"transcript_support_level": null,
"aa_start": 757,
"aa_end": null,
"aa_length": 1072,
"cds_start": 2270,
"cds_end": null,
"cds_length": 3219,
"cdna_start": 2510,
"cdna_end": null,
"cdna_length": 4276,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000673038.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2270C>G",
"hgvs_p": "p.Pro757Arg",
"transcript": "ENST00000678220.1",
"protein_id": "ENSP00000503221.1",
"transcript_support_level": null,
"aa_start": 757,
"aa_end": null,
"aa_length": 1072,
"cds_start": 2270,
"cds_end": null,
"cds_length": 3219,
"cdna_start": 2526,
"cdna_end": null,
"cdna_length": 4292,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000678220.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2246C>G",
"hgvs_p": "p.Pro749Arg",
"transcript": "NM_001387708.1",
"protein_id": "NP_001374637.1",
"transcript_support_level": null,
"aa_start": 749,
"aa_end": null,
"aa_length": 1064,
"cds_start": 2246,
"cds_end": null,
"cds_length": 3195,
"cdna_start": 2295,
"cdna_end": null,
"cdna_length": 4061,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387708.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2219C>G",
"hgvs_p": "p.Pro740Arg",
"transcript": "NM_001382274.1",
"protein_id": "NP_001369203.1",
"transcript_support_level": null,
"aa_start": 740,
"aa_end": null,
"aa_length": 1055,
"cds_start": 2219,
"cds_end": null,
"cds_length": 3168,
"cdna_start": 2285,
"cdna_end": null,
"cdna_length": 4051,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382274.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2315C>G",
"hgvs_p": "p.Pro772Arg",
"transcript": "NM_001382275.1",
"protein_id": "NP_001369204.1",
"transcript_support_level": null,
"aa_start": 772,
"aa_end": null,
"aa_length": 1055,
"cds_start": 2315,
"cds_end": null,
"cds_length": 3168,
"cdna_start": 2571,
"cdna_end": null,
"cdna_length": 4241,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382275.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2219C>G",
"hgvs_p": "p.Pro740Arg",
"transcript": "ENST00000863904.1",
"protein_id": "ENSP00000533963.1",
"transcript_support_level": null,
"aa_start": 740,
"aa_end": null,
"aa_length": 1055,
"cds_start": 2219,
"cds_end": null,
"cds_length": 3168,
"cdna_start": 2299,
"cdna_end": null,
"cdna_length": 4065,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863904.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2219C>G",
"hgvs_p": "p.Pro740Arg",
"transcript": "ENST00000863911.1",
"protein_id": "ENSP00000533970.1",
"transcript_support_level": null,
"aa_start": 740,
"aa_end": null,
"aa_length": 1055,
"cds_start": 2219,
"cds_end": null,
"cds_length": 3168,
"cdna_start": 2577,
"cdna_end": null,
"cdna_length": 4343,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863911.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2291C>G",
"hgvs_p": "p.Pro764Arg",
"transcript": "NM_001010938.2",
"protein_id": "NP_001010938.2",
"transcript_support_level": null,
"aa_start": 764,
"aa_end": null,
"aa_length": 1047,
"cds_start": 2291,
"cds_end": null,
"cds_length": 3144,
"cdna_start": 2340,
"cdna_end": null,
"cdna_length": 4010,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001010938.2"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2291C>G",
"hgvs_p": "p.Pro764Arg",
"transcript": "ENST00000671753.1",
"protein_id": "ENSP00000499858.1",
"transcript_support_level": null,
"aa_start": 764,
"aa_end": null,
"aa_length": 1047,
"cds_start": 2291,
"cds_end": null,
"cds_length": 3144,
"cdna_start": 2553,
"cdna_end": null,
"cdna_length": 4223,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000671753.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2270C>G",
"hgvs_p": "p.Pro757Arg",
"transcript": "NM_001308046.2",
"protein_id": "NP_001294975.1",
"transcript_support_level": null,
"aa_start": 757,
"aa_end": null,
"aa_length": 1040,
"cds_start": 2270,
"cds_end": null,
"cds_length": 3123,
"cdna_start": 2526,
"cdna_end": null,
"cdna_length": 4196,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001308046.2"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2174C>G",
"hgvs_p": "p.Pro725Arg",
"transcript": "NM_001386164.1",
"protein_id": "NP_001373093.1",
"transcript_support_level": null,
"aa_start": 725,
"aa_end": null,
"aa_length": 1040,
"cds_start": 2174,
"cds_end": null,
"cds_length": 3123,
"cdna_start": 2259,
"cdna_end": null,
"cdna_length": 4025,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001386164.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNK2",
"gene_hgnc_id": 19297,
"hgvs_c": "c.2174C>G",
"hgvs_p": "p.Pro725Arg",
"transcript": "NM_001387709.1",
"protein_id": "NP_001374638.1",
"transcript_support_level": null,
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}