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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-20179220-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=20179220&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 20179220,
"ref": "G",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000412997.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SGO1",
"gene_hgnc_id": 25088,
"hgvs_c": "c.340-873C>A",
"hgvs_p": null,
"transcript": "NM_001199251.3",
"protein_id": "NP_001186180.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 527,
"cds_start": -4,
"cds_end": null,
"cds_length": 1584,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3070,
"mane_select": "ENST00000412997.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SGO1",
"gene_hgnc_id": 25088,
"hgvs_c": "c.340-873C>A",
"hgvs_p": null,
"transcript": "ENST00000412997.6",
"protein_id": "ENSP00000410458.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 527,
"cds_start": -4,
"cds_end": null,
"cds_length": 1584,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3070,
"mane_select": "NM_001199251.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SGO1",
"gene_hgnc_id": 25088,
"hgvs_c": "c.340-873C>A",
"hgvs_p": null,
"transcript": "ENST00000263753.8",
"protein_id": "ENSP00000263753.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 561,
"cds_start": -4,
"cds_end": null,
"cds_length": 1686,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2338,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SGO1",
"gene_hgnc_id": 25088,
"hgvs_c": "c.340-873C>A",
"hgvs_p": null,
"transcript": "ENST00000421451.5",
"protein_id": "ENSP00000414129.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 561,
"cds_start": -4,
"cds_end": null,
"cds_length": 1686,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1969,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SGO1",
"gene_hgnc_id": 25088,
"hgvs_c": "c.340-873C>A",
"hgvs_p": null,
"transcript": "ENST00000419233.6",
"protein_id": "ENSP00000394625.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 309,
"cds_start": -4,
"cds_end": null,
"cds_length": 930,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1582,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SGO1",
"gene_hgnc_id": 25088,
"hgvs_c": "c.340-873C>A",
"hgvs_p": null,
"transcript": "ENST00000425061.5",
"protein_id": "ENSP00000414960.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 309,
"cds_start": -4,
"cds_end": null,
"cds_length": 930,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1213,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SGO1",
"gene_hgnc_id": 25088,
"hgvs_c": "c.340-873C>A",
"hgvs_p": null,
"transcript": "ENST00000306698.6",
"protein_id": "ENSP00000306581.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 292,
"cds_start": -4,
"cds_end": null,
"cds_length": 879,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1531,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SGO1",
"gene_hgnc_id": 25088,
"hgvs_c": "c.340-873C>A",
"hgvs_p": null,
"transcript": "ENST00000452020.5",
"protein_id": "ENSP00000411200.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 292,
"cds_start": -4,
"cds_end": null,
"cds_length": 879,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1162,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SGO1",
"gene_hgnc_id": 25088,
"hgvs_c": "c.340-873C>A",
"hgvs_p": null,
"transcript": "ENST00000417364.1",
"protein_id": "ENSP00000394613.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 275,
"cds_start": -4,
"cds_end": null,
"cds_length": 828,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1075,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SGO1",
"gene_hgnc_id": 25088,
"hgvs_c": "c.340-873C>A",
"hgvs_p": null,
"transcript": "ENST00000437051.5",
"protein_id": "ENSP00000389034.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 275,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SGO1",
"gene_hgnc_id": 25088,
"hgvs_c": "c.340-873C>A",
"hgvs_p": null,
"transcript": "ENST00000442720.5",
"protein_id": "ENSP00000394957.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
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"gene_symbol": "SGO1",
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"hgvs_c": "c.340-873C>A",
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"transcript": "ENST00000443724.5",
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},
{
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"strand": false,
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],
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"exon_count": 9,
"intron_rank": 3,
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"gene_symbol": "SGO1",
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"hgvs_c": "c.340-873C>A",
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"transcript": "NM_001012410.5",
"protein_id": "NP_001012410.1",
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},
{
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"strand": false,
"consequences": [
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],
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"exon_count": 9,
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"gene_symbol": "SGO1",
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"hgvs_c": "c.340-873C>A",
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"transcript": "NM_001199252.3",
"protein_id": "NP_001186181.1",
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},
{
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],
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"gene_symbol": "SGO1",
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"transcript": "NM_001012409.4",
"protein_id": "NP_001012409.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 3,
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"gene_symbol": "SGO1",
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"hgvs_c": "c.340-873C>A",
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"transcript": "NM_001012412.5",
"protein_id": "NP_001012412.1",
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},
{
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],
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"gene_symbol": "SGO1",
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"hgvs_c": "c.340-873C>A",
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"transcript": "NM_001199254.3",
"protein_id": "NP_001186183.1",
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},
{
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"consequences": [
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],
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"exon_count": 8,
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"gene_symbol": "SGO1",
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"hgvs_c": "c.340-873C>A",
"hgvs_p": null,
"transcript": "NM_001199256.3",
"protein_id": "NP_001186185.1",
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},
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],
"exon_rank": null,
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"intron_rank": 3,
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"gene_symbol": "SGO1",
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"hgvs_c": "c.340-873C>A",
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"transcript": "NM_138484.5",
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},
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],
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"gene_symbol": "SGO1",
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},
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 3,
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"gene_symbol": "SGO1",
"gene_hgnc_id": 25088,
"hgvs_c": "c.340-873C>A",
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"transcript": "NM_001012413.4",
"protein_id": "NP_001012413.1",
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"biotype": null,
"feature": null
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SGO1",
"gene_hgnc_id": 25088,
"hgvs_c": "c.340-873C>A",
"hgvs_p": null,
"transcript": "NM_001199255.3",
"protein_id": "NP_001186184.1",
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},
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