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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-45901638-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=45901638&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 45901638,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000357632.7",
"consequences": [
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCR9",
"gene_hgnc_id": 1610,
"hgvs_c": "c.850A>G",
"hgvs_p": "p.Met284Val",
"transcript": "NM_031200.3",
"protein_id": "NP_112477.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 369,
"cds_start": 850,
"cds_end": null,
"cds_length": 1110,
"cdna_start": 991,
"cdna_end": null,
"cdna_length": 2527,
"mane_select": "ENST00000357632.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCR9",
"gene_hgnc_id": 1610,
"hgvs_c": "c.850A>G",
"hgvs_p": "p.Met284Val",
"transcript": "ENST00000357632.7",
"protein_id": "ENSP00000350256.2",
"transcript_support_level": 1,
"aa_start": 284,
"aa_end": null,
"aa_length": 369,
"cds_start": 850,
"cds_end": null,
"cds_length": 1110,
"cdna_start": 991,
"cdna_end": null,
"cdna_length": 2527,
"mane_select": "NM_031200.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCR9",
"gene_hgnc_id": 1610,
"hgvs_c": "c.814A>G",
"hgvs_p": "p.Met272Val",
"transcript": "ENST00000395963.2",
"protein_id": "ENSP00000379292.2",
"transcript_support_level": 1,
"aa_start": 272,
"aa_end": null,
"aa_length": 357,
"cds_start": 814,
"cds_end": null,
"cds_length": 1074,
"cdna_start": 976,
"cdna_end": null,
"cdna_length": 2512,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCR9",
"gene_hgnc_id": 1610,
"hgvs_c": "c.*612A>G",
"hgvs_p": null,
"transcript": "ENST00000422395.1",
"protein_id": "ENSP00000393267.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 107,
"cds_start": -4,
"cds_end": null,
"cds_length": 324,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1331,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCR9",
"gene_hgnc_id": 1610,
"hgvs_c": "c.850A>G",
"hgvs_p": "p.Met284Val",
"transcript": "NM_001386447.1",
"protein_id": "NP_001373376.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 369,
"cds_start": 850,
"cds_end": null,
"cds_length": 1110,
"cdna_start": 963,
"cdna_end": null,
"cdna_length": 2499,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCR9",
"gene_hgnc_id": 1610,
"hgvs_c": "c.850A>G",
"hgvs_p": "p.Met284Val",
"transcript": "NM_001386448.1",
"protein_id": "NP_001373377.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 369,
"cds_start": 850,
"cds_end": null,
"cds_length": 1110,
"cdna_start": 944,
"cdna_end": null,
"cdna_length": 2480,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCR9",
"gene_hgnc_id": 1610,
"hgvs_c": "c.814A>G",
"hgvs_p": "p.Met272Val",
"transcript": "NM_001256369.2",
"protein_id": "NP_001243298.1",
"transcript_support_level": null,
"aa_start": 272,
"aa_end": null,
"aa_length": 357,
"cds_start": 814,
"cds_end": null,
"cds_length": 1074,
"cdna_start": 1077,
"cdna_end": null,
"cdna_length": 2613,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCR9",
"gene_hgnc_id": 1610,
"hgvs_c": "c.814A>G",
"hgvs_p": "p.Met272Val",
"transcript": "NM_006641.4",
"protein_id": "NP_006632.2",
"transcript_support_level": null,
"aa_start": 272,
"aa_end": null,
"aa_length": 357,
"cds_start": 814,
"cds_end": null,
"cds_length": 1074,
"cdna_start": 942,
"cdna_end": null,
"cdna_length": 2478,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCR9",
"gene_hgnc_id": 1610,
"hgvs_c": "c.814A>G",
"hgvs_p": "p.Met272Val",
"transcript": "ENST00000706789.1",
"protein_id": "ENSP00000516552.1",
"transcript_support_level": null,
"aa_start": 272,
"aa_end": null,
"aa_length": 357,
"cds_start": 814,
"cds_end": null,
"cds_length": 1074,
"cdna_start": 2404,
"cdna_end": null,
"cdna_length": 3646,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "c.27+11482T>C",
"hgvs_p": null,
"transcript": "NM_001405920.1",
"protein_id": "NP_001392849.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 307,
"cds_start": -4,
"cds_end": null,
"cds_length": 924,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4257,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "c.27+11482T>C",
"hgvs_p": null,
"transcript": "NM_001405921.1",
"protein_id": "NP_001392850.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 295,
"cds_start": -4,
"cds_end": null,
"cds_length": 888,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4221,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "c.-138+11482T>C",
"hgvs_p": null,
"transcript": "NM_001276378.2",
"protein_id": "NP_001263307.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 282,
"cds_start": -4,
"cds_end": null,
"cds_length": 849,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4346,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "c.-177+11482T>C",
"hgvs_p": null,
"transcript": "NM_001405923.1",
"protein_id": "NP_001392852.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 282,
"cds_start": -4,
"cds_end": null,
"cds_length": 849,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4385,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "c.27+11482T>C",
"hgvs_p": null,
"transcript": "NM_001405925.1",
"protein_id": "NP_001392854.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 268,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "c.27+11482T>C",
"hgvs_p": null,
"transcript": "NM_001276379.2",
"protein_id": "NP_001263308.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 256,
"cds_start": -4,
"cds_end": null,
"cds_length": 771,
"cdna_start": null,
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"cdna_length": 4117,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "c.27+11482T>C",
"hgvs_p": null,
"transcript": "ENST00000539217.5",
"protein_id": "ENSP00000441784.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "c.-177+11482T>C",
"hgvs_p": null,
"transcript": "NM_001405926.1",
"protein_id": "NP_001392855.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 243,
"cds_start": -4,
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"cds_length": 732,
"cdna_start": null,
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"cdna_length": 4281,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "c.-138+11482T>C",
"hgvs_p": null,
"transcript": "NM_001405927.1",
"protein_id": "NP_001392856.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 243,
"cds_start": -4,
"cds_end": null,
"cds_length": 732,
"cdna_start": null,
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"cdna_length": 4242,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "c.-49+11482T>C",
"hgvs_p": null,
"transcript": "ENST00000492333.5",
"protein_id": "ENSP00000505957.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
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"cds_start": -4,
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"cds_length": 192,
"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "c.-215+11482T>C",
"hgvs_p": null,
"transcript": "ENST00000472635.5",
"protein_id": "ENSP00000506465.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 20,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "n.27+11482T>C",
"hgvs_p": null,
"transcript": "ENST00000418700.6",
"protein_id": "ENSP00000416427.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "n.350+11482T>C",
"hgvs_p": null,
"transcript": "ENST00000483279.1",
"protein_id": null,
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 566,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "LZTFL1",
"gene_hgnc_id": 6741,
"hgvs_c": "n.401+11482T>C",
"hgvs_p": null,
"transcript": "ENST00000699188.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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}
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}