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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-49402292-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=49402292&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 49402292,
"ref": "A",
"alt": "T",
"effect": "intron_variant",
"transcript": "NM_001664.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RHOA",
"gene_hgnc_id": 667,
"hgvs_c": "c.-3+9528T>A",
"hgvs_p": null,
"transcript": "NM_001664.4",
"protein_id": "NP_001655.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 193,
"cds_start": null,
"cds_end": null,
"cds_length": 582,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1805,
"mane_select": "ENST00000418115.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001664.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RHOA",
"gene_hgnc_id": 667,
"hgvs_c": "c.-3+9528T>A",
"hgvs_p": null,
"transcript": "ENST00000418115.6",
"protein_id": "ENSP00000400175.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 193,
"cds_start": null,
"cds_end": null,
"cds_length": 582,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1805,
"mane_select": "NM_001664.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000418115.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ENSG00000290318",
"gene_hgnc_id": null,
"hgvs_c": "c.-3+9528T>A",
"hgvs_p": null,
"transcript": "ENST00000704381.1",
"protein_id": "ENSP00000515884.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 163,
"cds_start": null,
"cds_end": null,
"cds_length": 492,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1270,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000704381.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RHOA",
"gene_hgnc_id": 667,
"hgvs_c": "c.-3+9528T>A",
"hgvs_p": null,
"transcript": "ENST00000880080.1",
"protein_id": "ENSP00000550139.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 207,
"cds_start": null,
"cds_end": null,
"cds_length": 624,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1962,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000880080.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RHOA",
"gene_hgnc_id": 667,
"hgvs_c": "c.-3+4420T>A",
"hgvs_p": null,
"transcript": "NM_001313941.2",
"protein_id": "NP_001300870.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 193,
"cds_start": null,
"cds_end": null,
"cds_length": 582,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1900,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001313941.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RHOA",
"gene_hgnc_id": 667,
"hgvs_c": "c.-3+4420T>A",
"hgvs_p": null,
"transcript": "ENST00000445425.6",
"protein_id": "ENSP00000408402.3",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 193,
"cds_start": null,
"cds_end": null,
"cds_length": 582,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1897,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000445425.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RHOA",
"gene_hgnc_id": 667,
"hgvs_c": "c.-3+10112T>A",
"hgvs_p": null,
"transcript": "ENST00000678200.1",
"protein_id": "ENSP00000504180.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 193,
"cds_start": null,
"cds_end": null,
"cds_length": 582,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1789,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000678200.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RHOA",
"gene_hgnc_id": 667,
"hgvs_c": "c.-3+9031T>A",
"hgvs_p": null,
"transcript": "ENST00000679208.1",
"protein_id": "ENSP00000503282.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 193,
"cds_start": null,
"cds_end": null,
"cds_length": 582,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1971,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000679208.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RHOA",
"gene_hgnc_id": 667,
"hgvs_c": "c.-37+9528T>A",
"hgvs_p": null,
"transcript": "ENST00000880082.1",
"protein_id": "ENSP00000550141.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 193,
"cds_start": null,
"cds_end": null,
"cds_length": 582,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1852,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000880082.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RHOA",
"gene_hgnc_id": 667,
"hgvs_c": "c.-120-5170T>A",
"hgvs_p": null,
"transcript": "ENST00000880083.1",
"protein_id": "ENSP00000550142.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 193,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": 1926,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000880083.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "RHOA",
"gene_hgnc_id": 667,
"hgvs_c": "c.-182+9528T>A",
"hgvs_p": null,
"transcript": "ENST00000880084.1",
"protein_id": "ENSP00000550143.1",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"feature": "ENST00000880084.1"
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"gene_symbol": "RHOA",
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"transcript": "ENST00000880085.1",
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"feature": "ENST00000880085.1"
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "RHOA",
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"hgvs_c": "c.-247-7209T>A",
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"transcript": "ENST00000918056.1",
"protein_id": "ENSP00000588115.1",
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"cdna_start": null,
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},
{
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"strand": false,
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],
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"gene_symbol": "RHOA",
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},
{
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"strand": false,
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"intron_variant"
],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "RHOA",
"gene_hgnc_id": 667,
"hgvs_c": "c.-126+9528T>A",
"hgvs_p": null,
"transcript": "ENST00000918061.1",
"protein_id": "ENSP00000588120.1",
"transcript_support_level": null,
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"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
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},
{
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],
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"gene_symbol": "RHOA",
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},
{
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "RHOA",
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"hgvs_c": "c.-3+8902T>A",
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"transcript": "ENST00000918065.1",
"protein_id": "ENSP00000588124.1",
"transcript_support_level": null,
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},
{
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"strand": false,
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RHOA",
"gene_hgnc_id": 667,
"hgvs_c": "c.-3+8994T>A",
"hgvs_p": null,
"transcript": "ENST00000918066.1",
"protein_id": "ENSP00000588125.1",
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"aa_start": null,
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},
{
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"strand": false,
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],
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"exon_count": 5,
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"gene_symbol": "RHOA",
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"hgvs_c": "c.-28+9528T>A",
"hgvs_p": null,
"transcript": "ENST00000960736.1",
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},
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"consequences": [
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],
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},
{
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],
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"gene_symbol": "RHOA",
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"hgvs_c": "c.-3+4420T>A",
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"transcript": "ENST00000960738.1",
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"biotype": "protein_coding",
"feature": "ENST00000960738.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RHOA",
"gene_hgnc_id": 667,
"hgvs_c": "c.-3+2194T>A",
"hgvs_p": null,
"transcript": "ENST00000960739.1",
"protein_id": "ENSP00000630798.1",
"transcript_support_level": null,
"aa_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000960739.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
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