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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-3037423-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=3037423&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 3037423,
"ref": "T",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_182982.3",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1457T>A",
"hgvs_p": "p.Val486Glu",
"transcript": "NM_182982.3",
"protein_id": "NP_892027.2",
"transcript_support_level": null,
"aa_start": 486,
"aa_end": null,
"aa_length": 578,
"cds_start": 1457,
"cds_end": null,
"cds_length": 1737,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000398052.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_182982.3"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1457T>A",
"hgvs_p": "p.Val486Glu",
"transcript": "ENST00000398052.9",
"protein_id": "ENSP00000381129.4",
"transcript_support_level": 1,
"aa_start": 486,
"aa_end": null,
"aa_length": 578,
"cds_start": 1457,
"cds_end": null,
"cds_length": 1737,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_182982.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000398052.9"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1361T>A",
"hgvs_p": "p.Val454Glu",
"transcript": "ENST00000345167.10",
"protein_id": "ENSP00000264764.8",
"transcript_support_level": 1,
"aa_start": 454,
"aa_end": null,
"aa_length": 546,
"cds_start": 1361,
"cds_end": null,
"cds_length": 1641,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000345167.10"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1457T>A",
"hgvs_p": "p.Val486Glu",
"transcript": "ENST00000504933.1",
"protein_id": "ENSP00000427445.1",
"transcript_support_level": 1,
"aa_start": 486,
"aa_end": null,
"aa_length": 532,
"cds_start": 1457,
"cds_end": null,
"cds_length": 1599,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000504933.1"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1361T>A",
"hgvs_p": "p.Val454Glu",
"transcript": "ENST00000398051.8",
"protein_id": "ENSP00000381128.4",
"transcript_support_level": 1,
"aa_start": 454,
"aa_end": null,
"aa_length": 500,
"cds_start": 1361,
"cds_end": null,
"cds_length": 1503,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000398051.8"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1361T>A",
"hgvs_p": "p.Val454Glu",
"transcript": "NM_001004056.2",
"protein_id": "NP_001004056.1",
"transcript_support_level": null,
"aa_start": 454,
"aa_end": null,
"aa_length": 546,
"cds_start": 1361,
"cds_end": null,
"cds_length": 1641,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001004056.2"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1457T>A",
"hgvs_p": "p.Val486Glu",
"transcript": "NM_001004057.2",
"protein_id": "NP_001004057.1",
"transcript_support_level": null,
"aa_start": 486,
"aa_end": null,
"aa_length": 532,
"cds_start": 1457,
"cds_end": null,
"cds_length": 1599,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001004057.2"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1412T>A",
"hgvs_p": "p.Val471Glu",
"transcript": "ENST00000967906.1",
"protein_id": "ENSP00000637965.1",
"transcript_support_level": null,
"aa_start": 471,
"aa_end": null,
"aa_length": 517,
"cds_start": 1412,
"cds_end": null,
"cds_length": 1554,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967906.1"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1361T>A",
"hgvs_p": "p.Val454Glu",
"transcript": "NM_005307.3",
"protein_id": "NP_005298.2",
"transcript_support_level": null,
"aa_start": 454,
"aa_end": null,
"aa_length": 500,
"cds_start": 1361,
"cds_end": null,
"cds_length": 1503,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005307.3"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1211T>A",
"hgvs_p": "p.Val404Glu",
"transcript": "ENST00000967905.1",
"protein_id": "ENSP00000637964.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 450,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967905.1"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.875T>A",
"hgvs_p": "p.Val292Glu",
"transcript": "NM_001350173.2",
"protein_id": "NP_001337102.1",
"transcript_support_level": null,
"aa_start": 292,
"aa_end": null,
"aa_length": 384,
"cds_start": 875,
"cds_end": null,
"cds_length": 1155,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001350173.2"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1574T>A",
"hgvs_p": "p.Val525Glu",
"transcript": "XM_011513447.3",
"protein_id": "XP_011511749.1",
"transcript_support_level": null,
"aa_start": 525,
"aa_end": null,
"aa_length": 617,
"cds_start": 1574,
"cds_end": null,
"cds_length": 1854,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011513447.3"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1574T>A",
"hgvs_p": "p.Val525Glu",
"transcript": "XM_011513448.3",
"protein_id": "XP_011511750.1",
"transcript_support_level": null,
"aa_start": 525,
"aa_end": null,
"aa_length": 611,
"cds_start": 1574,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011513448.3"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1496T>A",
"hgvs_p": "p.Val499Glu",
"transcript": "XM_017008052.2",
"protein_id": "XP_016863541.1",
"transcript_support_level": null,
"aa_start": 499,
"aa_end": null,
"aa_length": 591,
"cds_start": 1496,
"cds_end": null,
"cds_length": 1776,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017008052.2"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1484T>A",
"hgvs_p": "p.Val495Glu",
"transcript": "XM_017008053.2",
"protein_id": "XP_016863542.1",
"transcript_support_level": null,
"aa_start": 495,
"aa_end": null,
"aa_length": 587,
"cds_start": 1484,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017008053.2"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1478T>A",
"hgvs_p": "p.Val493Glu",
"transcript": "XM_011513449.3",
"protein_id": "XP_011511751.1",
"transcript_support_level": null,
"aa_start": 493,
"aa_end": null,
"aa_length": 585,
"cds_start": 1478,
"cds_end": null,
"cds_length": 1758,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011513449.3"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1574T>A",
"hgvs_p": "p.Val525Glu",
"transcript": "XM_011513450.3",
"protein_id": "XP_011511752.1",
"transcript_support_level": null,
"aa_start": 525,
"aa_end": null,
"aa_length": 571,
"cds_start": 1574,
"cds_end": null,
"cds_length": 1716,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011513450.3"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1436T>A",
"hgvs_p": "p.Val479Glu",
"transcript": "XM_011513451.3",
"protein_id": "XP_011511753.1",
"transcript_support_level": null,
"aa_start": 479,
"aa_end": null,
"aa_length": 571,
"cds_start": 1436,
"cds_end": null,
"cds_length": 1716,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011513451.3"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1436T>A",
"hgvs_p": "p.Val479Glu",
"transcript": "XM_011513452.3",
"protein_id": "XP_011511754.1",
"transcript_support_level": null,
"aa_start": 479,
"aa_end": null,
"aa_length": 565,
"cds_start": 1436,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011513452.3"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1436T>A",
"hgvs_p": "p.Val479Glu",
"transcript": "XM_011513454.3",
"protein_id": "XP_011511756.1",
"transcript_support_level": null,
"aa_start": 479,
"aa_end": null,
"aa_length": 525,
"cds_start": 1436,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011513454.3"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1319T>A",
"hgvs_p": "p.Val440Glu",
"transcript": "XM_017008054.2",
"protein_id": "XP_016863543.1",
"transcript_support_level": null,
"aa_start": 440,
"aa_end": null,
"aa_length": 486,
"cds_start": 1319,
"cds_end": null,
"cds_length": 1461,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017008054.2"
},
{
"aa_ref": "V",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRK4",
"gene_hgnc_id": 4543,
"hgvs_c": "c.1223T>A",
"hgvs_p": "p.Val408Glu",
"transcript": "XM_017008055.2",
"protein_id": "XP_016863544.1",
"transcript_support_level": null,
"aa_start": 408,
"aa_end": null,
"aa_length": 454,
"cds_start": 1223,
"cds_end": null,
"cds_length": 1365,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
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}