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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 4-8428090-A-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=8428090&ref=A&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "4",
      "pos": 8428090,
      "ref": "A",
      "alt": "T",
      "effect": "intron_variant",
      "transcript": "NM_003501.3",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-14-11555T>A",
          "hgvs_p": null,
          "transcript": "NM_003501.3",
          "protein_id": "NP_003492.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 700,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2103,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000356406.10",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_003501.3"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-14-11555T>A",
          "hgvs_p": null,
          "transcript": "ENST00000356406.10",
          "protein_id": "ENSP00000348775.4",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 700,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2103,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_003501.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000356406.10"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-15+261T>A",
          "hgvs_p": null,
          "transcript": "ENST00000503233.5",
          "protein_id": "ENSP00000421625.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 700,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2103,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000503233.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-14-11555T>A",
          "hgvs_p": null,
          "transcript": "ENST00000413009.6",
          "protein_id": "ENSP00000413994.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 624,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1875,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000413009.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-458T>A",
          "hgvs_p": null,
          "transcript": "ENST00000952634.1",
          "protein_id": "ENSP00000622693.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 671,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2016,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000952634.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-15+261T>A",
          "hgvs_p": null,
          "transcript": "ENST00000895410.1",
          "protein_id": "ENSP00000565469.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 707,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2124,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000895410.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-15+261T>A",
          "hgvs_p": null,
          "transcript": "NM_001375783.1",
          "protein_id": "NP_001362712.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 700,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2103,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001375783.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-15+7833T>A",
          "hgvs_p": null,
          "transcript": "ENST00000895406.1",
          "protein_id": "ENSP00000565465.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 700,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2103,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000895406.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-15+217T>A",
          "hgvs_p": null,
          "transcript": "ENST00000895417.1",
          "protein_id": "ENSP00000565476.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 700,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2103,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000895417.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-291+261T>A",
          "hgvs_p": null,
          "transcript": "ENST00000923764.1",
          "protein_id": "ENSP00000593823.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 700,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2103,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923764.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 1,
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          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-15+261T>A",
          "hgvs_p": null,
          "transcript": "ENST00000952628.1",
          "protein_id": "ENSP00000622687.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 699,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2100,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000952628.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 18,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-15+261T>A",
          "hgvs_p": null,
          "transcript": "ENST00000895415.1",
          "protein_id": "ENSP00000565474.1",
          "transcript_support_level": null,
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          "cds_start": null,
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          "cds_length": 2091,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        {
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          "canonical": false,
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          "consequences": [
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          ],
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          "intron_rank": 1,
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          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-14-11555T>A",
          "hgvs_p": null,
          "transcript": "NM_001375784.1",
          "protein_id": "NP_001362713.1",
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          "cds_start": null,
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        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 18,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-15+261T>A",
          "hgvs_p": null,
          "transcript": "ENST00000952631.1",
          "protein_id": "ENSP00000622690.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 676,
          "cds_start": null,
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          "cdna_start": null,
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        {
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          "gene_symbol": "ACOX3",
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          "hgvs_c": "c.-14-11555T>A",
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        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
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          "intron_rank": 1,
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          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-15+261T>A",
          "hgvs_p": null,
          "transcript": "NM_001375786.1",
          "protein_id": "NP_001362715.1",
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          "biotype": "protein_coding",
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        {
          "aa_ref": null,
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          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-14-11555T>A",
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          "transcript": "ENST00000895405.1",
          "protein_id": "ENSP00000565464.1",
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        {
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          "gene_symbol": "ACOX3",
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          "hgvs_c": "c.-15+7833T>A",
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        {
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          "gene_symbol": "ACOX3",
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          "hgvs_c": "c.-15+261T>A",
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          "biotype": "protein_coding",
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        },
        {
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          "consequences": [
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          ],
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          "exon_count": 17,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ACOX3",
          "gene_hgnc_id": 121,
          "hgvs_c": "c.-15+217T>A",
          "hgvs_p": null,
          "transcript": "ENST00000923763.1",
          "protein_id": "ENSP00000593822.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "cds_length": 2016,
          "cdna_start": null,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923763.1"
        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 18,
          "intron_rank": 1,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.