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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-134128966-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=134128966&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 134128966,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000342854.10",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "TCF7",
"gene_hgnc_id": 11639,
"hgvs_c": "c.442-9093T>C",
"hgvs_p": null,
"transcript": "NM_003202.5",
"protein_id": "NP_003193.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 384,
"cds_start": -4,
"cds_end": null,
"cds_length": 1155,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3288,
"mane_select": "ENST00000342854.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "TCF7",
"gene_hgnc_id": 11639,
"hgvs_c": "c.442-9093T>C",
"hgvs_p": null,
"transcript": "ENST00000342854.10",
"protein_id": "ENSP00000340347.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 384,
"cds_start": -4,
"cds_end": null,
"cds_length": 1155,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3288,
"mane_select": "NM_003202.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TCF7",
"gene_hgnc_id": 11639,
"hgvs_c": "c.97-9093T>C",
"hgvs_p": null,
"transcript": "ENST00000395023.5",
"protein_id": "ENSP00000378469.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 269,
"cds_start": -4,
"cds_end": null,
"cds_length": 810,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2815,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TCF7",
"gene_hgnc_id": 11639,
"hgvs_c": "c.97-9093T>C",
"hgvs_p": null,
"transcript": "ENST00000518915.5",
"protein_id": "ENSP00000430179.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 269,
"cds_start": -4,
"cds_end": null,
"cds_length": 810,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1254,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TCF7",
"gene_hgnc_id": 11639,
"hgvs_c": "c.97-9093T>C",
"hgvs_p": null,
"transcript": "ENST00000378560.8",
"protein_id": "ENSP00000367822.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 268,
"cds_start": -4,
"cds_end": null,
"cds_length": 807,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2929,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "TCF7",
"gene_hgnc_id": 11639,
"hgvs_c": "c.442-9093T>C",
"hgvs_p": null,
"transcript": "ENST00000395029.5",
"protein_id": "ENSP00000378472.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 481,
"cds_start": -4,
"cds_end": null,
"cds_length": 1446,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3330,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "TCF7",
"gene_hgnc_id": 11639,
"hgvs_c": "c.442-9093T>C",
"hgvs_p": null,
"transcript": "NM_001346425.2",
"protein_id": "NP_001333354.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 415,
"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
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"cdna_length": 3381,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TCF7",
"gene_hgnc_id": 11639,
"hgvs_c": "c.97-9093T>C",
"hgvs_p": null,
"transcript": "ENST00000522375.6",
"protein_id": "ENSP00000427870.2",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 300,
"cds_start": -4,
"cds_end": null,
"cds_length": 903,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2840,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TCF7",
"gene_hgnc_id": 11639,
"hgvs_c": "c.97-9093T>C",
"hgvs_p": null,
"transcript": "NM_001346450.2",
"protein_id": "NP_001333379.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 281,
"cds_start": -4,
"cds_end": null,
"cds_length": 846,
"cdna_start": null,
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"cdna_length": 2924,
"mane_select": null,
"mane_plus": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 2,
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"gene_symbol": "TCF7",
"gene_hgnc_id": 11639,
"hgvs_c": "c.97-9093T>C",
"hgvs_p": null,
"transcript": "NM_001134851.4",
"protein_id": "NP_001128323.2",
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"cds_start": -4,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"gene_symbol": "TCF7",
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"hgvs_c": "c.97-9093T>C",
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"transcript": "NM_201632.5",
"protein_id": "NP_963963.1",
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},
{
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],
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],
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],
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],
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},
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],
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},
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],
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"gene_symbol": "TCF7",
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"hgvs_c": "c.21+5210T>C",
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"transcript": "ENST00000519037.5",
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},
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},
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],
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],
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"hgvs_c": "n.150-9093T>C",
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},
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"strand": true,
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],
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"intron_rank": 1,
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"gene_symbol": "TCF7",
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"hgvs_c": "n.79-9093T>C",
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"transcript": "ENST00000520652.5",
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},
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