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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-141656261-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=141656261&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 141656261,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_022481.6",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3805C>G",
"hgvs_p": "p.Arg1269Gly",
"transcript": "NM_022481.6",
"protein_id": "NP_071926.4",
"transcript_support_level": null,
"aa_start": 1269,
"aa_end": null,
"aa_length": 1544,
"cds_start": 3805,
"cds_end": null,
"cds_length": 4635,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000239440.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_022481.6"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3805C>G",
"hgvs_p": "p.Arg1269Gly",
"transcript": "ENST00000239440.9",
"protein_id": "ENSP00000239440.4",
"transcript_support_level": 1,
"aa_start": 1269,
"aa_end": null,
"aa_length": 1544,
"cds_start": 3805,
"cds_end": null,
"cds_length": 4635,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_022481.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000239440.9"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3805C>G",
"hgvs_p": "p.Arg1269Gly",
"transcript": "ENST00000955414.1",
"protein_id": "ENSP00000625473.1",
"transcript_support_level": null,
"aa_start": 1269,
"aa_end": null,
"aa_length": 1563,
"cds_start": 3805,
"cds_end": null,
"cds_length": 4692,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955414.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3745C>G",
"hgvs_p": "p.Arg1249Gly",
"transcript": "ENST00000925545.1",
"protein_id": "ENSP00000595604.1",
"transcript_support_level": null,
"aa_start": 1249,
"aa_end": null,
"aa_length": 1543,
"cds_start": 3745,
"cds_end": null,
"cds_length": 4632,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000925545.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3766C>G",
"hgvs_p": "p.Arg1256Gly",
"transcript": "ENST00000890876.1",
"protein_id": "ENSP00000560935.1",
"transcript_support_level": null,
"aa_start": 1256,
"aa_end": null,
"aa_length": 1531,
"cds_start": 3766,
"cds_end": null,
"cds_length": 4596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890876.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3763C>G",
"hgvs_p": "p.Arg1255Gly",
"transcript": "ENST00000925546.1",
"protein_id": "ENSP00000595605.1",
"transcript_support_level": null,
"aa_start": 1255,
"aa_end": null,
"aa_length": 1530,
"cds_start": 3763,
"cds_end": null,
"cds_length": 4593,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000925546.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3745C>G",
"hgvs_p": "p.Arg1249Gly",
"transcript": "ENST00000890874.1",
"protein_id": "ENSP00000560933.1",
"transcript_support_level": null,
"aa_start": 1249,
"aa_end": null,
"aa_length": 1524,
"cds_start": 3745,
"cds_end": null,
"cds_length": 4575,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890874.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3757C>G",
"hgvs_p": "p.Arg1253Gly",
"transcript": "ENST00000890873.1",
"protein_id": "ENSP00000560932.1",
"transcript_support_level": null,
"aa_start": 1253,
"aa_end": null,
"aa_length": 1515,
"cds_start": 3757,
"cds_end": null,
"cds_length": 4548,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890873.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3745C>G",
"hgvs_p": "p.Arg1249Gly",
"transcript": "ENST00000955415.1",
"protein_id": "ENSP00000625474.1",
"transcript_support_level": null,
"aa_start": 1249,
"aa_end": null,
"aa_length": 1511,
"cds_start": 3745,
"cds_end": null,
"cds_length": 4536,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955415.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3592C>G",
"hgvs_p": "p.Arg1198Gly",
"transcript": "ENST00000890875.1",
"protein_id": "ENSP00000560934.1",
"transcript_support_level": null,
"aa_start": 1198,
"aa_end": null,
"aa_length": 1473,
"cds_start": 3592,
"cds_end": null,
"cds_length": 4422,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890875.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3298C>G",
"hgvs_p": "p.Arg1100Gly",
"transcript": "ENST00000508305.5",
"protein_id": "ENSP00000421826.1",
"transcript_support_level": 2,
"aa_start": 1100,
"aa_end": null,
"aa_length": 1375,
"cds_start": 3298,
"cds_end": null,
"cds_length": 4128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000508305.5"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3298C>G",
"hgvs_p": "p.Arg1100Gly",
"transcript": "ENST00000626478.2",
"protein_id": "ENSP00000486980.1",
"transcript_support_level": 5,
"aa_start": 1100,
"aa_end": null,
"aa_length": 1375,
"cds_start": 3298,
"cds_end": null,
"cds_length": 4128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000626478.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.2791C>G",
"hgvs_p": "p.Arg931Gly",
"transcript": "ENST00000513878.5",
"protein_id": "ENSP00000421468.1",
"transcript_support_level": 2,
"aa_start": 931,
"aa_end": null,
"aa_length": 1193,
"cds_start": 2791,
"cds_end": null,
"cds_length": 3582,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000513878.5"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3805C>G",
"hgvs_p": "p.Arg1269Gly",
"transcript": "XM_047417505.1",
"protein_id": "XP_047273461.1",
"transcript_support_level": null,
"aa_start": 1269,
"aa_end": null,
"aa_length": 1544,
"cds_start": 3805,
"cds_end": null,
"cds_length": 4635,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417505.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3805C>G",
"hgvs_p": "p.Arg1269Gly",
"transcript": "XM_047417506.1",
"protein_id": "XP_047273462.1",
"transcript_support_level": null,
"aa_start": 1269,
"aa_end": null,
"aa_length": 1531,
"cds_start": 3805,
"cds_end": null,
"cds_length": 4596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417506.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3745C>G",
"hgvs_p": "p.Arg1249Gly",
"transcript": "XM_005268498.3",
"protein_id": "XP_005268555.1",
"transcript_support_level": null,
"aa_start": 1249,
"aa_end": null,
"aa_length": 1524,
"cds_start": 3745,
"cds_end": null,
"cds_length": 4575,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005268498.3"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3745C>G",
"hgvs_p": "p.Arg1249Gly",
"transcript": "XM_047417507.1",
"protein_id": "XP_047273463.1",
"transcript_support_level": null,
"aa_start": 1249,
"aa_end": null,
"aa_length": 1511,
"cds_start": 3745,
"cds_end": null,
"cds_length": 4536,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417507.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3592C>G",
"hgvs_p": "p.Arg1198Gly",
"transcript": "XM_047417508.1",
"protein_id": "XP_047273464.1",
"transcript_support_level": null,
"aa_start": 1198,
"aa_end": null,
"aa_length": 1473,
"cds_start": 3592,
"cds_end": null,
"cds_length": 4422,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417508.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3571C>G",
"hgvs_p": "p.Arg1191Gly",
"transcript": "XM_005268499.2",
"protein_id": "XP_005268556.1",
"transcript_support_level": null,
"aa_start": 1191,
"aa_end": null,
"aa_length": 1466,
"cds_start": 3571,
"cds_end": null,
"cds_length": 4401,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005268499.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3592C>G",
"hgvs_p": "p.Arg1198Gly",
"transcript": "XM_047417509.1",
"protein_id": "XP_047273465.1",
"transcript_support_level": null,
"aa_start": 1198,
"aa_end": null,
"aa_length": 1460,
"cds_start": 3592,
"cds_end": null,
"cds_length": 4383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417509.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3571C>G",
"hgvs_p": "p.Arg1191Gly",
"transcript": "XM_047417510.1",
"protein_id": "XP_047273466.1",
"transcript_support_level": null,
"aa_start": 1191,
"aa_end": null,
"aa_length": 1453,
"cds_start": 3571,
"cds_end": null,
"cds_length": 4362,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417510.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAP3",
"gene_hgnc_id": 24097,
"hgvs_c": "c.3511C>G",
"hgvs_p": "p.Arg1171Gly",
"transcript": "XM_047417511.1",
"protein_id": "XP_047273467.1",
"transcript_support_level": null,
"aa_start": 1171,
"aa_end": null,
"aa_length": 1446,
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"splice_prediction_selected": "Benign",
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{
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"BP4"
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"verdict": "Uncertain_significance",
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"inheritance_mode": "",
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"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"custom_annotations": null
}
],
"message": null
}