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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-143214082-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=143214082&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 143214082,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000645722.2",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2185G>T",
"hgvs_p": "p.Asp729Tyr",
"transcript": "NM_001135608.3",
"protein_id": "NP_001129080.1",
"transcript_support_level": null,
"aa_start": 729,
"aa_end": null,
"aa_length": 759,
"cds_start": 2185,
"cds_end": null,
"cds_length": 2280,
"cdna_start": 2570,
"cdna_end": null,
"cdna_length": 9226,
"mane_select": "ENST00000645722.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2185G>T",
"hgvs_p": "p.Asp729Tyr",
"transcript": "ENST00000645722.2",
"protein_id": "ENSP00000495131.1",
"transcript_support_level": null,
"aa_start": 729,
"aa_end": null,
"aa_length": 759,
"cds_start": 2185,
"cds_end": null,
"cds_length": 2280,
"cdna_start": 2570,
"cdna_end": null,
"cdna_length": 9226,
"mane_select": "NM_001135608.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2350G>T",
"hgvs_p": "p.Asp784Tyr",
"transcript": "ENST00000274498.9",
"protein_id": "ENSP00000274498.4",
"transcript_support_level": 1,
"aa_start": 784,
"aa_end": null,
"aa_length": 814,
"cds_start": 2350,
"cds_end": null,
"cds_length": 2445,
"cdna_start": 2735,
"cdna_end": null,
"cdna_length": 9395,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.787G>T",
"hgvs_p": "p.Asp263Tyr",
"transcript": "ENST00000418236.5",
"protein_id": "ENSP00000416889.1",
"transcript_support_level": 1,
"aa_start": 263,
"aa_end": null,
"aa_length": 293,
"cds_start": 787,
"cds_end": null,
"cds_length": 882,
"cdna_start": 789,
"cdna_end": null,
"cdna_length": 1632,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.193G>T",
"hgvs_p": "p.Asp65Tyr",
"transcript": "ENST00000425417.2",
"protein_id": "ENSP00000403388.2",
"transcript_support_level": 5,
"aa_start": 65,
"aa_end": null,
"aa_length": 96,
"cds_start": 193,
"cds_end": null,
"cds_length": 291,
"cdna_start": 195,
"cdna_end": null,
"cdna_length": 782,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2350G>T",
"hgvs_p": "p.Asp784Tyr",
"transcript": "NM_015071.6",
"protein_id": "NP_055886.1",
"transcript_support_level": null,
"aa_start": 784,
"aa_end": null,
"aa_length": 814,
"cds_start": 2350,
"cds_end": null,
"cds_length": 2445,
"cdna_start": 2735,
"cdna_end": null,
"cdna_length": 9395,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.1966G>T",
"hgvs_p": "p.Asp656Tyr",
"transcript": "NM_001349547.2",
"protein_id": "NP_001336476.1",
"transcript_support_level": null,
"aa_start": 656,
"aa_end": null,
"aa_length": 686,
"cds_start": 1966,
"cds_end": null,
"cds_length": 2061,
"cdna_start": 2069,
"cdna_end": null,
"cdna_length": 8729,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.1966G>T",
"hgvs_p": "p.Asp656Tyr",
"transcript": "ENST00000642734.1",
"protein_id": "ENSP00000495827.1",
"transcript_support_level": null,
"aa_start": 656,
"aa_end": null,
"aa_length": 686,
"cds_start": 1966,
"cds_end": null,
"cds_length": 2061,
"cdna_start": 2177,
"cdna_end": null,
"cdna_length": 3923,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.1069G>T",
"hgvs_p": "p.Asp357Tyr",
"transcript": "ENST00000443674.5",
"protein_id": "ENSP00000393276.1",
"transcript_support_level": 5,
"aa_start": 357,
"aa_end": null,
"aa_length": 387,
"cds_start": 1069,
"cds_end": null,
"cds_length": 1164,
"cdna_start": 1071,
"cdna_end": null,
"cdna_length": 2870,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.361G>T",
"hgvs_p": "p.Asp121Tyr",
"transcript": "ENST00000421521.5",
"protein_id": "ENSP00000389137.1",
"transcript_support_level": 5,
"aa_start": 121,
"aa_end": null,
"aa_length": 153,
"cds_start": 361,
"cds_end": null,
"cds_length": 462,
"cdna_start": 362,
"cdna_end": null,
"cdna_length": 783,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2350G>T",
"hgvs_p": "p.Asp784Tyr",
"transcript": "XM_047416970.1",
"protein_id": "XP_047272926.1",
"transcript_support_level": null,
"aa_start": 784,
"aa_end": null,
"aa_length": 816,
"cds_start": 2350,
"cds_end": null,
"cds_length": 2451,
"cdna_start": 2735,
"cdna_end": null,
"cdna_length": 3384,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2287G>T",
"hgvs_p": "p.Asp763Tyr",
"transcript": "XM_047416974.1",
"protein_id": "XP_047272930.1",
"transcript_support_level": null,
"aa_start": 763,
"aa_end": null,
"aa_length": 795,
"cds_start": 2287,
"cds_end": null,
"cds_length": 2388,
"cdna_start": 2575,
"cdna_end": null,
"cdna_length": 3224,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2287G>T",
"hgvs_p": "p.Asp763Tyr",
"transcript": "XM_047416975.1",
"protein_id": "XP_047272931.1",
"transcript_support_level": null,
"aa_start": 763,
"aa_end": null,
"aa_length": 793,
"cds_start": 2287,
"cds_end": null,
"cds_length": 2382,
"cdna_start": 2572,
"cdna_end": null,
"cdna_length": 9232,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2242G>T",
"hgvs_p": "p.Asp748Tyr",
"transcript": "XM_047416966.1",
"protein_id": "XP_047272922.1",
"transcript_support_level": null,
"aa_start": 748,
"aa_end": null,
"aa_length": 780,
"cds_start": 2242,
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"cdna_start": 2345,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2242G>T",
"hgvs_p": "p.Asp748Tyr",
"transcript": "XM_047416967.1",
"protein_id": "XP_047272923.1",
"transcript_support_level": null,
"aa_start": 748,
"aa_end": null,
"aa_length": 779,
"cds_start": 2242,
"cds_end": null,
"cds_length": 2340,
"cdna_start": 2345,
"cdna_end": null,
"cdna_length": 2990,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2239G>T",
"hgvs_p": "p.Asp747Tyr",
"transcript": "XM_047416977.1",
"protein_id": "XP_047272933.1",
"transcript_support_level": null,
"aa_start": 747,
"aa_end": null,
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"cds_start": 2239,
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"cdna_start": 5377,
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"cdna_length": 6025,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2242G>T",
"hgvs_p": "p.Asp748Tyr",
"transcript": "XM_005268398.6",
"protein_id": "XP_005268455.2",
"transcript_support_level": null,
"aa_start": 748,
"aa_end": null,
"aa_length": 778,
"cds_start": 2242,
"cds_end": null,
"cds_length": 2337,
"cdna_start": 2345,
"cdna_end": null,
"cdna_length": 9005,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2176G>T",
"hgvs_p": "p.Asp726Tyr",
"transcript": "XM_047416969.1",
"protein_id": "XP_047272925.1",
"transcript_support_level": null,
"aa_start": 726,
"aa_end": null,
"aa_length": 758,
"cds_start": 2176,
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"cds_length": 2277,
"cdna_start": 2279,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2152G>T",
"hgvs_p": "p.Asp718Tyr",
"transcript": "XM_047416980.1",
"protein_id": "XP_047272936.1",
"transcript_support_level": null,
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"aa_end": null,
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"cds_start": 2152,
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"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2122G>T",
"hgvs_p": "p.Asp708Tyr",
"transcript": "XM_047416982.1",
"protein_id": "XP_047272938.1",
"transcript_support_level": null,
"aa_start": 708,
"aa_end": null,
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"cds_start": 2122,
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"cdna_start": 2402,
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"mane_select": null,
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"feature": null
},
{
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"aa_alt": "Y",
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2110G>T",
"hgvs_p": "p.Asp704Tyr",
"transcript": "XM_047416983.1",
"protein_id": "XP_047272939.1",
"transcript_support_level": null,
"aa_start": 704,
"aa_end": null,
"aa_length": 736,
"cds_start": 2110,
"cds_end": null,
"cds_length": 2211,
"cdna_start": 3316,
"cdna_end": null,
"cdna_length": 3964,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP26",
"gene_hgnc_id": 17073,
"hgvs_c": "c.2110G>T",
"hgvs_p": "p.Asp704Tyr",
"transcript": "XM_047416984.1",
"protein_id": "XP_047272940.1",
"transcript_support_level": null,
"aa_start": 704,
"aa_end": null,
"aa_length": 736,
"cds_start": 2110,
"cds_end": null,
"cds_length": 2211,
"cdna_start": 12059,
"cdna_end": null,
"cdna_length": 12707,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 24,
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