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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-143320934-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=143320934&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 143320934,
"ref": "C",
"alt": "G",
"effect": "intron_variant",
"transcript": "NM_000176.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NR3C1",
"gene_hgnc_id": 7978,
"hgvs_c": "c.1185-6766G>C",
"hgvs_p": null,
"transcript": "NM_000176.3",
"protein_id": "NP_000167.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 777,
"cds_start": -4,
"cds_end": null,
"cds_length": 2334,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6778,
"mane_select": "ENST00000394464.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NR3C1",
"gene_hgnc_id": 7978,
"hgvs_c": "c.1185-6766G>C",
"hgvs_p": null,
"transcript": "ENST00000394464.7",
"protein_id": "ENSP00000377977.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 777,
"cds_start": -4,
"cds_end": null,
"cds_length": 2334,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6778,
"mane_select": "NM_000176.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NR3C1",
"gene_hgnc_id": 7978,
"hgvs_c": "c.1185-6766G>C",
"hgvs_p": null,
"transcript": "ENST00000231509.7",
"protein_id": "ENSP00000231509.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 778,
"cds_start": -4,
"cds_end": null,
"cds_length": 2337,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3556,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NR3C1",
"gene_hgnc_id": 7978,
"hgvs_c": "c.1185-6766G>C",
"hgvs_p": null,
"transcript": "ENST00000504572.5",
"protein_id": "ENSP00000422518.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 778,
"cds_start": -4,
"cds_end": null,
"cds_length": 2337,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3389,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NR3C1",
"gene_hgnc_id": 7978,
"hgvs_c": "c.1185-6766G>C",
"hgvs_p": null,
"transcript": "ENST00000503201.1",
"protein_id": "ENSP00000427672.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 777,
"cds_start": -4,
"cds_end": null,
"cds_length": 2334,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2594,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NR3C1",
"gene_hgnc_id": 7978,
"hgvs_c": "c.1107-6766G>C",
"hgvs_p": null,
"transcript": "ENST00000424646.6",
"protein_id": "ENSP00000405282.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 751,
"cds_start": -4,
"cds_end": null,
"cds_length": 2256,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4591,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NR3C1",
"gene_hgnc_id": 7978,
"hgvs_c": "c.1185-6766G>C",
"hgvs_p": null,
"transcript": "ENST00000415690.6",
"protein_id": "ENSP00000387672.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 742,
"cds_start": -4,
"cds_end": null,
"cds_length": 2229,
"cdna_start": null,
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"cdna_length": 3789,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": null,
"protein_coding": null,
"strand": true,
"consequences": [
"intragenic_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": null,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RPL7P21",
"gene_hgnc_id": 36762,
"hgvs_c": "n.143320934C>G",
"hgvs_p": null,
"transcript": null,
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NR3C1",
"gene_hgnc_id": 7978,
"hgvs_c": "c.1185-6766G>C",
"hgvs_p": null,
"transcript": "NM_001024094.2",
"protein_id": "NP_001019265.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 778,
"cds_start": -4,
"cds_end": null,
"cds_length": 2337,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6781,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NR3C1",
"gene_hgnc_id": 7978,
"hgvs_c": "c.1185-6766G>C",
"hgvs_p": null,
"transcript": "NM_001364183.2",
"protein_id": "NP_001351112.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 2,
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"gene_symbol": "NR3C1",
"gene_hgnc_id": 7978,
"hgvs_c": "c.1185-6766G>C",
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"transcript": "NM_001364184.2",
"protein_id": "NP_001351113.1",
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},
{
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],
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"gene_symbol": "NR3C1",
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},
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],
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"gene_symbol": "NR3C1",
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"hgvs_c": "c.1185-6766G>C",
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"transcript": "ENST00000394466.6",
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},
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],
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"gene_symbol": "NR3C1",
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],
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},
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],
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"gene_symbol": "NR3C1",
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"hgvs_c": "c.1185-6766G>C",
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},
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],
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"gene_symbol": "NR3C1",
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"hgvs_c": "c.1185-6766G>C",
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},
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],
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],
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"gene_symbol": "NR3C1",
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"hgvs_c": "c.1107-6766G>C",
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"transcript": "NM_001204258.2",
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},
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"consequences": [
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],
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"intron_rank": 1,
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"gene_symbol": "NR3C1",
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"hgvs_c": "c.1185-6766G>C",
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"transcript": "ENST00000652686.1",
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}
],
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}