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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 5-150126578-A-AATC (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=150126578&ref=A&alt=AATC&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "5",
      "pos": 150126578,
      "ref": "A",
      "alt": "AATC",
      "effect": "conservative_inframe_insertion",
      "transcript": "NM_002609.4",
      "consequences": [
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "NM_002609.4",
          "protein_id": "NP_002600.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1106,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3321,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000261799.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_002609.4"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000261799.9",
          "protein_id": "ENSP00000261799.4",
          "transcript_support_level": 1,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1106,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3321,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_002609.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000261799.9"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "n.*929_*930insGAT",
          "hgvs_p": null,
          "transcript": "ENST00000520579.5",
          "protein_id": "ENSP00000430026.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000520579.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "n.*929_*930insGAT",
          "hgvs_p": null,
          "transcript": "ENST00000520579.5",
          "protein_id": "ENSP00000430026.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000520579.5"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000890716.1",
          "protein_id": "ENSP00000560775.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1140,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3423,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000890716.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1696_1697insGAT",
          "hgvs_p": "p.Ile565_Leu566insArg",
          "transcript": "ENST00000890721.1",
          "protein_id": "ENSP00000560780.1",
          "transcript_support_level": null,
          "aa_start": 566,
          "aa_end": null,
          "aa_length": 1133,
          "cds_start": 1696,
          "cds_end": null,
          "cds_length": 3402,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000890721.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1672_1673insGAT",
          "hgvs_p": "p.Ile557_Leu558insArg",
          "transcript": "ENST00000890727.1",
          "protein_id": "ENSP00000560786.1",
          "transcript_support_level": null,
          "aa_start": 558,
          "aa_end": null,
          "aa_length": 1125,
          "cds_start": 1672,
          "cds_end": null,
          "cds_length": 3378,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000890727.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000890715.1",
          "protein_id": "ENSP00000560774.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1106,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3321,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000890715.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000890717.1",
          "protein_id": "ENSP00000560776.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1106,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3321,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000890717.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000890718.1",
          "protein_id": "ENSP00000560777.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1106,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3321,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000890718.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000890723.1",
          "protein_id": "ENSP00000560782.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1106,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3321,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000890723.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000890724.1",
          "protein_id": "ENSP00000560783.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1106,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3321,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000890724.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000890725.1",
          "protein_id": "ENSP00000560784.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1106,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3321,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000890725.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000890726.1",
          "protein_id": "ENSP00000560785.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1106,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3321,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000890726.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000951660.1",
          "protein_id": "ENSP00000621719.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1106,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3321,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000951660.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000951664.1",
          "protein_id": "ENSP00000621723.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1106,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3321,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000951664.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000890720.1",
          "protein_id": "ENSP00000560779.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1105,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3318,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000890720.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000951663.1",
          "protein_id": "ENSP00000621722.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1105,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3318,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000951663.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg",
          "transcript": "ENST00000951661.1",
          "protein_id": "ENSP00000621720.1",
          "transcript_support_level": null,
          "aa_start": 539,
          "aa_end": null,
          "aa_length": 1100,
          "cds_start": 1615,
          "cds_end": null,
          "cds_length": 3303,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000951661.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
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          "gene_hgnc_id": 8804,
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          "hgvs_p": "p.Ile508_Leu509insArg",
          "transcript": "ENST00000951662.1",
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          "cds_start": 1525,
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          "cds_length": 3231,
          "cdna_start": null,
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          "mane_select": null,
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          "feature": "ENST00000951662.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
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          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1456_1457insGAT",
          "hgvs_p": "p.Ile485_Leu486insArg",
          "transcript": "ENST00000890719.1",
          "protein_id": "ENSP00000560778.1",
          "transcript_support_level": null,
          "aa_start": 486,
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          "aa_length": 1053,
          "cds_start": 1456,
          "cds_end": null,
          "cds_length": 3162,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000890719.1"
        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
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          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
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          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1423_1424insGAT",
          "hgvs_p": "p.Ile474_Leu475insArg",
          "transcript": "NM_001355016.2",
          "protein_id": "NP_001341945.1",
          "transcript_support_level": null,
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          "cds_start": 1423,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001355016.2"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
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          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1306_1307insGAT",
          "hgvs_p": "p.Ile435_Leu436insArg",
          "transcript": "ENST00000890722.1",
          "protein_id": "ENSP00000560781.1",
          "transcript_support_level": null,
          "aa_start": 436,
          "aa_end": null,
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          "cds_start": 1306,
          "cds_end": null,
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          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000890722.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "RL",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "conservative_inframe_insertion"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDGFRB",
          "gene_hgnc_id": 8804,
          "hgvs_c": "c.1132_1133insGAT",
          "hgvs_p": "p.Ile377_Leu378insArg",
          "transcript": "NM_001355017.2",
          "protein_id": "NP_001341946.1",
          "transcript_support_level": null,
          "aa_start": 378,
          "aa_end": null,
          "aa_length": 945,
          "cds_start": 1132,
          "cds_end": null,
          "cds_length": 2838,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001355017.2"
        }
      ],
      "gene_symbol": "PDGFRB",
      "gene_hgnc_id": 8804,
      "dbsnp": "rs1060499541",
      "frequency_reference_population": null,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 0,
      "gnomad_exomes_af": null,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": null,
      "computational_prediction_selected": null,
      "computational_source_selected": null,
      "splice_score_selected": null,
      "splice_prediction_selected": null,
      "splice_source_selected": null,
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": null,
      "bayesdelnoaf_prediction": null,
      "phylop100way_score": 2.998,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": null,
      "spliceai_max_prediction": null,
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 4,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,PM4_Supporting,PP5",
      "acmg_by_gene": [
        {
          "score": 4,
          "benign_score": 0,
          "pathogenic_score": 4,
          "criteria": [
            "PM2",
            "PM4_Supporting",
            "PP5"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_002609.4",
          "gene_symbol": "PDGFRB",
          "hgnc_id": 8804,
          "effects": [
            "conservative_inframe_insertion"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.1615_1616insGAT",
          "hgvs_p": "p.Ile538_Leu539insArg"
        }
      ],
      "clinvar_disease": "Infantile myofibromatosis",
      "clinvar_classification": "Pathogenic",
      "clinvar_review_status": "no assertion criteria provided",
      "clinvar_submissions_summary": "null",
      "phenotype_combined": "Infantile myofibromatosis",
      "pathogenicity_classification_combined": "Pathogenic",
      "custom_annotations": null
    }
  ],
  "message": null
}