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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-36157713-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=36157713&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 36157713,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000274255.11",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SKP2",
"gene_hgnc_id": 10901,
"hgvs_c": "c.280+4671T>C",
"hgvs_p": null,
"transcript": "NM_005983.4",
"protein_id": "NP_005974.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 424,
"cds_start": -4,
"cds_end": null,
"cds_length": 1275,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3715,
"mane_select": "ENST00000274255.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SKP2",
"gene_hgnc_id": 10901,
"hgvs_c": "c.280+4671T>C",
"hgvs_p": null,
"transcript": "ENST00000274255.11",
"protein_id": "ENSP00000274255.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 424,
"cds_start": -4,
"cds_end": null,
"cds_length": 1275,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3715,
"mane_select": "NM_005983.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SKP2",
"gene_hgnc_id": 10901,
"hgvs_c": "c.280+4671T>C",
"hgvs_p": null,
"transcript": "ENST00000274254.9",
"protein_id": "ENSP00000274254.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 410,
"cds_start": -4,
"cds_end": null,
"cds_length": 1233,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1537,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SKP2",
"gene_hgnc_id": 10901,
"hgvs_c": "c.281-2060T>C",
"hgvs_p": null,
"transcript": "ENST00000546211.6",
"protein_id": "ENSP00000443492.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 458,
"cds_start": -4,
"cds_end": null,
"cds_length": 1377,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3522,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SKP2",
"gene_hgnc_id": 10901,
"hgvs_c": "c.280+4671T>C",
"hgvs_p": null,
"transcript": "NM_032637.4",
"protein_id": "NP_116026.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 410,
"cds_start": -4,
"cds_end": null,
"cds_length": 1233,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1403,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SKP2",
"gene_hgnc_id": 10901,
"hgvs_c": "c.280+4671T>C",
"hgvs_p": null,
"transcript": "ENST00000620197.5",
"protein_id": "ENSP00000478031.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 379,
"cds_start": -4,
"cds_end": null,
"cds_length": 1140,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3299,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SKP2",
"gene_hgnc_id": 10901,
"hgvs_c": "c.280+4671T>C",
"hgvs_p": null,
"transcript": "ENST00000678270.1",
"protein_id": "ENSP00000502955.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 374,
"cds_start": -4,
"cds_end": null,
"cds_length": 1125,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2854,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SKP2",
"gene_hgnc_id": 10901,
"hgvs_c": "c.280+4671T>C",
"hgvs_p": null,
"transcript": "ENST00000678580.1",
"protein_id": "ENSP00000504064.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 358,
"cds_start": -4,
"cds_end": null,
"cds_length": 1077,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6576,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SKP2",
"gene_hgnc_id": 10901,
"hgvs_c": "c.280+4671T>C",
"hgvs_p": null,
"transcript": "ENST00000508514.5",
"protein_id": "ENSP00000421941.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 217,
"cds_start": -4,
"cds_end": null,
"cds_length": 654,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 821,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SKP2",
"gene_hgnc_id": 10901,
"hgvs_c": "c.-116+4671T>C",
"hgvs_p": null,
"transcript": "NM_001243120.2",
"protein_id": "NP_001230049.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 210,
"cds_start": -4,
"cds_end": null,
"cds_length": 633,
"cdna_start": null,
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"cdna_length": 3468,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SKP2",
"gene_hgnc_id": 10901,
"hgvs_c": "c.-63+5443T>C",
"hgvs_p": null,
"transcript": "ENST00000679015.1",
"protein_id": "ENSP00000503700.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 103,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
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"gene_symbol": "SKP2",
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"hgvs_c": "n.112+4671T>C",
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"transcript": "ENST00000504386.1",
"protein_id": "ENSP00000424234.1",
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"feature": null
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
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"exon_count": 8,
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"gene_symbol": "SKP2",
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"hgvs_c": "n.280+4671T>C",
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"transcript": "ENST00000509692.5",
"protein_id": "ENSP00000426004.1",
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},
{
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"strand": true,
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],
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"gene_symbol": "SKP2",
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"hgvs_c": "n.280+4671T>C",
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"transcript": "ENST00000513151.6",
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},
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],
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 2,
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"gene_symbol": "SKP2",
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"hgvs_c": "n.280+4671T>C",
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"transcript": "ENST00000676559.1",
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},
{
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],
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"gene_symbol": "SKP2",
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"transcript": "ENST00000677537.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
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"gene_symbol": "SKP2",
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"hgvs_c": "n.235+4671T>C",
"hgvs_p": null,
"transcript": "ENST00000677861.1",
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},
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],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 2,
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"gene_symbol": "SKP2",
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"hgvs_c": "n.280+4671T>C",
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},
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],
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},
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],
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},
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"consequences": [
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],
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"gene_symbol": "SKP2",
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"hgvs_c": "n.280+4671T>C",
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"transcript": "ENST00000678260.1",
"protein_id": "ENSP00000503527.1",
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"biotype": null,
"feature": null
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SKP2",
"gene_hgnc_id": 10901,
"hgvs_c": "n.280+4671T>C",
"hgvs_p": null,
"transcript": "ENST00000678537.1",
"protein_id": "ENSP00000503698.1",
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},
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}
],
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}