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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-50730631-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=50730631&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 50730631,
"ref": "C",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000281631.10",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "c.147-19520C>G",
"hgvs_p": null,
"transcript": "NM_024615.4",
"protein_id": "NP_078891.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 854,
"cds_start": -4,
"cds_end": null,
"cds_length": 2565,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7475,
"mane_select": "ENST00000281631.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "c.147-19520C>G",
"hgvs_p": null,
"transcript": "ENST00000281631.10",
"protein_id": "ENSP00000281631.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 854,
"cds_start": -4,
"cds_end": null,
"cds_length": 2565,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7475,
"mane_select": "NM_024615.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "c.147-19520C>G",
"hgvs_p": null,
"transcript": "ENST00000505697.6",
"protein_id": "ENSP00000422217.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 854,
"cds_start": -4,
"cds_end": null,
"cds_length": 2565,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2747,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "c.147-19520C>G",
"hgvs_p": null,
"transcript": "ENST00000514067.6",
"protein_id": "ENSP00000424814.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 812,
"cds_start": -4,
"cds_end": null,
"cds_length": 2439,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2829,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "n.234-19520C>G",
"hgvs_p": null,
"transcript": "ENST00000503561.7",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2818,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "c.270-19520C>G",
"hgvs_p": null,
"transcript": "NM_001427055.1",
"protein_id": "NP_001413984.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 895,
"cds_start": -4,
"cds_end": null,
"cds_length": 2688,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7388,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "c.147-19520C>G",
"hgvs_p": null,
"transcript": "NM_001178055.2",
"protein_id": "NP_001171526.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 854,
"cds_start": -4,
"cds_end": null,
"cds_length": 2565,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7166,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "c.84-19520C>G",
"hgvs_p": null,
"transcript": "NM_001331028.2",
"protein_id": "NP_001317957.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 833,
"cds_start": -4,
"cds_end": null,
"cds_length": 2502,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7113,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "c.84-19520C>G",
"hgvs_p": null,
"transcript": "ENST00000505554.5",
"protein_id": "ENSP00000423946.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 833,
"cds_start": -4,
"cds_end": null,
"cds_length": 2502,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3825,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "c.147-19520C>G",
"hgvs_p": null,
"transcript": "NM_001178056.2",
"protein_id": "NP_001171527.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 812,
"cds_start": -4,
"cds_end": null,
"cds_length": 2439,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7349,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "c.147-8349C>G",
"hgvs_p": null,
"transcript": "ENST00000513738.5",
"protein_id": "ENSP00000422355.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 133,
"cds_start": -4,
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"cds_length": 402,
"cdna_start": null,
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"cdna_length": 596,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
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"intron_rank_end": null,
"gene_symbol": "PARP8",
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"hgvs_c": "c.147-19520C>G",
"hgvs_p": null,
"transcript": "ENST00000503046.5",
"protein_id": "ENSP00000421708.1",
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"aa_start": null,
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"cds_start": -4,
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"cds_length": 349,
"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 3,
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"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "c.270-47438C>G",
"hgvs_p": null,
"transcript": "ENST00000515175.6",
"protein_id": "ENSP00000423133.2",
"transcript_support_level": 3,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 3,
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"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "c.147-19520C>G",
"hgvs_p": null,
"transcript": "ENST00000502524.5",
"protein_id": "ENSP00000426243.1",
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},
{
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],
"exon_rank": null,
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"gene_symbol": "PARP8",
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"hgvs_c": "c.147-14105C>G",
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"transcript": "ENST00000503665.5",
"protein_id": "ENSP00000427138.1",
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "n.92-19520C>G",
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"transcript": "ENST00000503193.5",
"protein_id": "ENSP00000424916.1",
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},
{
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],
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"gene_symbol": "PARP8",
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"hgvs_c": "n.147-19520C>G",
"hgvs_p": null,
"transcript": "ENST00000503707.6",
"protein_id": "ENSP00000426679.2",
"transcript_support_level": 4,
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"feature": null
},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "n.329-19520C>G",
"hgvs_p": null,
"transcript": "ENST00000503790.6",
"protein_id": null,
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"aa_start": null,
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},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PARP8",
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"hgvs_c": "n.92-19520C>G",
"hgvs_p": null,
"transcript": "ENST00000503888.5",
"protein_id": "ENSP00000421503.1",
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},
{
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"strand": true,
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],
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"intron_rank": 1,
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},
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],
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"gene_symbol": "PARP8",
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"hgvs_c": "n.147-29012C>G",
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
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"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "n.147-19520C>G",
"hgvs_p": null,
"transcript": "ENST00000510303.6",
"protein_id": "ENSP00000422288.2",
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"aa_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PARP8",
"gene_hgnc_id": 26124,
"hgvs_c": "n.329-19520C>G",
"hgvs_p": null,
"transcript": "ENST00000511363.6",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"mane_select": null,
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},
{
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}