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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-76620080-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=76620080&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 76620080,
"ref": "C",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000274364.11",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "IQGAP2",
"gene_hgnc_id": 6111,
"hgvs_c": "c.1522-7330C>A",
"hgvs_p": null,
"transcript": "NM_006633.5",
"protein_id": "NP_006624.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1575,
"cds_start": -4,
"cds_end": null,
"cds_length": 4728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5808,
"mane_select": "ENST00000274364.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "IQGAP2",
"gene_hgnc_id": 6111,
"hgvs_c": "c.1522-7330C>A",
"hgvs_p": null,
"transcript": "ENST00000274364.11",
"protein_id": "ENSP00000274364.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1575,
"cds_start": -4,
"cds_end": null,
"cds_length": 4728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5808,
"mane_select": "NM_006633.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "F2RL2",
"gene_hgnc_id": 3539,
"hgvs_c": "c.65-1438G>T",
"hgvs_p": null,
"transcript": "NM_004101.4",
"protein_id": "NP_004092.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 374,
"cds_start": -4,
"cds_end": null,
"cds_length": 1125,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3398,
"mane_select": "ENST00000296641.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "F2RL2",
"gene_hgnc_id": 3539,
"hgvs_c": "c.65-1438G>T",
"hgvs_p": null,
"transcript": "ENST00000296641.5",
"protein_id": "ENSP00000296641.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 374,
"cds_start": -4,
"cds_end": null,
"cds_length": 1125,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3398,
"mane_select": "NM_004101.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "IQGAP2",
"gene_hgnc_id": 6111,
"hgvs_c": "c.181-7330C>A",
"hgvs_p": null,
"transcript": "ENST00000396234.7",
"protein_id": "ENSP00000379535.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1071,
"cds_start": -4,
"cds_end": null,
"cds_length": 3216,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3376,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "IQGAP2",
"gene_hgnc_id": 6111,
"hgvs_c": "c.1441-7330C>A",
"hgvs_p": null,
"transcript": "ENST00000514350.5",
"protein_id": "ENSP00000423672.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 823,
"cds_start": -4,
"cds_end": null,
"cds_length": 2474,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2617,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "IQGAP2",
"gene_hgnc_id": 6111,
"hgvs_c": "c.1372-7330C>A",
"hgvs_p": null,
"transcript": "NM_001285460.2",
"protein_id": "NP_001272389.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1525,
"cds_start": -4,
"cds_end": null,
"cds_length": 4578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5444,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "IQGAP2",
"gene_hgnc_id": 6111,
"hgvs_c": "c.1372-7330C>A",
"hgvs_p": null,
"transcript": "ENST00000379730.7",
"protein_id": "ENSP00000442313.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1525,
"cds_start": -4,
"cds_end": null,
"cds_length": 4578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5442,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "IQGAP2",
"gene_hgnc_id": 6111,
"hgvs_c": "c.181-7330C>A",
"hgvs_p": null,
"transcript": "NM_001285461.2",
"protein_id": "NP_001272390.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1071,
"cds_start": -4,
"cds_end": null,
"cds_length": 3216,
"cdna_start": null,
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"cdna_length": 4088,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "IQGAP2",
"gene_hgnc_id": 6111,
"hgvs_c": "c.181-7330C>A",
"hgvs_p": null,
"transcript": "NM_001285462.2",
"protein_id": "NP_001272391.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1071,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 4139,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "IQGAP2",
"gene_hgnc_id": 6111,
"hgvs_c": "c.181-7330C>A",
"hgvs_p": null,
"transcript": "ENST00000502745.5",
"protein_id": "ENSP00000426027.1",
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"aa_start": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
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"exon_count": 13,
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"gene_symbol": "IQGAP2",
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"hgvs_c": "c.181-7330C>A",
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"transcript": "ENST00000514001.5",
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},
{
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"canonical": false,
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"strand": false,
"consequences": [
"intron_variant"
],
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"exon_count": 2,
"intron_rank": 1,
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"gene_symbol": "F2RL2",
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"hgvs_c": "c.-2-1438G>T",
"hgvs_p": null,
"transcript": "NM_001256566.2",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"exon_count": 2,
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"gene_symbol": "F2RL2",
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"hgvs_c": "c.-2-1438G>T",
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"transcript": "ENST00000504899.1",
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},
{
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],
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"gene_symbol": "IQGAP2",
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"transcript": "ENST00000685564.1",
"protein_id": "ENSP00000510681.1",
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},
{
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"strand": true,
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],
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"gene_symbol": "IQGAP2",
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"hgvs_c": "c.181-7330C>A",
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"transcript": "ENST00000509074.5",
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},
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],
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"gene_symbol": "IQGAP2",
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"transcript": "ENST00000504254.5",
"protein_id": "ENSP00000423258.1",
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},
{
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],
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"intron_rank": 2,
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"gene_symbol": "IQGAP2",
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"hgvs_c": "n.258-7330C>A",
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"transcript": "ENST00000513534.1",
"protein_id": null,
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},
{
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "IQGAP2",
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"hgvs_c": "n.94-7330C>A",
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},
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],
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},
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],
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"gene_symbol": "IQGAP2",
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},
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "IQGAP2",
"gene_hgnc_id": 6111,
"hgvs_c": "c.1516-7330C>A",
"hgvs_p": null,
"transcript": "XM_024454336.2",
"protein_id": "XP_024310104.1",
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "IQGAP2",
"gene_hgnc_id": 6111,
"hgvs_c": "c.1441-7330C>A",
"hgvs_p": null,
"transcript": "XM_005248410.4",
"protein_id": "XP_005248467.1",
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{
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}
],
"message": null
}